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Important trends point to cloudy future for clinical laboratories and pathology groups in the US
Dark Daily
By every measure, the clinical laboratory industry is entering a high-stakes period during the next 24 months. Powerful trends are reducing lab budgets and payers are cutting the prices paid for medical laboratory testing. The question on everyone's mind is "will it get better or worse in the months ahead?"
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Better understanding of DNA's 'dark matter' may lead to useful new clinical pathology lab tests
Dark Daily
Growing knowledge about DNA "dark matter" may soon make it possible for clinical laboratories to develop new assays that reveal clinical information useful in diagnosing and guiding therapeutic decisions. In genetics, "dark matter" describes the noncoding areas of DNA. Recent discoveries indicate that dark matter plays more important roles than previously thought.
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Sponsored Content

Zebrafish make a splash in FDA research
U.S. Food and Drug Administration
A tiny fish no wider than your thumbnail may someday make a big difference to your health, but not because it's going to show up on your dinner plate. Zebrafish have been making a splash in the world of scientific research for some time. In 2003, the National Institutes of Health ranked the torpedo-shaped fish the third most important experimental organism after rats and mice, and it's quickly gaining ground.
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New brain cancer treatment is more effective, less toxic
University of California, San Francisco via Bioscience Technology
A Phase 2 clinical trial testing a new protocol for treating a relatively rare form of brain cancer, primary CNS lymphoma, may change the standard of care for this disease, according to doctors at University of California, San Francisco who led the research. Described in the Journal of Clinical Oncology, the trial involved 44 patients who were given a combination of high-dose chemotherapy with immune therapy, rather than the standard combination of chemotherapy with a technique known as whole-brain radiotherapy.
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Looking for similar articles? Search here, keyword BRAIN CANCER.

  Hu-on-Hu & Ms-on-Ms Ab Detection

Klear Human
(D103) for Clinical or Pharmaceutical screens of Humanized or Hu-Antibody on human tissues and Klear Mouse (D52) for screening mouse models (transgenic or xenografts) using Ms-Antibody on mouse tissues. Both kits give the highest specificity with no background. More…

Miniature wireless device provides laboratory-grade blood test
A tiny implantable device developed by Swiss scientists is designed to act as a portable, personal blood testing laboratory to provide immediate analysis of substances that can then be transmitted to a doctor over a cellular phone network. The device, which measures about 14 mm and is implanted just under the skin, is composed of five sensors, a coil for wireless power as well as miniaturized electronics for radio communication, according to an announcement from EPFL. The implant emits radio waves over a safe frequency which then transmits the information via Bluetooth to a mobile phone.
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Researchers create next-generation Alzheimer's disease model
NIH/National Institute of Neurological Disorders and Stroke via ScienceDaily
A new genetically engineered lab rat that has the full array of brain changes associated with Alzheimer's disease supports the idea that increases in a molecule called beta-amyloid in the brain causes the disease, according to a study, published in the Journal of Neuroscience. The study was supported by the National Institutes of Health.
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RNAscope: Visualize Single-Copy RNA

RNAscope FFPE Assay Kits make detecting single-copy RNA easy. RNAscope works for virtually any gene in any tissue!

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Spring Bioscience - BRAF V600E

Spring Bioscience is leading the research industry by pioneering novel, next generation antibodies that can differentiate mutant and normal protein, enabling pathologists to see relevant mutations within their cellular context. Having already released Exon19 and EGFR L858R for exclusive use by Ventana Medical Systems, Spring Bioscience has launched BRAF V600E.
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StatClick™ Specimen Transport Vials

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Experimental vaccine shows promise for ovarian cancer
A novel but preliminary new treatment for ovarian cancer has apparently produced complete remission for one patient with an advanced form of the disease, researchers are reporting. The promising results of a Phase I clinical trial for the immunotherapy approach also showed that seven other women had no measurable disease at the end of the trial, the researchers added.
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Media's role in cell culture success
Genetic Engineering & Biotechnology News
Many cell culture experts will argue that improvements in media and feed have been more responsible than any other factor in raising production titers for therapeutic proteins. While the "nature vs. nurture" argument is far from settled, culture media is at worst the partner of cell-line development in the quest for productivity, safety and efficacy.
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Analyzing mammalian cell culture using Raman spectroscopy
Mammalian cell cultures are complicated processes by which cells are cultured in controlled conditions. In the industrial scenario, mammalian cultures are basic to the manufacture of viral vaccines and other biological products. Chinese hamster ovary cells in the 1980s began revolutionizing mass culture for medicines and continue to remain the workhorse of the industry for therapeutic protein production.
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RNA in situ hybridization assays
QuantiGene® ViewRNA Assays for multiplex in situ hybridization of any gene. Assays enable single-molecule RNA sensitivity with exceptional specificity in FFPE tissue sections. View data.
Milestone was founded in 1988 as a company specializing in advanced microwave instrumentation for analytical and organic chemistry labs. MORE

New genetic link found between normal fetal growth and cancer
Two researchers at the National Institutes of Health discovered a new genetic link between the rapid growth of healthy fetuses and the uncontrolled cell division in cancer. The findings shed light on normal development and on the genetic underpinnings of common cancers. The work, conducted using mouse and human tissue, appears in the issue of the Proceedings of the National Academy of Sciences.
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  Stellaris RNA FISH Probes

Stellaris RNA FISH is a new research technology that enables direct detection, localization and quantification of RNA. The low cost per assay, simple protocol, and the ability to localize mRNA and lncRNA to organelles and cellular structures provides obvious benefits for life science research. Custom and catalogued probes sets available. MORE

Alternative radiation for cancer; intestinal human stem cells; turtle genome
In a recent article, Asian News International reports on promising research about an alternative cancer treatment: boron neutron capture therapy. The lead researcher is M. Frederick Hawthorne, director of the International Institute of Nano and Molecular Medicine of the University of Missouri. The team infused cancerous cells with boron, and then exposed the cells to neutrons, which caused the boron to shatter and lyse the cells. Benign cells were left unharmed.
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AACR: Targeting luminal breast cancer stem cells with trastuzumab blocks metastatic growth in preclinical models
Trastuzumab therapy may be useful for the treatment of luminal breast cancer stem cells, preventing them from growing into macrometastases, according to preclinical results presented at the 2013 American Association for Cancer Research Annual Meeting, held April 6–10 in Washington, D.C. Luminal breast cancers are defined classically by their expression of estrogen and progesterone receptors and by their failure to over express the receptor tyrosine kinase HER2.
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Missed last week's issue? See which articles your colleagues read most.

    Gene therapy cures leukaemia in 8 days (New Scientist)
Scientists discover new DNA regions associated with 3 cancers (Los Angeles Times)
'Bedless hospitals' may reshape clinical pathology laboratory testing (Dark Daily)
Lab automation is happening faster than you think (Laboratory Equipment)
Lab equipment made with 3-D printers could cut costs by 97 percent (The Chronicle of Higher Education)

Don't be left behind. Click here to see what else you missed.

Under the Microscope
Colby Horton, Vice President of Publishing, 469.420.2601
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Ashley Whipple, Content Editor, 469.420.2642   
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