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Effect of 3-mercaptopyruvate sulfurtransferase deficiency on the development of multiorgan failure, inflammation and wound healing in mice subjected to burn injury

from Journal of Burn Care & Research

The gaseous transmitter hydrogen sulfide (H2S) has been implicated in various forms of critical illness. Here we have compared the outcome of scald burn injury in wild-type mice and in mice deficient in 3-mercaptopyruvate sulfurtransferase (3-MST), a mammalian H2S-generating enzyme. Outcome variables included indices of organ injury, clinical chemistry parameters and plasma levels of inflammatory mediators. more


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