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Influence of ERAP1 and ERAP2 gene polymorphisms on disease susceptibility in different populations

from Human Immunology

The endoplasmic reticulum aminopeptidases (ERAPs), ERAP1 and ERAP2, makes a role in shaping the HLA class I peptidome by trimming peptides to the optimal size in MHC-class I-mediated antigen presentation and educating the immune system to differentiate between self-derived and foreign antigens. more

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