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Quantifying the risk of incompatible kidney transplantation:
A multicenter study
American Journal of Transplantation
Incompatible live donor kidney transplantation (ILDKT) offers a survival advantage over dialysis to patients with anti-HLA donor-specific antibody (DSA). Program-specific reports (PSRs) fail to account for ILDKT, placing this practice at regulatory risk. Researchers collected DSA data, categorized as positive Luminex, negative flow crossmatch (PLNF), positive flow, negative cytotoxic crossmatch (PFNC) or positive cytotoxic crossmatch (PCC), from 22 centers.
ASTS anniversary reception at WTC
ASTS' year-long celebrations of its 40th anniversary will continue with a special reception during the World Transplant Congress. On Tuesday, July 29, at 7 p.m., ASTS members will gather at the InterContinental Hotel. If you plan to attend, you must RSVP online and pick up your official VIP entry pass at the ASTS booth in the Exhibit Hall. There's no charge, but this event is limited to ASTS members and invited guests. Click here to RSVP (don't forget to log in!) before July 8.
We need your help to meet our goal!
The ASTS Foundation Fund the Future Campaign has a goal of raising $100,000 to fund research grants by June 30. We need your help! Please consider donating any amount.
Looking for your next career move or a new hire?
Look no further than the ASTS Career Center at careercenter.ASTS.org. The Center enables employers to post, manage and update their job listings and company profile anytime day or night, with online payment for faster service. It also allows job seekers to apply for posted jobs or upload their resumes for employers to view.
Calcification propensity test for kidney transplant patients
A blood test that measures the propensity of kidney transplant recipients to develop vascular calcification can be used to identify which patients are at greatest risk for all-cause mortality and graft failure, new research shows. "Renal transplantation improves the prognosis of patients with end-stage renal disease, but the risk of cardiovascular events in these patients remains high, compared with the general population," said investigator Charlotte Keyzer, M.D., from the University Medical Center Groningen in the Netherlands.
Impact of repeat testing of living kidney donors within 14 days of the transplant procedure: A multicenter retrospective survey
Transplant Infectious Disease (login required)
A transmission of human immunodeficiency virus (HIV) from a live kidney donor prompted recommendations by the New York State Department of Health and the U.S. Centers for Disease Control and Prevention that all live donors undergo additional screening for HIV, hepatitis B virus (HBV), and hepatitis C virus (HCV) within 7–14 days of the donation procedure. There are concerns that re-screening will result in delays and cancelled transplants.
Long-term survival after simultaneous pancreas-kidney transplantation with primary function of at least 1 year: A single-center experience
Annals of Transplantation (login required)
Simultaneous pancreas-kidney transplantation has been established as the treatment of choice for type 1 diabetes patients with renal dysfunction. Patient 1-year survival better than 95 percent has been achieved using this kind of transplantation. According to the postoperative complication rate (5 percent mortality), recipients appear to have a survival benefit not earlier than 2 years after transplantation. This study evaluates the long-term benefit of simultaneous pancreas-kidney recipients with functioning grafts after 1 year.
Doctor performs 1st US robotic kidney transplants using a revolutionary cooling technique
Dr.Mahendra Bhandari, CEO of the Vattikuti Foundation, announced that the ongoing foundation-funded robotic kidney transplant project has had the three first robotic kidney transplants successfully completed in Detroit. Robotic Kidney Transplantation with Regional Hypothermia was the first medical study to use a novel method of cooling a donated kidney before it is placed in the patient. The surrounding tissue and kidney are also cooled inside the body with more ice while it is being surgically grafted to the recipient.
The role of hypoxia-inducible factors in organ donation and transplantation: The current perspective and future opportunities
American Journal of Transplantation (login required)
Hypoxia-inducible factors are the universal cellular oxygen-sensitive transcription factors that activate a number of hypoxia responsive genes, some of which are responsible for protective cellular functions. During organ donation, allografts are exposed to significant periods of hypoxia and ischemia. Exploiting this pathway during donor management and organ preservation could prevent and reduce allograft injury and improve the outcomes of organ transplantation.
Survivors of childhood liver transplant at risk of becoming 'skinny fat'
New research reports that survivors of childhood liver transplant remain nutritionally compromised over the long-term. Findings published in Liver Transplantation, a journal of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society, indicate that the recipients' return to normal weight post-transplant was due to an increase in fat mass as body cell mass remained low, indicating a slim body composition with little lean muscle mass or "skinny fat."
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