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Scientists developed a new mouse model of Hirschsprung's disease

from Drug Target Review

About one in every 5,000 babies is born without enteric neurons in distal colon resulting in Hirschsprung’s disease. Because of the lacking neurons, contents of the gut cannot pass normally resulting in constipation and enlargement of the colon. The condition is treated with surgical removal of the affected gut part, but the patients remain at high risk of enterocolitis, or inflammation of the gut. This is the major life-threatening complication of Hirschsprung’s disease. more

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