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3 cancer scientists awarded $500,000
The Times Union
Three doctors whose pioneering research helped unlock genetic causes and treatments for cancer were awarded the $500,000 Albany Medical Center Prize in Medicine and Biomedical Research. One of the largest medical prizes in the U.S., the award this years honors decades of work that led to development of a new generation of cancer drugs that, unlike chemotherapy, target specific genetic defects that cause cancer.
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Rat kidneys made in lab point to aid for humans
The New York Times
Researchers at Massachusetts General Hospital in Boston have made functioning rat kidneys in the laboratory, a bioengineering achievement that may one day lead to the ability to create replacement organs for people with kidney disease. The scientists said the rat kidneys produced urine in the laboratory as well as when transplanted into rats. The kidneys were made by stripping donor kidneys of their cells and putting new cells that regenerate tissue into them.
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Stanford researchers create transparent mouse brain
Palo Alto Online
A group of Stanford University researchers have paved the way for increased transparency — literally and scientifically — of one of the least understood organs, the brain. The researchers developed a process that creates a completely intact, transparent mouse brain with three-dimensional views of the brain's fine wiring and molecular structures. In the world of whole-organ imaging, the new process is a giant step forward.
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Scientists reverse memory loss in animal brain cells
Neuroscientists at The University of Texas Health Science Center at Houston have taken a major step in their efforts to help people with memory loss tied to brain disorders such as Alzheimer's disease. Using sea snail nerve cells, the scientists reversed memory loss by determining when the cells were primed for learning. The scientists were able to help the cells compensate for memory loss by retraining them through the use of optimized training schedules.
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  Hu-on-Hu & Ms-on-Ms Ab Detection

Klear Human
(D103) for Clinical or Pharmaceutical screens of Humanized or Hu-Antibody on human tissues and Klear Mouse (D52) for screening mouse models (transgenic or xenografts) using Ms-Antibody on mouse tissues. Both kits give the highest specificity with no background. More…

New method of growing laboratory cells could lead to safer drug trials
Researchers from the University of Southern Denmark have discovered a method which they claim will lead to safer, more accurate laboratory testing of novel drugs on humans. While cells occurring normally in a person's body are capable of exchanging vital information with one another, cells isolated for research purposes lose their ability to communicate, the investigators explain. However, because of this, those laboratory cells believe that they are alone and thus behave differently than they would if they were aware that they were surrounded by other cells.
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NSH presents the Hawaii Symposium
Register today for the first Hawaii Symposium being held Aug. 18 & 19 in Honolulu, Hawaii. This brand new event, sponsored by the National Society for Histotechnology in conjunction with histology professionals of Hawaii brings a fantastic program including general sessions and workshops featuring expert speakers. This symposium will provide you with the tools, advice and guidance you seek in your histology career, plus it's one of the best values for your training dollars, offering a chance to earn up to 12 continuing education credits! Click here for more details and to register now!
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RNAscope: Visualize Single-Copy RNA

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Spring Bioscience - BRAF V600E

Spring Bioscience is leading the research industry by pioneering novel, next generation antibodies that can differentiate mutant and normal protein, enabling pathologists to see relevant mutations within their cellular context. Having already released Exon19 and EGFR L858R for exclusive use by Ventana Medical Systems, Spring Bioscience has launched BRAF V600E.
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Nanodiamonds could improve effectiveness of breast cancer treatment
University of California, Los Angeles via R&D Magazine
Recently, doctors have begun to categorize breast cancers into four main groups according to the genetic makeup of the cancer cells. Which category a cancer falls into generally determines the best method of treatment. But cancers in one of the four groups — called "basal-like" or "triple-negative" breast cancer — have been particularly tricky to treat because they usually don't respond to the "receptor-targeted" treatments that are often effective in treating other types of breast cancer. TNBC tends to be more aggressive than the other types and more likely to recur, and can also have a higher mortality rate.
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UNC study shows promise for uncovering true mechanisms of human stem cell biology
The Medical News
For the first time, researchers at the University of North Carolina at Chapel Hill have isolated adult stem cells from human intestinal tissue. The accomplishment provides a much-needed resource for scientists eager to uncover the true mechanisms of human stem cell biology. It also enables them to explore new tactics to treat inflammatory bowel disease or to ameliorate the side effects of chemotherapy and radiation, which often damage the gut.
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Light at the end of the tunnel: A potential biomarker for a rare form of kidney cancer
By Dr. Kim Blenman
Renal medullary carcinoma is a rare kidney cancer found primarily in individuals with sickle cell disease or the sickle cell trait. It is a highly aggressive cancer predominately presenting in young males with an average age of onset in the mid-20s. Our current medical and scientific understanding of the disease is still quite limited, which results in ineffective therapeutic options. However, recent research may have shed some light on the pathogenesis of the disease.
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Industry Pulse: Do you think the SMARCB1 protein will be the key to treating renal medullary carcinoma?

RNA in situ hybridization assays
QuantiGene® ViewRNA Assays for multiplex in situ hybridization of any gene. Assays enable single-molecule RNA sensitivity with exceptional specificity in FFPE tissue sections. View data.
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'Protein switch' can pinpoint cancer's key players
UNC Health Care via Bioscience Technology
Researchers at the University of North Carolina at Chapel Hill School of Medicine have "rationally rewired" some of the cell's smallest components to create proteins that can be switched on or off by command. These "protein switches" can be used to interrogate the inner workings of each cell, helping scientists uncover the molecular mechanisms of human health and disease.
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Mind-boggling numbers: Genetic expression in the human brain
Science 2.0
President Barack Obama's recently announced effort to map the human brain and existing European efforts like the Human Brain Project are taking direct aim at neurological disorders and diseases. Schizophrenia, Alzheimer's disease, Parkinson's, post-traumatic stress disorders and epilepsy are all, at their worst, debilitating brain malfunctions; the hope is that new money injected into basic research on brain function will improve treatment and recognition.
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  Stellaris RNA FISH Probes

Stellaris RNA FISH is a new research technology that enables direct detection, localization and quantification of RNA. The low cost per assay, simple protocol, and the ability to localize mRNA and lncRNA to organelles and cellular structures provides obvious benefits for life science research. Custom and catalogued probes sets available. MORE

Next-gen sequencing finds brain tumor mutations
St. Jude Children's Research Hospital via Bioscience Technology
The St. Jude Children's Research Hospital, Washington University Pediatric Cancer Genome Project, has identified mutations responsible for more than half of a subtype of childhood brain tumor that takes a high toll on patients. Researchers also found evidence the tumors are susceptible to drugs already in development. The study focused on a family of brain tumors known as low-grade gliomas. These slow-growing cancers are found in about 700 children annually in the U.S., making them the most common childhood tumors of the brain and spinal cord.
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Missed last week's issue? See which articles your colleagues read most.

    Important trends point to cloudy future for clinical laboratories and pathology groups in the US (Dark Daily)
Better understanding of DNA's 'dark matter' may lead to useful new clinical pathology lab tests (Dark Daily)
Zebrafish make a splash in FDA research (U.S. Food and Drug Administration)
Experimental vaccine shows promise for ovarian cancer (HealthDay)
New brain cancer treatment is more effective, less toxic (University of California, San Francisco via Bioscience Technology)

Don't be left behind. Click here to see what else you missed.

Under the Microscope
Colby Horton, Vice President of Publishing, 469.420.2601
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Ashley Whipple, Senior Content Editor, 469.420.2642   
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