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NSH Laborartory Webinar — Basic in situ Hybridization Theoretical Background
1-2 pm, Sept. 23
Presented by: Traci DeGeer, Ventana Medical Systems, Oro Valley, Arizona
Molecular techniques are becoming more common in today's histology laboratories. Whether the laboratory is accomplishing these stains by hand or through automated means, it is important that the technician understand the basic molecular biology involved in the staining process. The purpose of this lecture is to teach some of this basic molecular biology. The functional steps of the staining process will also be discussed and how each step can affect the possible outcome of staining. Register now.
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HT/HTL Certification prep study weekend Oct. 3-4
This study weekend designed and presented by Sarah Britton, BS, HTL(ASCP)cm, program director at William Beaumont Hospital in Royal Oak, Missouri, is designed to help guide you through the certification process.
Day 1: Focus on the HT
The first day will be a discussion of routine Histotechnology. We will start from the beginning with Fixation then discuss Processing, Decalcification, Embedding, Microtomy, Routine Staining and then the bulk of the time will be spent on Special Stains. During the special stain portion there will be a review of the chemical theory behind staining and a review of specimen requirements (fixative, processing, section thickness, etc). Included in that discussion will be a thorough review of the stains listed on the ASCP BOC content outline under summary of stains.
Day 2: Focus on the HTL
The second day will be special techniques and HTL exam specific topics. We will examine the process of tissue prep for EM and discuss what makes it different from routine histochemical staining. Time will be spent on microtomy equipment used, dyes used for light microscopy, metals used for electron microscopy and how the electron microscope works. Next there will be a discussion on enzyme histochemistry, with a focus on muscle enzyme histochemical staining. In this section we will discuss proper tissue prep methods for enzyme staining, the different types of enzymes and the most commonly used stains for diagnosing muscle disease. In the IHC portion we will discuss the purpose of using IHC, the process of staining tissue using various methods and information about antibodies commonly used for staining. There will also be a brief discussion of In Situ Hybridization. This final topic will be a short introduction to regulatory agencies in the laboratory. Register today!

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  GBI Cost Effective Products

GBI Labs produces the largest selection of secondary detection kits, from single to multiple detection kits, with wide range host species. We provide FREE samples to 1st time users. Staining with our kits results in similar or better sensitivity than other detection kits on the market with 20%-30% cost less.


Drastic changes proposed for clinical research rules
The National Law Review
The U.S. Department of Health and Human Services and 15 other Federal Departments and Agencies have announced a proposal to update the Federal Policy for the Protection of Human Subjects known as the "Common Rule," originally promulgated in 1991.
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Health insurers balk at paying for multigene panels while clinical pathology labs and physicians pursue evidence of clinical utility
Dark Daily
A conflict is building between patients and health insurers over the reluctance among health plans to pay for new, expensive molecular diagnostic assays and genetic tests that clinical laboratory companies offer. This conflict has caught the attention of the nation's media.
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  Hassle Free Block Storage Cabinet

Avantik Biogroup is proud to introduce another Customer Requested Quality Innovation for Histology...the Avantik Biogroup Block Storage Cabinet! We introduced Hassle-Free Drawer Technology with Interlocking Stackability and More Clearance between the top of the blocks and the drawers to achieve the industry's first Jam-Free, Hassle-Free Block Storage Cabinet!

Google cloud takes on cancer research with help from its friends
The Broad Institute will use Google Cloud Engine's pre-emptible VMs, Cycle Computing's orchestration and machine learning to parse cancer cell and genetic data.
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HIV may kill majority of cells by a method overlooked for years
New Scientist
Until recently, we thought HIV largely spread through the body as free-floating particles. Now we know that the virus can infect immune cells by being pumped directly from one cell into another, during brief connections between the two. Research using newer tissue culture methods suggest that crucial white cells called CD4 T-cells are killed by this cell-to-cell transmission up to 95 percent of the time. This mode of infection could be thousands of times more efficient than single viruses infecting cells from the blood.
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ASCO updates policy on genetic testing
Medpage Today
Genetic and genomic testing for cancer susceptibility have introduced a new level of complexity to oncology practice, requiring appropriate education to ensure optimal use for patients, according to an updated policy statement from the American Society of Clinical Oncology.
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A single protein is the root of Dengue's virulence
Dengue, a mosquito-borne virus, infects some 50 million people every year and kills 22,000. Outbreaks in India and Taiwan this year have resulted in thousands of infections and a few dozen deaths. There's no treatment for dengue, and no vaccine that is completely effective. Two teams of scientists, one at Australia's University of Queensland and the other at University of California, Berkeley, think they have found the secret of dengue's virulence: a single protein, called nonstructural protein 1, or NS1, that acts like the poisons released by bacterial infections. The studies are in the recent issue of Science Translational Medicine.
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Clinical trial for 1st oral drug candidate specifically developed for sleeping sickness
Drugs for Neglected Diseases Initiative via Medical Xpress
The Drugs for Neglected Diseases initiative recently announced at the 9th European Congress on Tropical Medicine and International Health in Basel, Switzerland, the successful completion of Phase I human clinical trials for SCYX-7158 (AN5568), the first oral drug candidate specifically developed from the earliest drug discovery stage to combat human African trypanosomiasis, or sleeping sickness, a deadly parasitic disease transmitted by the tsetse fly.
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Employee health codes of conduct
Lab Manager
Workplace wellness can be a positive source of health and empowerment for employees. While many employers have found that wellness programs are ineffective at engaging employees, a new strategy proposed by Cornell University researchers may be just the solution!
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Method of stem cell production may help improve idiopathic pulmonary fibrosis treatment
Researchers test a faster, cheaper way to harvest and grow lung stem cells from patients' own bodies, making them a perfect match, according to a small proof-of-concept trial. The method was tested by researchers at North Carolina State University aiming to treat people with idiopathic pulmonary fibrosis, a disease that causes inflammation in lung tissue that over time becomes thick and stiff. This scarring of tissue negatively affects lung function over time.
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'Medical lab for the home' device can identify cardiac markers in patient's blood, then relay information to physician by smartphone
Dark Daily
Researchers have developed yet another device that takes its readings from a patient's internal bio-markers. This devices analyzes, then transmits the data directly to doctors' smartphones to assist in the diagnosis and treatment of disease. Developers say use of this system may potentially enable doctors to treat patients in their homes without meeting with them in person.
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Missed last week's issue? See which articles your colleagues read most.

    NSH 2015 Annual Symposium/Convention poster winners (NSH)
Another fatal brain disease may come from the spread of 'prion' proteins (Live Science)
Driven to distraction — What causes cyberloafing at work? (Lab Manager)
Clinical labs likely to face challenges under ICD-10 (ICD10monitor)
Clinical lab chain pays $1.8 million to settle charges of double-billing (Sacramento Business Journal)

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Under the Microscope
Colby Horton, Vice President of Publishing, 469.420.2601
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Ashley Whipple, Senior Content Editor, 469.420.2642   
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