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ASCLS eNewsBytes
July 21, 2009
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Putting Digital Pathology Under the Microscope
from Clinical Lab Products
For pathologists, the wow factor of digitizing images has not been enough to push its widespread adoption. Having been "raised" looking through a microscope, busy pathologists have not wanted to take the time and expense to acquire and learn to use a new system that didn't offer many perceived advantages over the old one. But technology marches on, and the challenges inherent to storing, streaming, sharing, and analyzing considerably large digital image files have begun to be conquered. As digital pathology systems become more functional, they add value beyond what the microscope can offer and become must-haves for pathology laboratories. More    E-mail article


Beckman Coulter

Endothelial Cells in Blood May Help Spread Childhood Cancer
from HealthDay News via Modern Medicine
Endothelial cells and progenitor cells circulating in the blood of pediatric cancer patients may play a role in the inception and progression of metastatic disease, according to a study in Clinical Cancer Research. Melissa Taylor, M.D., of the University of Paris-Sud, and colleagues drew blood from 23 pediatric patients with localized solid tumors, 22 with metastatic solid tumors, and 20 subjects without cancers. The investigators measured circulating vascular endothelial growth factor receptor (VEGFR)2+-bone marrow-derived (BMD) progenitor cells and circulating endothelial cells in the blood. More    E-mail article

How Staph Infections Alter Immune System
from Science Daily
Infectious disease specialists at UT Southwestern Medical Center have mapped the gene profiles of children with severe Staphylococcus aureus infections, providing crucial insight into how the human immune system is programmed to respond to this pathogen and opening new doors for improved therapeutic interventions. More    E-mail article

Light Shed on DNA Mechanisms
from Science Daily
By manipulating individual atoms in DNA and forming unique molecules, a Georgia State University researcher hopes to open new avenues in research towards better understanding the mechanisms of DNA replication and transcription, and perhaps leading to new treatments for diseases. More    E-mail article

Revolution' in the High Speed Imaging of Cells
from Laboratory News
Live cell imaging has a problem how do you image fast cellular events without loosing spatial information? The answer, it turns out, is to get your optics in a bit of a spin say Carl Zeiss, who made the first phase contrast microscope. More    E-mail article

Equitech

Why HIV Progresses Faster in Women than in Men With Same Viral Load
from Science Daily
One of the continuing mysteries of the HIV/AIDS epidemic is why women usually develop lower viral levels than men following acute HIV-1 infection but progress faster to AIDS than men with similar viral loads. Now a research has found that a receptor molecule involved in the first-line recognition of HIV-1 responds to the virus differently in women, leading to subsequent differences in chronic T cell activation, a known predictor of disease progression. More    E-mail article

NT-ProBNP Adds Prognostic Value in NSTE-ASC
from Heartwire via Medscape Medical News
N-terminal pro-brain natriuretic peptide was the only one of a panel of biomarkers that added significant prognostic information to conventional risk factors in the six months following non-ST-elevation ACS in a new study. In the study, published in the Journal of the American College of Cardiology, NT-proBNP was independently predictive for adverse outcomes throughout the entire six-month observation period. More    E-mail article

In a Spin
from Laboratory News
Mixing of materials in the laboratory or for smaller production volumes is traditionally done by hand, or the use of some sort of mechanical blade, impellor or paddle to agitate the mix. These are fine in their way - being largely inexpensive, manual or simple powered tool processes - and are adequate for many mixing tasks. More    E-mail article

AlphaVax Announces Results from Initial Testing of Its H1N1 (Swine) Influenza Vaccine
from Medical News Today
AlphaVax, Inc. announced that it has completed process development and preclinical immunogenicity studies of its H1N1 (swine) influenza vaccine and will manufacture clinical trial material by the end of the month. This vaccine has shown good production yields as well as excellent immunogenicity, even after just a single inoculation. More    E-mail article

The Changing Face of Biobanks
from Genome Technology Magazine
As genomics and proteomics become increasingly clinical in nature, the need for excellent sample collections is turning into a major bottleneck to large-scale studies. Repositories are racing to set standards and meet privacy and other concerns in their collections. More    E-mail article




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