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Researchers develop radioactive nanoparticles that target cancer cells
University of Missouri via R&D Magazine
Cancers of all types become most deadly when they metastasize and spread tumors throughout the body. Once cancer has reached this stage, it becomes very difficult for doctors to locate and treat the numerous tumors that can develop. Now, researchers at the University of Missouri have found a way to create radioactive nanoparticles that target lymphoma tumor cells wherever they may be in the body. Michael Lewis, an associate professor of oncology in the MU College of Veterinary Medicine, says being able to target secondary tumors is vital to successfully treating patients with progressive cancers.
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A molecular explanation for age-related fertility decline in women
Medical Xpress
Scientists supported by the National Institutes of Health have a new theory as to why a woman's fertility declines after her mid-30s. They also suggest an approach that might help slow the process, enhancing and prolonging fertility. They found that, as women age, their egg cells become riddled with DNA damage and die off because their DNA repair systems wear out. Defects in one of the DNA repair genes — BRCA1 — have long been linked with breast cancer, and now also appear to cause early menopause.
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Working mice spun from skin cells
Pacific Standard
Embryonic cells are no longer the only cells that can produce live offspring. Two separate Chinese research teams reported recently that they have been able to reprogram skin tissue cells of mice into an embryonic-like state.
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Cheap, fast, accurate home colon cancer test joins growing list of diagnostic tests shifting from medical laboratories to homes
Dark Daily
Steady progress is happening in consumer self-test kits as new diagnostic technology supports at-home kits that produce results with accuracy approaching 90 percent. Because screening for colon cancer represents a potentially huge number of medical laboratory tests each year, many biotech companies are racing to develop reliable test kits that patients can use at home. But to be successful, the test kit must be cheap, easy for a consumer to use, and produce clinically useful results.
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2013 Student Scholarship Winners!
The results of the 2013 NSH Scholarship Awards are in! The four $500 NSH Student Scholarships are graciously sponsored by Newcomer Supply, Sakura Finetek, Sigma Diagnostics and Thermo Fisher Scientific (Irwin S. Lerner Award) and are awarded to deserving students currently enrolled in approved Schools of Histotechnology. Click here to view the winners!
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Spring Bioscience - BRAF V600E

Spring Bioscience is leading the research industry by pioneering novel, next generation antibodies that can differentiate mutant and normal protein, enabling pathologists to see relevant mutations within their cellular context. Having already released Exon19 and EGFR L858R for exclusive use by Ventana Medical Systems, Spring Bioscience has launched BRAF V600E.
Click here to find out more.
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Who updates guidelines for labs dealing with influenza A virus?
Scientist Live
Highly pathogenic avian influenza caused by certain subtypes of influenza A virus in animal populations, particularly chickens, poses a continuing global human public health risk. Direct human infection by an avian influenza A virus was first recognized during the 1997 outbreak in Hong Kong special administrative region of China. Subsequently, human infections with avian strains of the H9 and H7 subtypes have been further documented.
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Understanding molecular mechanisms in cells using AFM, FSD confocal microscopy and TIRF
Understanding the molecular mechanisms behind the remodeling of cells in response to mechanical stimulation is needed to develop therapies for a number of vascular diseases. Studying how cytoskeletal proteins respond to mechano-chemical stimulation have conventionally relied on post-stimulation cell fixation and staining. Since this method provides only static information, researchers started investigating the dynamics of fluorescently tagged proteins using the latest low-light cameras.
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Neuroscience's future: Mice with human brain cells
Scientific American via Salon
Into brains of newborn mice, researchers implanted human "progenitor cells." These mature into a type of brain cell called astrocytes. They grew into human astrocytes, crowding out mouse astrocytes. The mouse brains became chimeras of human and mouse, with the workhorse mouse brain cells — neurons — nurtured by billions of human astrocytes.
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Looking for similar articles? Search here, keyword MOUSE TISSUES.

Caltech biologists show that microRNA-146a protects stem cells during inflammation
The Medical News
When infections occur in the body, stem cells in the blood often jump into action by multiplying and differentiating into mature immune cells that can fight off illness. But repeated infections and inflammation can deplete these cell populations, potentially leading to the development of serious blood conditions such as cancer. Now, a team of researchers led by biologists at the California Institute of Technology has found that, in mouse models, the molecule microRNA-146a acts as a critical regulator and protector of blood-forming stem cells during chronic inflammation.
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'Slow Mohs' advised for lentigo maligna
Skin & Allergy News
"Slow Mohs" has gained near-universal acceptance among skin cancer specialists as a definitive surgical technique for complete removal of lentigo maligna melanoma while simultaneously sparing normal tissue, according to Dr. Ellen Marmur of Mount Sinai School of Medicine, New York. The big advantage that slow Mohs has over standard wide local excision with 0.5- to 1-cm margins is a 5-year cure rate approaching 100 percent. In contrast, standard excision has a recurrence rate of up to 20 percent, she said at the Hawaii Dermatology Seminar.
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1-time cell transplantation cures epilepsy in mice
A neurological implant that has been found to accurately predict the onset of epileptic seizures was recently reported. But a discovery by researchers at the University of California, San Francisco could one day render such a device obsolete. By transplanting a specific type of cell into the brain, the researchers have been able to cure epilepsy in adult mice, with hopes a similar treatment could work in humans.
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Missed last week's issue? See which articles your colleagues read most.

    Researchers find virus able to kill melanoma cells (Skin Inc.)
A new weapon in the fight against cancer (Science World Report)
Mouth pipetting: An era when this was leading source of clinical laboratory-acquired infections (Dark Daily)
New medicine targets genes behind melanomas (The Shreveport Times)

Don't be left behind. Click here to see what else you missed.

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Under the Microscope
Colby Horton, Vice President of Publishing, 469.420.2601
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