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The future of cell reprogramming: Some experts weigh in
Perhaps the biggest takeaway from the recent stem cell conference in Boston is the variety of approaches scientists now have at their disposal to study disease and tissue development, and to test drugs all through reprogramming. Turning one type of the human body's cells into any other cell type.
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New immune disease cripples white cells
MedPage Today
A newly described immunodeficiency syndrome of neutrophil defects, bone marrow fibrosis, nephromegaly and life-threatening infections arises from a genetic mutation that impairs movement of proteins within cells, researchers found. All seven affected children studied had homozygous mutations in VPS45, which encodes for a protein that regulates intracellular traffic of proteins through the endosomal system, Raz Somech, M.D., Ph.D., of Israel's Tel Aviv University, and colleagues reported online in the New England Journal of Medicine.
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Looking for similar articles? Search here, keyword WHITE CELLS.


Tumor 'tweets' influence other cells
Medical News Today
Groundbreaking research from Australia reveals that brain tumors release small bits of information, rather like "tweets," that interact with blood vessel cells in a way that causes them to undergo significant changes. The researchers believe the discovery may lead to new treatments.
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Could this crazy creature help us cure cancer?
The Telegraph
Uncommonly among mammals, mole rats do not get cancer, and recently, scientists announced that they have finally discovered why. They hope the "gloop" that they have identified in the animal could, in due time, form the basis of a host of new medicines to treat not only cancer but diseases ranging from atherosclerosis to arthritis.
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Pre-microscopic Examination Specimen Handling Guidelines in Surgical Pathology Laboratory
In spite of the abundant guidelines and recommendations published for specimen handling and testing in a clinical pathology laboratory, relatively little literature is available for guidance of specimen handling in a surgical pathology laboratory. The following comprehensive table Pre-Microscopic Examination Specimen Handling Guidelines in Surgical Pathology Laboratory (PDF, 853 KB) is intended to serve as a general guideline for proper specimen handling from the time it is taken from the patient to the time a completed slide of the specimen is given to a pathologist for interpretation. This document does not relate to cytologic or clinical pathology samples.
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Spring Bioscience - BRAF V600E

Spring Bioscience is leading the research industry by pioneering novel, next generation antibodies that can differentiate mutant and normal protein, enabling pathologists to see relevant mutations within their cellular context. Having already released Exon19 and EGFR L858R for exclusive use by Ventana Medical Systems, Spring Bioscience has launched BRAF V600E.
Click here to find out more.
RNAscope: Visualize Single-Copy RNA

RNAscope FFPE Assay Kits make detecting single-copy RNA easy. RNAscope works for virtually any gene in any tissue!

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Slimsette™ Recessed Cover Tissue Cassettes

Available in slotted, biopsy and four compartment versions, the Slimsette™ recessed cover allows for use with lids attached during labeling in cassette printers. Part of the full line of cassettes from LabStorage Systems, Slimsette™ comes in convenient dispenser boxes or preloaded in plastic sleeves for automatic printers. MORE

New this year: Any laboratory professional certified by ASCP BOC is welcome to apply for the Career Ambassador Program!
Engage future scientists and leaders of the laboratory when you join the elite group of ASCP Career Ambassadors. As a laboratory scientist certified by ASCP, you have the power to unlock the mysteries of the lab for a whole new generation of scientists — exciting and educating them about careers in laboratory medicine.
The prestigious Career Ambassador Program, in collaboration with Roche, was created to address the laboratory workforce shortage. Select ambassadors in the program are compensated financially (choose from access to the complete ASCP Lab Management University courses or $500 cash for five completed presentations). You'll have the unique opportunity to develop your presentation and communication skills in creative ways. Participants are asked to complete at least five presentations during the 2013-2014 school year.
For more information, eligibility requirements and to apply, please visit:

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Researchers: Sugar solution turns tissues transparent
Science Recorder
According to an article in Science World Report, researchers from the RIKEN Center for Development Biology in Japan have developed a technique to make tissues transparent, using a sugar and water solution called SeeDB. SeeDB helped the researchers transform mouse embryos and brains into transparent tissues in just three days.
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Cutting off the fuel supply: A new approach to the treatment of pancreatic cancer
By Dorothy L. Tengler
Pancreatic cancer kills about 38,000 Americans each year and is considered the leading cause of cancer death. After diagnosis with metastatic disease, patients have a life expectancy of three to six months. It is no wonder that researchers are hard at work searching for new treatment possibilities for such a lethal disease. In a recent landmark study, researchers at NYU School of Medicine have begun to understand the mystery about how pancreatic tumor cells feed themselves. This new understanding could lead to future drug targets.
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Intelsint Vacuum Tissue Processors
A line of TPs capable to conveniently cover the needs of every Histology lab. Our attention is focused on reliability, flexibility, ease of usage, samples protection and user safety.

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Sakura Smart Automation
Our singular focus is to optimize histology workflow. Rapid tissue-processing, Automated Embedding, and real-time specimen review are just a few of our many innovations.

Link between missing enzyme and drug addiction
Medical News Today
A missing brain enzyme increases concentrations of a protein related to pain-killer addiction, according to an animal study. The results were presented at The Endocrine Society's 95th Annual Meeting in San Francisco. Opioids are pain-killing drugs, derived from the opium plant, which block signals of pain between nerves in the body. They are manufactured in prescription medications like morphine and codeine, and also are found in some illegal drugs, like heroin.
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Missed last week's issue? See which articles your colleagues read most.

    Supreme Court invalidates patents on breast and ovarian cancer genes (ACLU)
Biomarker could predict HPV-related oropharyngeal cancer early on (Genetic Engineering & Biotechnology News)
HIV trial to create new immune systems (Bioscience Technology)
2 gene variants may predict who will benefit from breast cancer prevention drugs (National Institutes of Health)
Osteoporosis and cancer no more, all thanks to a single drug (iTech Post)

Don't be left behind. Click here to see what else you missed.

7 predictions for the future of health care technology
Health entrepreneur Sean Mehra writes: "I've got an awesome job. Every day, I envision the future of health care and strategize how innovative technologies can transform how we give and receive care and, ultimately, make the world a happier and healthier place. Here are my seven predictions about where health care is headed."
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StatClick™ Specimen Transport Vials

We’ve added a click and removed the leak. Turn the lid until it clicks. Ship with confidence that your samples and your reputation will stay perfectly preserved. To learn more, please visit us at: or contact us at 800-442-3573.
Hu-on-Hu & Ms-on-Ms Ab Detection

Klear Human
(D103) for Clinical or Pharmaceutical screens of Humanized or Hu-Antibody on human tissues and Klear Mouse (D52) for screening mouse models (transgenic or xenografts) using Ms-Antibody on mouse tissues. Both kits give the highest specificity with no background. More…
Stellaris RNA FISH Probes

Stellaris RNA FISH is a new research technology that enables direct detection, localization and quantification of RNA. The low cost per assay, simple protocol, and the ability to localize mRNA and lncRNA to organelles and cellular structures provides obvious benefits for life science research. Custom and catalogued probes sets available. MORE

Under the Microscope
Colby Horton, Vice President of Publishing, 469.420.2601
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Ashley Whipple, Senior Content Editor, 469.420.2642   
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