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Some receive unnecessary prioritization for liver transplantation, study says
Medical Xpress
Patients waiting for liver transplants who develop hepatopulmonary syndrome (HPS), a lung disorder associated with end-stage liver disease, are eligible to move up on the wait list. In a new paper published in Gastroenterology, however, Penn Medicine researchers argue the so-called "exception points" given to these patients award some HPS patients unnecessary priority over others on the list, which includes about 17,000 patients.
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SOCIETY NEWS


ASTS Research Grants: Call for reviewers
ASTS
The ASTS Grants Review Committee is looking for people with research and funding experience to review Research Grant applications. If you are a seasoned grant reviewer and/or funded recipient, please consider participating. Email asts@asts.org if you are interested.
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Last call for ASTS Research Grant applications!
ASTS
Research grant applications are due Tuesday, Feb. 11, 2014, at 5 p.m. Eastern. Eligibility requirements and applications are available online.
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PRODUCT SHOWCASE
  SRTR Monitoring in Real-Time
XynManagement provides an integrated solution for transplant centers to identify SRTR risk, track outcomes and improve performance. XynManagement’s HIPPA-compliant, cloud-based software platform improves data capture, ensuring your data reflect the true risk of transplants performed. Using simple, effective graphics, the system predicts risk at the individual patient level and assesses program-wide risk on future SRTR reports.
 


Get the member rate at WTC
ASTS
Registration for the 2014 World Transplant Congress is now open, but you must be current on your ASTS dues to register at the member rate. 2014 ASTS membership dues invoices were sent out late last year and dues payments were due Dec. 31, 2013.
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TOP NEWS


Utility of gene expression profiling score variability to predict clinical events in heart transplant recipients
Transplantation (login required)
Gene expression profiling test scores have primarily been used to identify heart transplant recipients who have a low probability of rejection at the time of surveillance testing. It has been hypothesized that the variability of gene expression profiling test scores within a patient may predict risk of future events of allograft dysfunction or death.
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Obese patients with diabetes face higher liver transplant morbidity
Healio
Morbidity after liver transplantation increased among obese patients with diabetes, according to researchers. "There is much evidence on post-transplant obesity and metabolic syndrome. However, the impact of pre-transplant obesity, hypertension and coronary artery disease on post-transplant outcomes has received less attention and is the focus of our study," Adam S. J. R. Bartlett, MBChB, PhD, FRACS, of the New Zealand Liver Transplant Unit at Auckland City Hospital, said in a press release.
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Study: Prerecovery liver biopsy in the brain-dead donor
Liver Transplantation (login required)
Prerecovery liver biopsy can potentially to decrease futile recovery and increase utilization of marginal brain-dead donor livers. A case-control study was conducted to examine the logistics, safety, histological precision and liver utilization associated with PLB in BDDs. Twenty-three cases between January 2008 and January 2013 were compared to two groups: 48 sequential and 69 clinically matched controls.
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Donor hemodynamic profile presages graft survival in donation after cardiac death liver transplantation
Liver Transplantation (login required)
Obligatory exposure to a period of warm ischemia is the defining feature of liver allografts from donation after cardiac death (DCD) donors. Authors explored novel methods for characterizing the dynamic aspects of donor warm ischemia that might be useful in assessing organ quality. The hemodynamic profile during donor warm ischemia was retrospectively studied for 110 Maastricht category III DCD donors.
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Drug shows promise for posttransplant new-onset diabetes
Renal & Urology News
In a small study, sitagliptin showed short-term efficacy and safety in the treatment of new-onset diabetes after renal transplantation. Dr. Thea Anine Strom Halden of Oslo University Hospital in Norway, and colleagues studied 19 long-term stable renal transplant recipients with new-onset diabetes after transplantation. The patients had a median age of 67 years. The investigators randomized patients to receive either sitagliptin 50-100 mg/day for four weeks followed by a sitagliptin-free period of four weeks or vice versa. Results showed that sitagliptin significantly increased first- and second-phase insulin secretion and lowered fasting and postprandial plasma glucose levels. The drug was well tolerated, and the researchers observed no effect on endothelial function and plasma markers of cardiovascular risk and no serious adverse events.
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Study: Pain identifies squamous cell carcinoma in organ transplant recipients
American Journal of Transplantation (login required)
Organ transplant recipients (OTR) are at high risk for cutaneous squamous cell carcinomas (SCC). In this study, authors aimed to define clinically meaningful patient-reported warning signals predicting the presence of invasive SCC. Patient-reported signs and symptoms of 812 consecutively biopsied skin lesions from 410 OTR were determined by questionnaire and physical examination and related to the subsequent biopsy-proven diagnoses.
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TRENDING ARTICLES
Missed our previous issues? See which articles your colleagues read most.

    'Icy' technique improves robotic kidney transplants (redOrbit)
Manufacturing organs (MIT Technology Review)
Revisiting multi-organ transplantation in the setting of scarcity (American Journal of Transplantation)
Acute cellular rejection: Impact of donor-specific antibodies and C4d (Transplantation (login required))
Penn, CHOP study reveals geography plays a major role in access to pediatric kidney transplantation (HealthCanal.com)

Don't be left behind. Click here to see what else you missed.


 

ASTS NewsBrief
Colby Horton, Vice President of Publishing, 469.420.2601
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