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Whole-genome scanning reveals mutations in melanoma DNA 'dark matter,' may offer new source for clinical pathology lab tests
Dark Daily
New discoveries demonstrate important advantages of whole-genome sequencing in investigations of DNA "dark matter" and shed light on the possible origins of cancer. Whole-genome scanning of cancer cells revealed significant mutations in the "dark matter" areas of melanoma DNA. This represents a leap forward in the basic science of cancer. Easier access to whole-genome sequencing means that researchers are poised to mine a rich vein of data that will shine a light on how cells malfunction.
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Confocal microscopy and fluorescence lifetime imaging combined can help detect cancer noninvasively
More effective detection and diagnosis of oral cancer could result from an advance in noninvasive imaging of epithelial tissue by a Texas A&M University researcher who says her research has the potential to change the way doctors initially look for precancerous and cancerous areas in a patient's mouth.
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Shape-shifting nanoparticles flip from sphere to net in response to tumor signal
University of California, San Diego via R&D Magazine
Scientists at the University of California, San Diego have designed tiny spherical particles to float easily through the bloodstream after injection, then assemble into a durable scaffold within diseased tissue. An enzyme produced by a specific type of tumor can trigger the transformation of the spheres into net-like structures that accumulate at the site of a cancer, the team reports in Advanced Materials.
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Stem cell injections improve spinal injuries in rats
UC San Diego Health System
An international team led by researchers at the University of California, San Diego School of Medicine reports that a single injection of human neural stem cells produced neuronal regeneration and improvement of function and mobility in rats impaired by an acute spinal cord injury. Martin Marsala, M.D., professor in the Department of Anesthesiology, with colleagues at UC San Diego and in Slovakia, the Czech Republic and The Netherlands, said grafting neural stem cells derived from a human fetal spinal cord to the rats' spinal injury site produced an array of therapeutic benefits — from less muscle spasticity to new connections between the injected stem cells and surviving host neurons.
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New hope for Crewe mom of 2-year-old with life-limiting illness
Crewe Chronicle
A devoted mom says "all her prayers have been answered" after it was revealed cutting edge research could help extend her two-year-old daughter's life significantly. Three months ago, Sinead Ward, from Crewe, was hit with the devastating news that young Orla was suffering from a rare genetic condition called Ataxi-Telangiectasia. In a double blow to the family, Sinead also discovered that as a carrier of the A-T gene, she now faces a greatly increased risk of developing breast cancer — up to eight times the risk for most women. But the mom of two has now been given renewed hope after hearing that researchers at an eminent Cambridge laboratory will soon begin a research project which could benefit both her and Orla.
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Spring Bioscience - BRAF V600E

Spring Bioscience is leading the research industry by pioneering novel, next generation antibodies that can differentiate mutant and normal protein, enabling pathologists to see relevant mutations within their cellular context. Having already released Exon19 and EGFR L858R for exclusive use by Ventana Medical Systems, Spring Bioscience has launched BRAF V600E.
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Chinese biologists find new method to improve cell reprogramming efficiency
Sequential introduction of the proteins known to reprogram cells could improve the efficiency of cell reprogramming, according to a new study reported in Nature Cell Biology. Currently, researchers use simultaneous introduction method in cell reprogramming, which introduces the proteins to reprogram cells back to a pluripotent, embryonic-like state. Chinese stem-cell biologist Pei Duanqing and colleagues from Chinese Academy of Sciences reported that the sequential introduction of reprogramming proteins outperforms simultaneous introduction.
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Cancer: The No. 1 health concern among middle-income Americans
The Medical News
Cancer is the No. 1 health concern among our country's middle-income Americans, according to a new study released by Washington National Institute for Wellness Solutions. The study, Middle-Income America's Perspectives on Critical Illness and Financial Security, which surveyed 1,001 Americans ages 30 to 66 with an annual household income of between $35,000 and $99,999, found that 79 percent are somewhat concerned or very concerned about a cancer diagnosis, followed by heart disease, stroke, and Alzheimer's disease.
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Researcher admits mistakes in stem cell study
Times LIVE
A blockbuster study in which U.S. researchers reported that they had turned human skin cells into embryonic stem cells contained errors, its lead author has acknowledged. Shoukhrat Mitalipov nevertheless adamantly stood by the conclusions of the study published recently in journal Cell, which reported that human stem cell lines for the first time had been created via cloning. The journal Nature contacted Mitalipov after an anonymous online critic on PubPeer spotted four separate problems in the paper.
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Green-lipped mussels fight exercise-induced asthma
Indiana University via Laboratory Equipment
An Indiana University study has found that a unique omega-3 supplement derived from the New Zealand green-lipped mussel significantly improved lung function and reduced airway inflammation in asthmatics who experience exercise-induced bronchoconstriction, also called exercise-induced asthma. Timothy Mickleborough, professor in the IU School of Public Health-Bloomington, says his findings are similar to his studies involving fish oil but required a much smaller dosage of the supplement.
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Study: Camomile tea could fight superpower of cancer cells
The Huffington Post
A compound that can be found in parsley, celery and camomile tea could halt the spread of cancer cells, scientists claim. Unlike normal cells, cancer cells have a "superpower" to escape death and can inhibit the processes that should cause them to die on a regular basis. However, in a statement, researchers from Ohio State University explain that "apigenin," which can be found in certain plant-based foods, can take away cancer this "superpower."
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Missed last week's issue? See which articles your colleagues read most.

    Researchers develop radioactive nanoparticles that target cancer cells (University of Missouri via R&D Magazine)
Cheap, fast, accurate home colon cancer test joins growing list of diagnostic tests shifting from medical laboratories to homes (Dark Daily)
A molecular explanation for age-related fertility decline in women (Medical Xpress)
'Slow Mohs' advised for lentigo maligna (Skin & Allergy News)
Working mice spun from skin cells (Pacific Standard)

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Under the Microscope
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