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Youngest patient ever gets lab-made windpipe
Bioscience Technology
A 2-year-old girl born without a windpipe now has a new one grown from her own stem cells, the youngest patient in the world to benefit from the experimental treatment. Hannah Warren has been unable to breathe, eat, drink or swallow on her own since she was born in South Korea in 2010. Until the operation at a central Illinois hospital, she had spent her entire life in a hospital in Seoul. Doctors there told her parents there was no hope and they expected her to die.
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Looking for similar articles? Search here, keyword STEM CELL RESEARCH.

Jackson Lab, Children's Medical Center, Hartford Hospital collaborate on new cancer treatment
Hartford Courant
Connecticut cancer patients will participate in a clinical trial in which researchers extract tumor cells, graft them onto mice, and then use the mice as patient avatars so scientists can develop treatment tailored to the individual.
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Discovery reshapes understanding of embryonic development
The University of California, San Francisco
When a baby is born, one of the first things a parent will do is count fingers and toes. New research conducted at UC San Francisco sheds lights on how these specialized digits are formed. In a finding likely to fundamentally reshape biologists' understanding of how cells communicate to each other during development, researchers have found a new type of cellular structure that passes along instructions critical to the formation of the limbs and digits of developing embryos.
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  Spring Bioscience - BRAF V600E

Spring Bioscience is leading the research industry by pioneering novel, next generation antibodies that can differentiate mutant and normal protein, enabling pathologists to see relevant mutations within their cellular context. Having already released Exon19 and EGFR L858R for exclusive use by Ventana Medical Systems, Spring Bioscience has launched BRAF V600E.
Click here to find out more.

Important microscopic technique advanced for biomedical research
TU Delft via R&D Magazine
Scientists at TU Delft have made an important advancement in a new microscopic technique that is widely used in medical research. They demonstrate what the resolution of this localization microscopy is and how the best resolution can be achieved as quickly as possible. Their findings are published online in Nature Methods.
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Tests on cancer cells shows them as 'squishy,' yet tactically strong
R&D Magazine
A team of student researchers and their professors from 20 laboratories around the country have gotten a new view of cancer cells. The work could shed light on the transforming physical properties of these cells as they metastasize, said Jack R. Staunton, a Ph.D. candidate at Arizona State University in the lab of professor Robert Ros, and the lead author of a paper reporting on the topic. Metastasis is a critical step in the progression of cancer. It is when the cancer spreads from one organ or part to another. While much is known about metastasis, it remains an incomplete understanding of the physical biology of the transition.
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Diabetes breakthrough: Newly discovered hormone betatrophin could eliminate insulin injections
International Business Times
Daily insulin injections are the routine for many people with type 2 diabetes. But they might be able to break free from that regimen if a newly discovered hormone realizes its promise. So far, the hormone betatrophin has been examined only in mice, so there's still much work to do before it can even be tested in humans. But hopes are high.
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RNAscope: Visualize Single-Copy RNA

RNAscope FFPE Assay Kits make detecting single-copy RNA easy. RNAscope works for virtually any gene in any tissue!

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Federal spending cuts could hurt America’s cancer research efforts
Pittsburgh Tribune-Review
Remember the sequestration that had politicians in a tizzy a few weeks ago? Turns out the federal spending cuts may have the potential to disrupt important medical research that could affect all our families. The National Institutes of Health, the nation's top health research agency, will see a whopping $2.5 billion in cuts in fiscal year 2013, according to the Congressional Budget Office.
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Japanese researchers announce a point-of-care testing device that detects microRNA in 20 minutes
Dark Daily
Pathologists will be interested to learn that Japanese researchers have developed a second-generation lab-on-a-chip that detects microRNA from a tiny sample volume in only 20 minutes! Their goal is to create a point-of-care device for early detection of cancer.
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Visualize ANY RNA in situ
QuantiGene® ViewRNA Assays enable single-molecule RNA detection in cells, CTCs, tissues and TMAs. Same slide can be visualized under bright field and fluorescence. Learn more.
Milestone was founded in 1988 as a company specializing in advanced microwave instrumentation for analytical and organic chemistry labs. MORE

Dogs detect cancer cells in petri dish
Green Prophet
Researchers at Ben Gurion University in Israel have conducted research proving that specially trained dogs can differentiate the smell of breast cancer cells from noncancerous cells in cell cultures. The concept of using the sniffing ability of dogs to detect cancerous cells first emerged a decade ago in an article in a medical journal about a woman who discovered she had melanoma when her dog repeatedly barked at her tumor. Other individuals have reported similar experiences.
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  Stellaris RNA FISH Probes

Stellaris RNA FISH is a new research technology that enables direct detection, localization and quantification of RNA. The low cost per assay, simple protocol, and the ability to localize mRNA and lncRNA to organelles and cellular structures provides obvious benefits for life science research. Custom and catalogued probes sets available. MORE

Mydicar: New gene therapy trials aim to help people with advanced heart failure
Reuters via The Huffington Post
British scientists are stepping up clinical tests of gene therapy in a bid to help people with advanced heart failure pump blood more efficiently. Researchers said they planned to enroll patients into two new clinical trials using Mydicar, a gene therapy treatment made by privately held U.S. biotech company Celladon.
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  Hu-on-Hu & Ms-on-Ms Ab Detection

Klear Human
(D103) for Clinical or Pharmaceutical screens of Humanized or Hu-Antibody on human tissues and Klear Mouse (D52) for screening mouse models (transgenic or xenografts) using Ms-Antibody on mouse tissues. Both kits give the highest specificity with no background. More…

'Master gene' makes mouse brain look more human
In the cartoon series named after them, Pinky and the Brain, two laboratory mice genetically enhanced to increase their intelligence plot to take over the world — and fail each time. Perhaps their creators hadn't tweaked the correct gene. Researchers have now found a genetic mutation that causes mammalian neural tissue to expand and fold. The discovery may help explain why humans evolved more elaborate brains than mice, and it could suggest ways to treat disorders such as autism and epilepsy that arise from abnormal neural development.
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Missed last week's issue? See which articles your colleagues read most.

    Thermo Fisher to buy Life Technologies for $13.6 billion (Dark Daily)
Video reveals cancer cells' Achilles' heel (The University of Manchester)
New technique holds promise for multiple sclerosis (Case Western Reserve University via PhysOrg)
Innovative cancer treatment has no side effects (Oncology Nurse Advisor)
Scientist shows how small molecules generate better stem cells (HealthCanal)

Don't be left behind. Click here to see what else you missed.

Under the Microscope
Colby Horton, Vice President of Publishing, 469.420.2601
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Ashley Whipple, Senior Content Editor, 469.420.2642   
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