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Local thermal ablation with continuous epidermal growth factor receptor tyrosine kinase inhibitors for EGFR-mutant nonsmall cell lung cancers that developed extra-central nervous system oligoprogressive disease

from Cardiovascular and Interventional Radiology

Most epidermal growth factor receptor (EGFR)-mutant nonsmall cell lung cancer (NSCLC) patients treated with tyrosine kinase inhibitors (TKIs) experience oligoprogressive disease. Local ablation for isolated resistant sites continued with the original EGFR-TKI showed good efficacy in these patients. This multicenter retrospective study was conducted to investigate the potential benefit of thermal ablation in NSCLC patients that developed extra-central nervous system (CNS) oligoprogressive disease during TKI treatment. more


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