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New ways to fund science: Geneticist, panel discuss how research and public interest can intersect
Harvard University via PhysOrg
As research funding dwindles in the United States and abroad, scientists need to rethink their methods for supporting the most promising projects — and how they communicate the meaningful results of that work to the public, according to Nobel Prize-winning geneticist Paul Nurse.
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Combining synthetic and natural toxins could disarm cancer, drug-resistant bacteria
The Medical News
Cancer researchers from Rice University suggest that a new man-made drug that's already proven effective at killing cancer and drug-resistant bacteria could best deliver its knockout blow when used in combination with drugs made from naturally occurring toxins. "One of the oldest tricks in fighting is the one-two punch — you distract your opponent with one attack and deliver a knockout blow with another," said José Onuchic of Rice's Center for Theoretical Biological Physics. "Combinatorial drug therapies employ that strategy at a cellular level.
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Synthetic circuit allows dialling gene expression up or down in human cells
According to a report from the University of Texas MD Anderson Cancer Center, scientists who built a synthetic gene circuit that allowed for the precise tuning of a gene's expression in yeast have now refined this new research tool to work in human cells. "Using this circuit, you can turn a gene from completely off to completely on and anywhere between those two extremes in each cell at once. It's a nice tool if you want to know what happens at intermediate levels of gene expression. There has been no such system so far, but now it is available for mammalian cell research," said senior author Dr. Gábor Balázsi.
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High-content drug screening key for treatment of rare diseases
Tel Aviv University via Laboratory Equipment
Personalized medicine — tailoring diagnostics and treatment according to individual genetics — is a rapidly growing field. Using advanced screening technologies, the dream of offering customized care to each patient is slowly becoming a reality, offering hope to sufferers of rare diseases, who are often left without medical support. But because each disease impacts only a handful of people worldwide, there is no commercial incentive for pharmaceutical companies to fund drug research and development.
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Human on Human Detection Kits

GBI Labs’s Klear Human Polymer Detection kits can detect human primary antibody on human tissue with no background. It is a biotin-free system. Special blocking buffer and human antibody enhancer are used to provide excellent sensitivity and high specificity. MORE


NSH launches new 2-day event — 1st Carolina Symposium
Register today for the first two-day Carolina Symposium being held April 5-6 in Charlotte, N.C. This brand new event, sponsored by the National Society for Histotechnology, the North Carolina Society of Histotechnology and the South Carolina Society of Histology, brings the best of the three organizations offering a fantastic educational program and an Exhibit Fair for one low price. Attendees have the opportunity to earn up to 10.5 continuing education credits. Click here for complete details.
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Preparing for the HT Exam? Don't miss this invaluable review course
Studying for the ASCP Board of Certification Exam is a huge undertaking. That difficulty is increased even more when you are doing it on your own. The amount of time and discipline it takes can be overwhelming. This forum is designed to help guide you through the certification process while reviewing instrumentation, lab math, safety guidelines, special stains, embedding, microtomy, a breakdown of the H&E stain, decalcification methods and the chemicals used in tissue processing. The course will also microscopically identify four major tissue types and 18 different organs. Join us March 9 in Orlando, Fla., as instructor, Shane Jones, conducts this one-day intensive review. Click here for complete details.
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New SOX-11 (MRQ-58) for MCL!
SOX-11 expression is specific for the identification of cyclin D1 negative mantle cell lymphoma. SOX-11 is useful due to its high expression in cyclin D1 positive and negative MCL. Many B-cell lymphomas can mimic MCL; therefore, it’s important to have additional antibodies to detect cyclin D1 negative MCL. Learn More.
Spring Bioscience - BRAF V600E

Spring Bioscience is leading the research industry by pioneering novel, next generation antibodies that can differentiate mutant and normal protein, enabling pathologists to see relevant mutations within their cellular context. Having already released Exon19 and EGFR L858R for exclusive use by Ventana Medical Systems, Spring Bioscience has launched BRAF V600E.
Click here to find out more.
StatClick™ Specimen Transport Vials
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Protein that represses critical checkpoint protein for cellular growth helps drive tumor development
Agency for Science, Technology and Research via Medical Xpress
One of the hallmarks of cancer is unchecked cellular growth. Fortunately, our cells contain a number of tumor suppressor proteins, including the cell cycle regulator p21, to keep cell growth in check. The protection conferred by p21, however, can be overridden by an overactive histone-modifying enzyme called PRMT6. This protein represses p21 expression, thereby promoting tumor growth and preventing senescence in breast cancer cells, A*STAR scientists have found.
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Researchers identify taste stem cells
For decades, taste scientists have attempted to identify the stem or progenitor cells that spawn the different taste receptor cells. The elusive challenge also sought to establish whether one or several progenitors are involved and where they are located, whether in or near the taste bud. "Cancer patients who have taste loss following radiation to the head and neck and elderly individuals with diminished taste function are just two populations who could benefit from the ability to activate adult taste stem cells," said Dr. Robert Margolskee of the Monell Chemical Senses Center, who co-authored a paper published in the journal Stem Cells.
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Sensitive and specific 2-plex RNA-ISH assay
Affymetrix’ QuantiGene® ViewRNA Assays enable single-molecule RNA sensitivity with exceptional specificity in FFPE tissue sections. Assays for your sequence delivered in 1 week. View data.
Milestone was founded in 1988 as a company specializing in advanced microwave instrumentation for analytical and organic chemistry labs. MORE

Diabetes treatment: Stem cells show potential
The California Aggie
In a recently published study, researchers from the UCSD School of Medicine and scientists from the San Diego-based biotech company Viacyte Inc. investigated methods to create endocrine cells, specifically pancreatic T-cells, which are important in treating diabetes through their production of insulin. The study compared two methods of generating endocrine cells from stem cells, in vitro, and through transplantation of immature endocrine cells grown from mice. The malleable nature of the stem cell makes it possible to pursue both of these methods.
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How a mushroom can beat the illness of old age
Business Day
Reishi mushrooms have been used for medicinal purposes in traditional medicine in China, Japan and Korea for at least 2,000 years. Now scientific research is demonstrating Reishi's life-extending properties, as well as its significant ability to stimulate brain neurons, search and destroy cancer cells, and prevent the development of new fat cells in obese individuals.
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Missed last week's issue? See which articles your colleagues read most.

    Bioengineers '3-D print' living human embryonic stem cells for 1st time (Planetsave)
New study shows bio-electric signals can nip cancer in the bud (Firstpost)
Cells lose ability to defend against transposons as they age (The Medical News)
Cells 'flock' to heal wounds: Research team analyzes physics of epithelial cell cooperation (Rice University via PhysOrg)
Blood vessel cells coax colorectal cancer cells into more dangerous state (Bioscience Technology)

Don't be left behind. Click here to see what else you missed.

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EndNote X6
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Stellaris RNA FISH Probes

Stellaris RNA FISH is a new research technology that enables direct detection, localization and quantification of RNA. The low cost per assay, simple protocol, and the ability to localize mRNA and lncRNA to organelles and cellular structures provides obvious benefits for life science research. Custom and catalogued probes sets available. MORE

Under the Microscope
Colby Horton, Vice President of Publishing, 469.420.2601
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