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Review: Using modified mesenchymal stem cells to promote healing in diabetic wounds

from Wound Source

The therapeutic potential of stem cells in chronic, nonhealing diabetic wounds comes from their ability to secrete cytokines, which play a role in healing. A study with critical limb ischemia patients was done in the past where it was reported that using autologous mesenchymal stem cells (MSCs) could lower limb amputation rates. MSCs have been genetically modified with stromal cell-derived factor 1 (SDF-1) and vascular endothelial growth factor in the past to improve wound healing. This study evaluates the healing potential of chronic diabetic wounds with transfection of interleukin 7 (IL-7) into rat bone marrow MSCs. more

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