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HLA-DR/DQ molecular mismatch: A prognostic biomarker for primary alloimmunity*

from American Journal of Transplantation

Alloimmune risk stratification in renal transplantation has lacked the necessary prognostic biomarkers to personalize recipient care or optimize clinical trials. HLA molecular mismatch improves precision compared to traditional antigen mismatch but has not been studied in detail at the individual molecule level. This study evaluated 664 renal transplant recipients and correlated HLA‐DR/DQ single molecule eplet mismatch with serologic, histologic, and clinical outcomes.

*As recommended by the Science & Technology Initiatives Committee
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