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Very early introduction of everolimus in de novo liver transplantation: Results of a multicenter, prospective, randomized trial

from Liver Transplantation

Early everolimus introduction and tacrolimus minimization after liver transplantation may represent a novel immunosuppressant approach. This phase 2, multicenter, randomized, open-label trial evaluated safety and efficacy of early everolimus initiation. Patients treated with corticosteroids, tacrolimus, and basiliximab, were randomized to receive everolimus in day eight and gradually minimize or withdraw tacrolimus when everolimus was stable greater than 5 ng/mL, or to continue tacrolimus at 6-12 ng/mL. more

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