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Sirolimus use and cancer incidence among US kidney transplant recipients
American Journal of Transplantation (login required)
Sirolimus has anti-carcinogenic properties and can be included in maintenance immunosuppressive therapy following kidney transplantation. We investigated sirolimus effects on cancer incidence among kidney recipients. The US transplant registry was linked with 15 population-based cancer registries and national pharmacy claims. Recipients contributed sirolimus-exposed time when sirolimus claims were filled, and unexposed time when other immunosuppressant claims were filled without sirolimus. Cox regression was used to estimate associations with overall and specific cancer incidence, excluding nonmelanoma skin cancers (not captured in cancer registries).
Nominations for ASTS committees open
For ASTS members looking to be more active in the Society, one good way is to nominate yourself for an ASTS committee! You can also nominate someone else you feel is a good fit for a particular committee. Nominations are due by 5 p.m. Eastern on Feb. 2, 2015.
New policies added to policy library
New policies have been added to the ASTS Transplant Center Policy Library! The library is available for purchase as an annual subscription service.
WTC OnDemand free to ASTS members
WTC OnDemand is your online portal to educational information from a variety of sessions from the World Transplant Congress. This portal allows you to view Congress sessions virtually, and access is free to ASTS members!
Study: Candidates feel unworthy of their new organs
Patients with chronic kidney disease worry about the long-term consequences for potential donors and frequently feel unworthy of such a self-sacrificing gift, Camilla Hanson and her colleagues reported online Dec. 1 in Transplantation.
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60 years ago today, a Brigham surgeon kickstarted the field of organ transplantation
Sixty years ago today, at 9:53 in the morning, 23-year-old Ronald Herrick's healthy left kidney arrived in the main operating room at the the Peter Brent Brigham Hospital — now Brigham and Women's Hospital. On the operating table lay Ronald's identical twin brother, Richard, in the throes of renal failure. Upon the kidney’s arrival, the day’s lead surgeon Joseph Murray launched into a technique he’d perfected in over a hundred trial runs in dogs over the course of two years, tucking the kidney neatly into Richard’s lower right abdomen and stitching it into the plumbing of nearby arteries and veins.
The optimal therapy of calcineurin inhibitors for pregnancy in kidney transplantation
Clinical Transplantation (login required)
We investigated the effects of pregnancy and delivery on renal function in transplant recipients and the relationship between doses of immunosuppressants and blood drug levels during pregnancy in 75 women with 88 deliveries. Significant serum creatinine elevation was found in eight deliveries. In the remaining 80 cases, serum creatinine was reduced by an average of 0.14 mg/dL and returned to pre-pregnant levels after delivery.
Universal prophylaxis or preemptive strategy for cytomegalovirus disease after liver transplantation: A systematic review and meta-analysis
American Journal of Transplantation (login required)
We systematically reviewed and meta-analyze the efficacy of universal prophylaxis (UP) and preemptive (PE) strategies (using ganciclovir or valganciclovir) in preventing cytomegalovirus (CMV) disease (CMD) among liver transplant recipients (LTRs). We performed an electronic search of MEDLINE, EMBASE and the Cochrane Database till December 2013. Studies that assessed UP or PE for preventing CMD in LTRs were included. The risk of bias was assessed using the Newcastle–Ottawa scale. The primary outcome was CMD, secondary outcomes being acute cellular rejection (ACR), graft loss (GL) and mortality. Due to the heterogeneity of comparative studies, an indirect comparison was performed.
Through a glass darkly: Seeking clarity in preventing late kidney transplant failure
Journal of the American Society of Nephrology (login required)
A common lament is that long-term kidney transplant outcomes remain the same despite improvements in early graft survival. To be fair, progress has been made — in both our understanding of chronic injury and modestly, graft survival. However, we are still a long way from actually solving this important and difficult problem. In this review, we outline recent data supporting the existence of several causes of renal allograft loss, the incidences of which peak at different time points after transplantation.
Micafungin noninferior to standard prophylaxis after liver transplantation
Data from the Liver Transplant European Study into the Prevention of Fungal Infection, or TENPIN, suggest that micafungin is noninferior to standard treatments as prophylaxis in liver transplant recipients at high risk for invasive fungal infection. In addition, micafungin (Mycamine, Astellas), an echinocandin drug, was associated with better renal function compared with standard regimens, TENPIN investigators wrote in Clinical Infectious Diseases.
Randomized, double-blind comparison of standard-dose vs. high-dose trivalent inactivated influenza vaccine in pediatric solid organ transplant patients
Pediatric Transplantation (login required)
Children who have undergone SOT mount a lower immune response after vaccination with TIV compared to healthy controls. HD or SD TIV in pediatric SOT was given to subjects 3–17 year and at least six months post-transplant. Subjects were randomized 2:1 to receive either the HD (60 μg) or the SD (15 μg) TIV. Local and systemic reactions were solicited after each vaccination, and immune responses were measured before and after each vaccination.
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