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Personalized medicine experts call on pathology profession to create a new breed of pathologist
Dark Daily
Pathologists are being urged to seize the high ground as the unfolding revolutions in genomics and bioinformatics create unprecedented capabilities to more accurately diagnose patients and guide the selection of appropriate therapies. Two experts in these fields have come together to issue a call to action for the pathology profession, stating that pathologists need to be prepared for the sequencing revolution.
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Targeting cancer with new microscopy technique
For scientists to improve cancer treatments with targeted therapeutic drugs, they need to be able to see proteins prevalent in the cancer cells. This has been impossible, until now. Thanks to a new microscopy technique, University of Akron researcher Dr. Adam Smith, assistant professor of chemistry, has observed how clusters of epidermal growth factor receptor — a protein abundant in lung and colon cancers, glioblastoma and others — malfunctions in cancer cells.
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Sponsored Content

Researchers find controlling element of Huntington's disease
A three molecule complex may be a target for treating Huntington's disease, a genetic disorder affecting the brain. This finding by an international research team including scientists from the German Center for Neurodegenerative Diseases in Bonn and the University of Mainz was published in the online journal Nature Communications. The report states that the so-called MID1 complex controls the production of a protein that damages nerve cells.
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Human on Human Detection Kits

GBI Labs’s Klear Human Polymer Detection kits can detect human primary antibody on human tissue with no background. It is a biotin-free system. Special blocking buffer and human antibody enhancer are used to provide excellent sensitivity and high specificity. MORE

Sunlight-powered prototype sterilizes medical equipment
Laboratory Equipment
Using sunlight, researchers and students at MIT are trying to change how medical equipment is sterilized in remote clinics — and a pilot project in Nicaragua has begun to show promising results. In that nation, a mostly rural population of 6 million is served by some 11 hospitals, dozens of health centers, and some 1,300 "health posts" that provide emergency care, obstetric services and the occasional baby delivery. Most of these posts, staffed by nurse practitioners, either lack equipment to sterilize surgical tools and bandages or have kerosene-powered autoclaves.
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New SOX-11 (MRQ-58) for MCL!

SOX-11 expression is specific for the identification of cyclin D1 negative mantle cell lymphoma. SOX-11 is useful due to its high expression in cyclin D1 positive and negative MCL. Many B-cell lymphomas can mimic MCL; therefore, it’s important to have additional antibodies to detect cyclin D1 negative MCL. Learn More.
Spring Bioscience - BRAF V600E

Spring Bioscience is leading the research industry by pioneering novel, next generation antibodies that can differentiate mutant and normal protein, enabling pathologists to see relevant mutations within their cellular context. Having already released Exon19 and EGFR L858R for exclusive use by Ventana Medical Systems, Spring Bioscience has launched BRAF V600E.
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StatClick™ Specimen Transport Vials

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Team 1st to grow liver stem cells in culture, demonstrate therapeutic benefit
Oregon Health & Science University via Medical Xpress
For decades scientists around the world have attempted to regenerate primary liver cells known as hepatocytes because of their numerous biomedical applications, including hepatitis research, drug metabolism and toxicity studies, as well as transplantation for cirrhosis and other chronic liver conditions. But no lab in the world has been successful in identifying and growing liver stem cells in culture — using any available technique — until now.
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Advanced microscopy techniques give scientists beautiful and unprecedented views inside living cells
This year's Science/AAAS Conference theme was "The Beauty and Benefits of Science" and from press conferences to symposia, the beauty of science was on ample display, as scientists dazzled with amazing images and captivating computer-reconstructed videos of cellular and molecular activity (often depicting real-time dynamics). And they're not just pretty pictures, of course; these images are the result of combined advances in microscopic imaging and fluorescence (protein) technology designed to give scientists the highest resolution viewing of the fundamental mechanics and dynamics of cells and the myriad molecules that operate within them.
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Visualize mRNA and lncRNA in situ
Affymetrix’ QuantiGene® ViewRNA Assay is an established technology that enables localization of RNA with single-molecule sensitivity. Assays automated on Leica BOND RX. View data.
Milestone was founded in 1988 as a company specializing in advanced microwave instrumentation for analytical and organic chemistry labs. MORE

Stem cells found in human parasite, Schistosoma mansoni renews tissue
Science World Report
Most wouldn't consider there to be anything special about a parasitic flatworm. In particular, for the Schistosoma mansoni, you might even consider this little thing flat out disgusting. However, University of Illinois cell and developmental biology professor Phillip Newmark and postdoctoral researcher Jim Collins and their colleagues, have discovered that this disgusting bug renews its tissues with the help of stem cells.
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Bone marrow niches nurture blood stem cells
Washington University in St. Louis via Bioscience Technology
In research that could one day improve the success of stem cell transplants and chemotherapy, scientists have found that distinct niches exist in bone marrow to nurture different types of blood stem cells. Stem cells in the blood are the precursors to infection-fighting white blood cells and oxygen-carrying red blood cells.
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  Stellaris RNA FISH Probes

Stellaris RNA FISH is a new research technology that enables direct detection, localization and quantification of RNA. The low cost per assay, simple protocol, and the ability to localize mRNA and lncRNA to organelles and cellular structures provides obvious benefits for life science research. Custom and catalogued probes sets available. MORE

Sugar-coated scaffolding unlocks stem cell uses
University of Manchester via Laboratory Equipment
Scientists have used sugar-coated scaffolding to move a step closer to the routine use of stem cells in the clinic and unlock their huge potential to cure diseases from Alzheimer's to diabetes. Stem cells have the unique ability to turn into any type of human cell, opening up all sorts of therapeutic possibilities for some of the world's incurable diseases and conditions. The problem facing scientists is how to encourage stem cells to turn into the particular type of cell required to treat a specific disease.
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Missed last week's issue? See which articles your colleagues read most.

    Biologists find key to new anti-malarial drug (Deutsche Welle)
11 scientists getting $33 million from Mark Zuckerberg, Sergey Brin, and the Silicon Valley elite (Fast Company)
Mini microscopes see inside the brains of mice (NBC News)
Biologists create 'zombie cells' in the lab that outperform living counterparts (The Huffington Post UK)
Molecules generated that can halt metastasis of colon cancer (Science Codex)

Don't be left behind. Click here to see what else you missed.

Tweaking gene expression to repair lungs
University of Pennsylvania via Bioscience Technology
Lung diseases such as asthma and chronic obstructive pulmonary disease are on the rise, according to the American Lung Association and the National Institutes of Health. These ailments are chronic, affect the small airways of the lung, and are thought to involve an injury-repair cycle that leads to the breakdown of normal airway structure and function. For now, drugs for COPD treat only the symptoms. Ed Morrisey, professor of Medicine and Cell and Developmental Biology, is looking at how epigenetics controls lung repair and regeneration.
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Antibody test 'inappropriate' without connective tissue symptoms
medwireNews via The Medical News
The positive antinuclear antibody test often is used inappropriately in patients without indications of connective tissue disease, real-world research suggests. The study showed that more than 90 percent of patients referred to a rheumatology clinic following a positive ANA test had no evidence of ANA-associated rheumatic disease.
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Under the Microscope
Colby Horton, Vice President of Publishing, 469.420.2601
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