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Historical matching strategies in kidney paired donation: The 7-year evolution of a Web-based virtual matching system
American Journal of Transplantation (login required)
Failure to convert computer-identified possible kidney paired donation (KPD) exchanges into transplants has prohibited KPD from reaching its full potential. This study analyzes the progress of exchanges in moving from "offers" to completed transplants. Offers were divided into individual segments called 1-way transplants in order to calculate success rates. From 2007 to 2014, the Alliance for Paired Donation performed 243 transplants, 31 in collaboration with other KPD registries and 194 independently. Sixty-one of 194 independent transplants (31.4 percent) occurred via cycles, while the remaining 133 (68.6 percent) resulted from nonsimultaneous extended altruistic donor (NEAD) chains.
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SOCIETY NEWS


ATC 2016 program proposals due June 5
ASTS
Program proposals are being accepted for the 2016 American Transplant Congress ATC in Boston. The deadline to submit proposals is June 5, 2015.
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Registration open for ASTS Leadership Development Program
ASTS
This year's program will be held Sept. 27-30 at Northwestern University's Kellogg School of Management. Transplant clinicians and their administrative counterparts are encouraged to attend this highly customized, one-of-a-kind course together.
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Registration open for OPTN/UNOS Liver forum
ASTS
The OPTN/UNOS Liver and Intestinal Organ Transplantation Committee is sponsoring an educational forum to seek additional input on concepts intended to increase equity in access to liver transplantation. The forum will be held June 22, 2015, at the Loews Chicago O'Hare Hotel and will also be available for live webinar participation.
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TOP NEWS


Adherence to a pedometer-based physical activity intervention following kidney transplant and impact on metabolic parameters
Clinical Transplantation (login required)
The majority of kidney transplant recipients die from cardiovascular events. Physical activity may be a modifiable risk factor for cardiovascular disease following transplant. The goal of our study was to examine adherence to a physical activity intervention following kidney transplant and its impact on metabolic parameters. All patients who received a kidney transplant at our center between December 2010 and December 2011 received usual care (n = 162), while patients transplanted between December 2011 and January 2013 received a 90-day pedometer-based physical activity intervention (n = 145). Metabolic parameters were assessed at four and 12 months post-transplant. Baseline demographics and clinical management were similar between cohorts.
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PRODUCT SHOWCASE
 
You care about your transplant patients. And so do we. That’s why we’re introducing Astellas Cares—a new program that offers you customized tools, educational resources, and comprehensive support to help your patients care for their health. To register, visit AstellasCares.com/Transplant today.
 


Impact of renal impairment on cardiovascular disease mortality after liver transplantation for nonalcoholic steatohepatitis cirrhosis
Liver International
Non-alcoholic steatohepatitis (NASH) is an independent risk factor for cardiovascular disease (CVD) morbidity after liver transplantation, but its impact on CVD mortality is unknown. Researchers sought to assess the impact of NASH on CVD mortality after liver transplantation and to predict which NASH recipients are at highest risk of a CVD-related death following a liver transplant.
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Increasing the number of organ transplants in the US by optimizing donor authorization rates
American Journal of Transplantation (login required)
While recent policies have focused on allocating organs to patients most in need and lessening geographic disparities, the only mechanism to increase the actual number of transplants is to maximize the potential organ supply. We conducted a retrospective cohort study using OPTN data on all "eligible deaths" from Jan. 1, 2008 to Nov. 1, 2013, to evaluate variability in donor service area (DSA)-level donor authorization rates, and to quantify the potential gains associated with increasing authorization rates.
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Time-varying impact of comorbidities on mortality after liver transplantation: A national cohort study using linked clinical and administrative data
BMJ Open
Researchers assessed the impact of comorbidity on mortality in three periods after liver transplantation — first 90 days, 90 days to five years and 5-10 years. Among 3,837 recipients, 45.1 percent had comorbidities.
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Surgical results for recurrent hepatocellular carcinoma after curative hepatectomy: Repeat hepatectomy versus salvage living donor liver transplantation
Liver Transplantation (login required)
The aims of this study were to evaluate the efficacy of repeat hepatectomy (Hx) and salvage living donor liver transplantation (LDLT) for recurrent hepatocellular carcinoma (HCC). A retrospective cohort study was performed to analyze the surgical results of repeat Hx and salvage LDLT for patients with recurrent HCC within the Milan criteria from 1989 to 2012. A total of 159 patients were divided into 2 groups: a repeat Hx group (n = 146) and a salvage LDLT group (n = 13). Operative results and patient prognoses were compared between the 2 groups.
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Advanced melanoma risk greater in organ transplant recipients compared with general population
Healio
Organ transplant recipients had a greater risk of advanced melanomas at diagnosis and melanoma-specific death compared with the general population, according to recently published study results. In a nationwide, population-based study, researchers identified 49 melanomas in organ transplant recipients and 22,496 melanomas in the general public through Swedish health =care registries. Patients had been diagnosed between 1984 and 2008; follow-up was through Dec. 31, 2012.
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Acetaminophen-linked liver failure varies widely in Europe
Medscape
Acetaminophen (paracetamol) overdose caused one fifth of all cases of acute liver failure leading to the need for liver transplant (ALFT) in seven European countries, according to a study published online May 28 in the British Journal of Clinical Pharmacology. However, when researchers compared in-country rates of acetaminophen-linked AFLT they found a 200-fold variation on a per capita basis and a 20-fold variation by amount of drug sold.
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ASTS NewsBrief
Colby Horton, Vice President of Publishing, 469.420.2601
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Esther Cho, Content Editor, 469.420.2671   
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