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Scientists analyze genetic makeup of human, mouse embryos in unprecedented detail
R&D Magazine
University of California, Los Angeles scientists, in collaboration with teams in China, have used the powerful technology of single-cell RNA sequencing to track the genetic development of a human and a mouse embryo at an unprecedented level of accuracy. The technique could lead to earlier and more accurate diagnoses of genetic diseases, even when the embryo consists of only eight cells.
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After 30 years of overdiagnosis, scientists want to redefine cancer
Medical Daily
Who would have thought that advances in medical technology could potentially lead to unnecessary diagnoses and detrimental treatment plans? In March 2012, the National Cancer Institute held a meeting to evaluate the problem of cancer overdiagnosis, which occurs when harmless tumors are detected and treated as rigorously as harmful ones are, often leading to the demise or injury or patients.
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1st successful transplant of retinas made from embryonic stem cells
For the first time, scientists have successfully transplanted light-detecting cells in the retina, grown from embryonic stem cells, into mice — a feat that could advance similar therapies using the artificial cells to treat degenerative eye diseases toward human trials. The animal transplant is a huge step for embryonic stem cell-based therapies, which have moved slowly to the clinic despite their promise.
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New stem cell gene therapy gives hope to prevent inherited neurological disease
e! Science News
Scientists from The University of Manchester have used stem cell gene therapy to treat a fatal genetic brain disease in mice for the first time. The method was used to treat Sanfilippo — a fatal inherited condition which causes progressive dementia in children — but could also benefit several neurological, genetic diseases. Researchers behind the study, published in the journal Molecular Therapy recently, are now hoping to bring a treatment to trial in patients within two years.
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NSH Hawaii Symposium Preview
Aloha! Join NSH and histology professionals of Hawaii, Aug. 18-19 for a two-day Hawaii Symposium! It will take place in beautiful Honolulu at the Hilton Hawaiian Village Waikiki Beach Resort. Have a chance to earn up to 12 continuing education credits and receive the tools, advice and guidance you seek in your histology career. Choose from four general sessions and eight workshops given by some of the top speakers out there. Plus, don't miss out on two networking opportunities Saturday and Sunday night! Click here for more complete details.
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Spring Bioscience - BRAF V600E

Spring Bioscience is leading the research industry by pioneering novel, next generation antibodies that can differentiate mutant and normal protein, enabling pathologists to see relevant mutations within their cellular context. Having already released Exon19 and EGFR L858R for exclusive use by Ventana Medical Systems, Spring Bioscience has launched BRAF V600E.
Click here to find out more.
Slimsette™ Recessed Cover Tissue Cassettes

Available in slotted, biopsy and four compartment versions, the Slimsette™ recessed cover allows for use with lids attached during labeling in cassette printers. Part of the full line of cassettes from LabStorage Systems, Slimsette™ comes in convenient dispenser boxes or preloaded in plastic sleeves for automatic printers. MORE
Stellaris RNA FISH Probes

Stellaris RNA FISH is a new research technology that enables direct detection, localization and quantification of RNA. The low cost per assay, simple protocol, and the ability to localize mRNA and lncRNA to organelles and cellular structures provides obvious benefits for life science research. Custom and catalogued probes sets available. MORE


Using laser and nanotechnology in the fight against superbugs
By Dorothy L. Tengler
Once antibiotic resistance has been established, it can evolve rapidly because bacteria multiply quickly. So, what can we do to prevent antibiotic resistance? Using antibiotics less frequently is a start, but researchers are helping, too. Thanks to laser and optical technology, a team of physicists at Ecole Polytechnique Federale de Lausanne in Switzerland have built a matchbox-size device that can test for the presence of bacteria in minutes by exploiting the movements of the bacterium's metabolism.
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Looking for similar articles? Search here, keyword SUPERBUGS.

Reprogramming patients' cells offers powerful new tool for studying, treating blood diseases
Science Codex
First produced only in the past decade, human induced pluripotent stem cells are capable of developing into many or even all human cell types. In new research, scientists reprogrammed skin cells from patients with rare blood disorders into iPSCs, highlighting the great promise of these cells in advancing understanding of those challenging diseases — and eventually in treating them. "The technology for generating these cells has been moving very quickly," said hematologist Mitchell J. Weiss, M.D., Ph.D.
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Study: Hepatic stem cells to cure terminal liver diseases
Hepatic stem cells, produced by a patients' own cells, could possibly help cure end-stage liver diseases, a study led by Chinese scientists has shown. The four-year study on mice, led by professor Hu Yiping of the Department of Cell Biology under the Shanghai-based Second Military Medical University, has been published in the latest online version of the U.S. Cell Stem Cell journal. The article, titled "Reprogramming Fibroblasts into Bipotential Hepatic Stem Cells by Defined Factors," marks a breakthrough in China's hepatic stem cells study, said a statement from Hu's team.
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From T cells to therapies
The New York Academy of Sciences
In June, immunologist Dan R. Littman, M.D., Ph.D., received the inaugural Ross Prize in Molecular Medicine at the New York Academy of Sciences. The Ross Prize was established by the Feinstein Institute for Medical Research and Molecular Medicine to honor people whose discoveries change the way medicine is practiced. According to the prize committee, Littman is an active investigator who produces innovative, paradigm-shifting research. He was recognized for his early discoveries, as well as his ongoing research to better understand viral, immune and inflammatory diseases. Here is the interview with Littman, who discusses his research, as well as his predictions and aspirations for the field of molecular medicine.
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Intelsint Vacuum Tissue Processors
A line of TPs capable to conveniently cover the needs of every Histology lab. Our attention is focused on reliability, flexibility, ease of usage, samples protection and user safety.

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Sakura Smart Automation
Our singular focus is to optimize histology workflow. Rapid tissue-processing, Automated Embedding, and real-time specimen review are just a few of our many innovations.

Researchers uncover how a potent compound kills prostate cancer cells
Medical Xpress
One major hallmark of cancer cells is their ability to survive under stressful conditions. A new study spearheaded by researchers at Sanford-Burnham Medical Research Institute reveals how a promising anticancer compound called SMIP004 specifically kills prostate cancer cells by compromising their ability to withstand environmental stress.
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The promise of stem cells
UCLA Today
Stem cells are the body's "master" cells. They have two unique abilities: They can proliferate virtually without limit to produce an essentially infinite supply of their unspecialized cellular selves, and they can differentiate to produce any other cell types that can be used to repair or replace worn-out or damaged tissues. Combine those two superpowers, and you've got the proverbial medical magic bullet.
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Missed last week's issue? See which articles your colleagues read most.

    Proposed Medicare cuts would significantly impact independent laboratories (JD Supra)
Focus on: Histology (ADVANCE for Administrators of the Laboratory)
Dissent over a device to help find melanoma (The New York Times)
7 things you need to know now about ICD-10 (By Charlotte Bohnett)
Can aspirin help prevent colon cancer? (The Boston Globe)

Don't be left behind. Click here to see what else you missed.

Automated techniques for respiratory virus detection
By Dr. Afsaneh Motamed-Khorasani
Viral infection can lead to many respiratory problems including acute respiratory infection, which is one of the main causes of morbidity and mortality worldwide. Most of the advances in clinical virology have been focused on nucleic acid amplification to detect the respiratory viruses, which has become the gold standard for the diagnosis of acute respiratory infection of viral etiology. Meanwhile, many studies were conducted to reduce the hands-on time for the assays. The main strategies studied included stepwise and full automation.
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RNAscope: Visualize Single-Copy RNA

RNAscope FFPE Assay Kits make detecting single-copy RNA easy. RNAscope works for virtually any gene in any tissue!

• Exquisite sensitivity & specificity
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Hu-on-Hu & Ms-on-Ms Ab Detection

Klear Human
(D103) for Clinical or Pharmaceutical screens of Humanized or Hu-Antibody on human tissues and Klear Mouse (D52) for screening mouse models (transgenic or xenografts) using Ms-Antibody on mouse tissues. Both kits give the highest specificity with no background. More…
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