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Nitric oxide and hepatocellular cancer

from British Journal of Pharmacology

Nitric oxide (NO) has broad and sometimes dichotomous roles in cancer. The effects of NO in tumors depend on the type and localization of NOS isoforms, concentration and duration of NO exposure, and cellular sensitivity to NO. Hepatocellular cancer (HCC) is a common and lethal disease for which no effective therapy other than surgical resection exists. Over two decades of research has yielded evidence that NO generated by the inducible NO synthase (iNOS or NOS2) contributes to HCC progression in at least a subset of patients with HCC. The co‐expression of iNOS with cyclooxygenase‐2 (COX‐2) may portend a particularly aggressive cancer phenotype in HCC and at the same time reveal an opportunity for pharmacologic intervention. more

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