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 Top Stories

'Quadruple helix' DNA seen in human cells
BBC News    Share    Share on FacebookTwitterShare on LinkedinE-mail article
Cambridge University scientists say they have seen four-stranded DNA at work in human cells for the first time. The famous "molecule of life," which carries our genetic code, is more familiar to us as a double helix. But researchers tell the journal Nature Chemistry that the "quadruple helix" is also present in our cells, and in ways that might possibly relate to cancer. They suggest that control of the structures could provide novel ways to fight the disease. More

Scientists grow kidney tissues from stem cells
The Economic Times    Share    Share on FacebookTwitterShare on LinkedinE-mail article
For the first time, Japanese researchers claim to have successfully grown human kidney tissues from stem cells, a potential breakthrough for millions with damaged organs who are dependent on dialysis. The latest accomplishment is seen as the first step towards transplanting kidney tissue generated from pluripotent stem cells. More

3-photon microscopy improves biological imaging
Chronicle Online    Share    Share on FacebookTwitterShare on LinkedinE-mail article
Scientists may be a step closer to cracking one of the world's most compelling mysteries: the impossible complexity of the brain and its billions of neurons. Cornell University researchers have demonstrated a new way of taking high-resolution, 3-D images of the brain's inner workings through a three-fold improvement in the depth limits of multiphoton microscopy, a fluorescence-based imaging technique with Cornell roots. More
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Scientists seek out cancer cells hiding from treatment
Imperial College London    Share    Share on FacebookTwitterShare on LinkedinE-mail article
Each year 300 British children are diagnosed with acute lymphoblastic leukemia, a cancer of the blood. The majority respond well to current therapies, but the disease returns in a quarter of patients. The long term outlook for adults is much worse, with initial treatments being effective in fewer than half of all patients. Now, scientists hope to improve leukemia treatment by investigating how cancer cells use "hiding places" in the body to avoid chemotherapy drugs. More

Researchers observe cell polarity using advanced microscopy    Share    Share on FacebookTwitterShare on LinkedinE-mail article
Over the past several years, Dr. Rong Li, at the Stowers Institute for Medical Research has been making crucial discoveries about the development of cell polarity — the process by which one side of a cell becomes different from the other side. Such polarity is critical for the functioning of the vast majority of cells. More

Human on Human Detection Kits

GBI Labs’s Klear Human Polymer Detection kits can detect human primary antibody on human tissue with no background. It is a biotin-free system. Special blocking buffer and human antibody enhancer are used to provide excellent sensitivity and high specificity. MORE

 NSH News

2013 NSH teleconference/webinar series
NSH    Share    Share on FacebookTwitterShare on LinkedinE-mail article
NSH teleconferences (now available as webinars) are a great, inexpensive way to provide continuing education to a large number of employees. The cost for each session is the same regardless of the number of attendees. The one-hour session is usually held the fourth Wednesday of the month, beginning at 1 p.m. EST. Occasionally, due to holidays, it may be the third Wednesday of the month. More

NSH launches new portal for tracking continuing education credits
NSH    Share    Share on FacebookTwitterShare on LinkedinE-mail article
Over the past year, NSH staff has been working to develop a new portal for tracking continuing education credits (contact hours) that makes life easier for members and nonmembers. The new portal's user friendly design provides 24-hour access to an individual's education records. In addition, the new portal allows histotechnologists access to add hours to their records, eliminating the waiting period after attending a regional or state society sponsored event. Visit to register with the portal. Complete instructions on how to use it can be found on the NSH website.

New SOX-11 (MRQ-58) for MCL!
SOX-11 expression is specific for the identification of cyclin D1 negative mantle cell lymphoma. SOX-11 is useful due to its high expression in cyclin D1 positive and negative MCL. Many B-cell lymphomas can mimic MCL; therefore, it’s important to have additional antibodies to detect cyclin D1 negative MCL. Learn More.
Slimsette™ Recessed Cover Tissue Cassettes
Available in slotted, biopsy and four compartment versions, the Slimsette™ recessed cover allows for use with lids attached during labeling in cassette printers. Part of the full line of cassettes from LabStorage Systems, Slimsette™ comes in convenient dispenser boxes or preloaded in plastic sleeves for automatic printers. MORE
StatClick™ Specimen Transport Vials
We’ve added a click and removed the leak. Turn the lid until it clicks. Ship with confidence that your samples and your reputation will stay perfectly preserved. To learn more, please visit us at: or contact us at 800-442-3573.

 In the News

Safety of induced stem cells gets a boost
Scientific American    Share    Share on FacebookTwitterShare on LinkedinE-mail article
A paper published in Nature could dispel a cloud over the hopes of turning a patient's own cells into perfectly matched replacement tissues. Scientists first reported in 2007 that a person's cells could be reprogrammed to an embryo-like state, and so could form any type of cell in the body. Medical researchers immediately imagined using these "induced pluripotent stem cells" to create an endless supply of genetically matched replacement tissues to treat a range of diseases. More

Stellaris RNA FISH Probes

Stellaris RNA FISH is a new research technology that enables direct detection, localization and quantification of RNA. The low cost per assay, simple protocol, and the ability to localize mRNA and lncRNA to organelles and cellular structures provides obvious benefits for life science research. Custom and catalogued probes sets available. MORE

Enzyme helps cancer cells avoid genetic instability
Rockefeller University via PhysOrg    Share    Share on FacebookTwitterShare on LinkedinE-mail article
Cancer cells are resourceful survivors with plenty of tricks for staying alive. Researchers have uncovered one of these stratagems, showing how cells lacking the tumor suppressor BRCA1 can resume one form of DNA repair, sparing themselves from stagnation or death. The study appears in the Jan. 21 issue of The Journal of Cell Biology. More

Putting the squeeze on cells
MIT via Science Codex    Share    Share on FacebookTwitterShare on LinkedinE-mail article
Living cells are surrounded by a membrane that tightly regulates what gets in and out of the cell. This barrier is necessary for cells to control their internal environment, but it makes it more difficult for scientists to deliver large molecules such as nanoparticles for imaging, or proteins that can reprogram them into pluripotent stem cells. Researchers from MIT have now found a safe and efficient way to get large molecules through the cell membrane, by squeezing the cells through a narrow constriction that opens up tiny, temporary holes in the membrane. More

3 regenerative medicine companies that could deliver in 2013
Seeking Alpha    Share    Share on FacebookTwitterShare on LinkedinE-mail article
Regenerative medicine, which consists of tissue engineering, cell therapies and healing therapies, is still in its infancy, but is a fast-growing segment in the medical field. The market for regenerative medicine continues to grow worldwide; according to BCC Research, it is expected to accelerate at roughly 12 percent annually. This is a very exciting field for patients and investors as the government and biotech companies are spending hundreds of millions of dollars for stem cell research and development with the goal to not only repair, but in the future actually grow new body parts from heart valves to kidneys. More

Call to contributors
MultiBriefs    Share    Share on FacebookTwitterShare on LinkedinE-mail article
In an effort to enhance the overall content of Under the Microscope, we'd like to include peer-written articles in future editions. As a member of NSH, your knowledge of the industry lends itself to unprecedented expertise. And we're hoping you'll share this expertise with your peers through well-written commentary. Because of the digital format, there's no word or graphical limit and our group of talented editors can help with final edits. If you're interested in participating, please contact Colby Horton to discuss logistics and payment. More

Get your histology CE from MediaLab

Explore our online interactive histology courses, and discover the latest secrets for creating flawless IHC, FISH, special, and routine stains. Complete your annual safety and compliance training hassle free. Document training and get P.A.C.E credits with the included Learning Management System. Get it all with our unlimited annual subscription, available for both individuals and institutions.
Spring Bioscience - BRAF V600E

Spring Bioscience is leading the research industry by pioneering novel, next generation antibodies that can differentiate mutant and normal protein, enabling pathologists to see relevant mutations within their cellular context. Having already released Exon19 and EGFR L858R for exclusive use by Ventana Medical Systems, Spring Bioscience has launched BRAF V600E.
Click here to find out more.
EndNote X6
EndNote® enables you to move seamlessly through your research process with flexible tools for searching, organizing and sharing your research, creating your bibliography and writing your paper. New in X6: Access your research from anywhere and manage your EndNote library from multiple computers with the new EndNoteSync.

Under the Microscope
Colby Horton, Vice President of Publishing, 469.420.2601
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Ashley Whipple, Content Editor, 469.420.2642   
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