APHON Week in Review MultiBriefs
May 17, 2012
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More chemotherapy might be best move for some children with leukemia
Oncology Nurse Advisor
Following failure of induction therapy, some children with acute lymphoblastic leukemia appear to have a better outcome with additional chemotherapy than with allogeneic stem cell transplantation, a large, long-term study has revealed. Investigators evaluated the outcomes of 44,017 patients with ALL aged 17 years and younger who had been diagnosed during a 15-year period ending in December 2000. Each child had undergone treatment through a clinical trial at one of the centers participating in this international collaborative analysis. Induction failure was defined by the persistence of leukemic blasts in blood, bone marrow, or any extramedullary site after 4 to 6 weeks of remission-induction therapy. More

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