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A step closer to personalized medicine
Genetic Engineering & Biotechnology News
For many cancer patients, it is not clear at the outset which treatment will have the highest chance for success. Many cancer treatments have significant side effects, which can occur whether the drug provides any benefit to the patient or not. If it is possible to know at the outset the likelihood of treatment success for the various available drugs, the patient and doctor can choose a treatment course with the highest chance for success while minimizing the side effects and costs of ineffective treatments.
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Scientists create animal models by altering specific genes associated with a given disease
The Medical News
Whitehead Institute Founding Member Rudolf Jaenisch, who helped transform the study of genetics by creating the first transgenic mouse in 1974, is again revolutionizing how genetically altered animal models are created and perhaps even redefining what species may serve as models. "This new method is a game changer," says Jaenisch, who is also a professor of biology at MIT. "We can now make a mouse with five mutations in just three to four weeks, whereas the conventional way would take three to four years. And it's rather straightforward, probably even easier than the conventional way."
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Researchers find virus able to kill melanoma cells
Skin Inc.
Researchers from Yale University School of Medicine have demonstrated that vesicular stomatitis virus is highly competent at finding, infecting and killing human melanoma cells, both in vitro and in animal models, while having little propensity to infect noncancerous cells.
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A new weapon in the fight against cancer
Science World Report
A group of European research partners attempted to tackle the difficult task of finding a way to detect and capture "circulating tumour cells", a crucial task in the fight against cancer, and succeeded. Cancer causes some 13 percent of deaths worldwide. Of these deaths, some 90 percent are caused not by the original cancer, but by its spread to other parts of the body. These secondary cancers, known as metastases, are most often caused by CTCs which escape from the primary tumour and travel around the body in the bloodstream.
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Group Health Cooperative study uses EHRs and stepped interventions to double rate of colorectal cancer screenings
Dark Daily
Sophisticated use of electronic health records, automated reminder systems, and telephone follow-up can double cancer-screening compliance by consumers. That could mean an increase in testing volumes for clinical laboratories serving clinics using this approach. Researchers at the Group Health Research Institute used electronic health records to identify Group Health Cooperative patients who weren't screened regularly for cancer of the colon and rectum.
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Hawaii Symposium features troubleshooting, IHC/molecular concepts and new GHS training requirements
The National Society for Histotechnology is happy to announce the first Hawaii Symposium sponsored by both the members of Hawaii & NSH. Join us in beautiful Honolulu, Aug. 18 and 19 for a fantastic program including general sessions and workshops featuring NSH's top rated presenters. This symposium is a great value for your training dollars offering a chance to earn up to 12 continuing education credits! Do you have three or more from your office attending? Contact NSH for discount options — 443-535-4060. Learn more.
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Spring Bioscience - BRAF V600E

Spring Bioscience is leading the research industry by pioneering novel, next generation antibodies that can differentiate mutant and normal protein, enabling pathologists to see relevant mutations within their cellular context. Having already released Exon19 and EGFR L858R for exclusive use by Ventana Medical Systems, Spring Bioscience has launched BRAF V600E.
Click here to find out more.
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Cellular alchemy: Converting fibroblasts into heart cells
The Huffington Post
Medieval alchemists devoted their lives to the pursuit of the infamous Philosopher's Stone, an elusive substance that was thought to convert base metals into valuable gold. Needless to say, nobody ever discovered the Philosopher's Stone. Today, we view the Philosopher's Stone as just a myth that occasionally resurfaces in the titles of popular fantasy novels, but cell biologists have discovered their own version of the Philosopher's Stone: The conversion of fibroblast cells into precious heart cells (cardiomyocytes) or brain cells (neurons).
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Study: Chemical safety testing on animals may not be valid for humans
Since Congress mandated testing of new medicines and chemicals on animals back in 1937, billions of laboratory animals have been subjected to a vast number of chemicals and medicinal compounds — all under the entrenched belief that this "safety testing" is translatable to human animals; a concept known as the concordance assumption. But a recent study by a consortium of medical researchers and published on the Proceedings of the National Academy of Sciences website, throws the assumption of concordance into serious doubt.
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Looking for similar articles? Search here, keyword MOUSE TISSUES.

New medicine targets genes behind melanomas
The Shreveport Times
Genes and sunshine helped a life-threatening skin cancer invade Stacey Friday Rachal's body. Rachal, of Goldonna, discovered a year ago that melanoma, the deadliest form of skin cancer, had invaded her brain. Doctors removed the tumor a year ago and discovered more cancer in lymph nodes under her arm. Now a new drug tailored to the genetic mutation behind her type of cancer is keeping the illness at bay.
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Mouth pipetting: An era when this was leading source of clinical laboratory-acquired infections
Dark Daily
Today, cheap and accurate mechanical pipettes are used by clinical pathology laboratories, although mouth pipetting, a dangerous medical lab practice, is still used in developing nations. Mouth pipetting was the topic of a recent blog published by Body Horrors. The blogger recalled a time when clinical laboratory professionals routinely mouth pipetted specimens.
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Missed last week's issue? See which articles your colleagues read most.

    Human brain cells developed in lab, grow in mice (University of California, San Francisco via Medical Xpress)
Discovery helps show how breast cancer spreads (Washington University in St. Louis)
Health insurers spending big dollars to be players in 'big data,' trend has implications for clinical pathology laboratories (Dark Daily)
Scientists discover a brain region that controls aging (Bloomberg Businessweek)
Awards and scholarships (NSH)

Don't be left behind. Click here to see what else you missed.

Brain to be model for supercomputers
Laboratory Equipment
The brain's repute took a big hit in 1997 when an IBM supercomputer defeated world chess champion Gary Kasparov in a match reported around the world. But in the second round, the brain is back. A Sandia National Laboratories-supported workshop in Albuquerque, N.M., called NICE, for Neuro-Inspired Computational Elements workshop, discussed ways to use the brain's superior ability to send electrical signals along massively parallel channels, with multiple intersections at downstream nodes, to handle rapidly changing, high-volume information.
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Stellaris RNA FISH Probes

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Under the Microscope
Colby Horton, Vice President of Publishing, 469.420.2601
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Ashley Whipple, Senior Content Editor, 469.420.2642   
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