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Clinical practice of steroid avoidance in pediatric kidney transplantation
American Journal of Transplantation (login required)
Steroid-avoidance protocols have recently gained popularity in pediatric kidney transplantation. We investigated the clinical practice of steroid avoidance among 9494 kidney transplant recipients at 124 transplant centers between 2000 and 2012 in the Organ Procurement and Transplantation Network database. The practice of steroid avoidance increased during the study period and demonstrated significant variability among transplant centers.
ASTS business meeting tomorrow
ASTS members, please join us for the ASTS Business Meeting and Reception, Tuesday, May 5, at 5:45 p.m. in Room 111A-B of the Pennsylvania Convention Center. You’ll be among the first to know the results of the Officer and Councilor election and have a chance to network with your fellow ASTS members at the reception afterward. And you may receive a VIP package to the 2016 Winter Symposium!
ATC 2016 program proposals due June 5
Program proposals are being accepted for the 2016 American Transplant Congress ATC in Boston. The deadline to submit proposals is June 5, 2015.
QAPI Objective Measures webinar May 13
ASTS, AST and representatives from the CMS Survey and Certification Group are pleased to announce the upcoming webinar in a series on various Quality Assessment and Performance Improvement (QAPI) topics throughout 2015.
HCV RNA in liver explants does not lead to HCV recurrence post-transplant
The presence of hepatitis C virus infection RNA in liver explants did not correlate with a likelihood of hepatitis C recurrence after liver transplantation, according to study results presented at the 2015 International Liver Congress.
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Tolerance of lung allografts achieved in nonhuman primates via mixed hematopoietic chimerism
American Journal of Transplantation (login required)
While the induction of transient mixed chimerism has tolerized MHC-mismatched renal grafts in nonhuman primates and patients, this approach has not been successful for more immunogenic organs. Here, we describe a modified delayed-tolerance-induction protocol resulting in three out of four monkeys achieving long-term lung allograft survival without ongoing immunosuppression. Two of the tolerant monkeys displayed stable mixed lymphoid chimerism, and the other showed transient chimerism. Serial biopsies and post-mortem specimens from the tolerant monkeys revealed no signs of chronic rejection.
Role of bone marrow-derived progenitor cells in de novo liver regeneration in human liver transplants
Liver Transplantation (login required)
The study was designed to examine the hypothesis that circulating progenitor cells play a role in the process of de novo regeneration in human liver transplants and that these cells arise from a cell population originating in, or associated with, the bone marrow and to investigate whether the transplanted liver volume has an effect on the circulating recipient-derived progenitor cells that generate hepatocytes during this process. Clinical data and liver tissue characteristics were analyzed in male individuals who underwent sex-mismatched adult-to-adult living donor liver transplantation using dual left lobe grafts.
After liver failure, a new method of preservation keeps transplant organs healthy
More than 6,000 liver transplants, a delicate operation that hinges on timing, are performed each year in the United States. Now, researchers at the RIKEN Center for Developmental Biology have developed a new technique that extends the time that donated organs last and so should increase the pool of available time-sensitive organs. The procedure cools livers down to 71.6 degrees Fahrenheit while still supplying oxygen, resulting in more successful transplants than the current standard.
Weighing liver transplants for polycystic patients
Having polycystic liver disease can make patients miserable. Their livers can grow to 10 times normal size, causing their abdomens to distend, wreaking havoc with digestion and causing serious events like hemorrhage. One cure is a liver transplant — but since the disease is not fatal and the liver continues to do its job despite the problems the condition causes for patients, physicians face a treatment dilemma.
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Health literacy in patients referred for transplant: Do patients have the capacity to understand?
Clinical Transplantation (login required)
Adequate levels of health literacy are needed for transplant recipients to be able to understand and comply with medical recommendations. However, little is known about health literacy among transplant candidates. Therefore, the purpose of this study was to examine the levels of health literacy and cognitive functioning among patients being evaluated for various types of transplantation.
Researchers solve mystery of deadly transplant infection
Northwestern Memorial Hospital via ScienceDaily
After the death of a patient, a thoracic surgeon has determined the possible cause of a rare infection, likely saving lives of future lung transplant patients. Lungs are one of the most difficult organs to transplant because unlike other organs, lungs are exposed to the external atmospheric elements during normal respiration, leading to possible infection and damage.
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