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 Top Stories

Rare disease gene may offer diabetes treatment hope
Laboratory Equipment    Share    Share on FacebookTwitterShare on LinkedinE-mail article
The rare disorder Wolfram syndrome is caused by mutations in a single gene, but its effects on the body are far-reaching. The disease leads to diabetes, hearing and vision loss and nerve cell damage that causes motor difficulties and early death. Now, researchers report that they have identified a mechanism related to mutations in the WFS1 gene that affects insulin-secreting beta cells. The finding will aid in the understanding of Wolfram syndrome and also may be important in the treatment of milder forms of diabetes and other disorders. More



Proposed expansion of screening for HIV and hepatitis C could be good news/bad news stories for clinical pathology laboratories
Dark Daily    Share    Share on FacebookTwitterShare on LinkedinE-mail article
Separate recommendations that call for widespread, regular screening for HIV and hepatitis C can be considered to be good news/bad news stories for the clinical laboratory testing industry. That's because the benefits in patient health are likely to incur additional costs for which the healthcare system is not likely to fully reimburse the medical laboratories performing these screening tests. More

New enzyme to fight Alzheimer's disease identified
Medical News Today    Share    Share on FacebookTwitterShare on LinkedinE-mail article
BACE2 is the enzyme that has been found to destroy beta-amyloid, a toxic protein fragment that litters Alzherimer's patients' brains. The new discovery, published in Molecular Neurodegeneration was made by a team at Mayo Clinic, led by Dr. Malcolm A. Leissring, a neuroscientist. The experts tested hundreds of enzymes to determine which could lower beta-amyloid levels. Out of all the enzymes analyzed, BACE2 proved to lower beta-amyloid the most effectively. More

Stellaris RNA FISH Probes

Stellaris RNA FISH is a new research technology that enables direct detection, localization and quantification of RNA. The low cost per assay, simple protocol, and the ability to localize mRNA and lncRNA to organelles and cellular structures provides obvious benefits for life science research. Custom and catalogued probes sets available. MORE


New method for imaging defects in magnetic nanodevices
PhysOrg    Share    Share on FacebookTwitterShare on LinkedinE-mail article
A team of researchers from the NIST Center for Nanoscale Science and Technology, the Royal Institute of Technology in Stockholm and the University of Maryland have demonstrated a microscopy method to identify magnetic defects in an array of magnetic nanostructures. The method represents an important step towards identifying, measuring and correcting the magnetic properties of defective devices in future information storage technologies. More


 In the News


Tissue engineers work to build organs with patient's own cells
The New York Times via The Denver Post    Share    Share on FacebookTwitterShare on LinkedinE-mail article
Andemariam Beyene sat by the hospital window, the low Arctic sun on his face, and talked about the time he thought he would die. Two and a half years ago, doctors in Iceland, where Andemariam Beyene was studying to be an engineer, discovered a golf-ball-size tumor growing into his windpipe. Despite surgery and radiation, it kept growing. In the spring of 2011, when Beyene came to Sweden to see another doctor, he was practically out of options. But the doctor, Paolo Macchiarini, at Sweden's Karolinska Institute, had a radical idea. He wanted to make Beyene a new windpipe, out of plastic and his own cells. More



Cell culture moves into 3rd dimension
Genetic Engineering & Biotechnology News    Share    Share on FacebookTwitterShare on LinkedinE-mail article
Over the past decade, biomedical scientists and engineers have increasingly abandoned conventional cell culture methods, which often confine cells to a monolayer at the bottom of a dish or plate, in favor of novel 3-D techniques. A number of presentations at the 3-D Cell Culture conference revealed the current state of the art — and what is on the horizon. More


New SOX-11 (MRQ-58) for MCL!
SOX-11 expression is specific for the identification of cyclin D1 negative mantle cell lymphoma. SOX-11 is useful due to its high expression in cyclin D1 positive and negative MCL. Many B-cell lymphomas can mimic MCL; therefore, it’s important to have additional antibodies to detect cyclin D1 negative MCL. Learn More.
Human on Human Detection Kits
GBI Labs’s Klear Human Polymer Detection kits can detect human primary antibody on human tissue with no background. It is a biotin-free system. Special blocking buffer and human antibody enhancer are used to provide excellent sensitivity and high specificity. MORE
StatClick™ Specimen Transport Vials
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Regenerative medicine: A peek into the future
The Triple Helix Online    Share    Share on FacebookTwitterShare on LinkedinE-mail article
Regenerative medicine is a growing field that offers the potential to repair and replace damaged cells, tissues and organs by using those that are specially grown. Thus, instead of merely providing treatments to heal damaged body parts, as with transplants, doctors would be able to treat the underlying cause of the disease. Scientists and researchers have worked to fix skin burns, broken bones, diseased hearts, kidneys and organs damaged by cancer, including bladders and livers, among other parts. More



UCSD researchers finds possible treatment for paralysis
U-T San Diego    Share    Share on FacebookTwitterShare on LinkedinE-mail article
University of California-San Diego, researchers have discovered a way to grow nerve fibers in rats with severe spinal cord injuries, a potentially big step toward treating some of the 300,000 Americans who are fully or partially paralyzed. Researchers used stem cells to basically rewire the central nervous system, enabling the rats to regain some movement. The technique, reported in the journal Cell, causes connections from neurons to spread beyond the injury, restoring the ability of the brain and spine to communicate. More

Hopes that new substance will induce cancer cell suicide
Karolinska Institutet via Medical Xpress    Share    Share on FacebookTwitterShare on LinkedinE-mail article
The p53 gene plays a key role in the prevention of cancer, by blocking cell growth and triggering programmed cell death or apoptosis. If, however, p53 has mutated and become defective, the cancer cells can acquire the ability to evade apoptosis and become more resistant to therapy. Researchers at Karolinska Institutet and Karolinska University Hospital have now obtained results from the first tests using a new substance that can restore the function of defective p53 and activate apoptosis in cancer cells. More


Digital Pathology Tools for Biomarker Research
PerkinElmer offers a range of solutions including streamlined TMA & whole slide scanners, patented multispectral imaging and analysis and automated quantitation of biomarkers in tissue. www.perkinelmer.com/tissueimaging
Abcam

Produce publication quality images and benefit from greater sensitivity, improved signal-to-noise ratio as well as reduced background with Abcam’s EXPOSE IHC biotin-free detection systems. Visit us at Booth 349 at the 2012 Convention. MORE


Biology professor finds methods of identifying usable stem cells
The Brown Daily Herald    Share    Share on FacebookTwitterShare on LinkedinE-mail article
As a potential method for producing cells to repair failing systems in human bodies, many scientists are looking to stem cells ­— cells that have the power to differentiate or transform into many different cell types. Scientists already know how to extract stem cells from adult human fat and hope they will someday be able to take a person's own cells and develop the tissues they need. But there is a major constraint to this plan — out of all the cells drawn from adult fat, only a small percentage can successfully turn into the desired cell type. To tackle this challenge, Eric Darling, assistant professor of biology, and his lab are working to produce two methods to sort the useable cells from the chaos. More

DispoCut™ Disposable Dissecting Boards

Lab Storage Systems is proud to offer the DispoCut™ disposable dissecting board. This dissecting board is strong enough to reuse, yet inexpensive enough to throw away. Conveniently printed on both sides in inches and metric measurements. Available in 3 sizes. MORE


Tracking stem cell reprogramming
MIT News    Share    Share on FacebookTwitterShare on LinkedinE-mail article
Several years ago, biologists discovered that regular body cells can be reprogrammed into pluripotent stem cells — cells with the ability to become any other type of cell. Such cells hold great promise for treating many human diseases. These induced pluripotent stem cells are usually created by genetically modifying cells to overexpress four genes that make them revert to an immature, embryonic state. However, the procedure works in only a small percentage of cells. Now, new genetic markers could help make that process more efficient, allowing scientists to predict which treated cells will successfully become pluripotent. More

Human stem cells restore hearing to deaf gerbils in study
HealthDay News via U.S. News & World Report    Share    Share on FacebookTwitterShare on LinkedinE-mail article
Using nerve cells grown from human embryonic stem cells, researchers report that they restored hearing in deaf gerbils. About 80 to 90 percent of deafness is due to problems with the cells in the inner ear, explained senior study author Marcelo Rivolta, a reader in sensory stem cell biology at the University of Sheffield in England. In the inner ear, two types of cells are key to hearing. One type are tiny projections called hair cells, which convert sound vibrations into electrical signals, which then travel along the auditory nerve to the brain. More



Living mammoth cell found in Russia revives cloning hopes
RIA Novosti    Share    Share on FacebookTwitterShare on LinkedinE-mail article
The results of a joint Russian-South Korean expedition in search of clonable mammoth cells in permafrost were summed up at the North-Eastern Federal University, located in the Republic of Yakutia. The expedition found mammoth wool with frozen fat and several bones, including a marrow bone, near the village of Kazachye. When analyzing the bone marrow through a high-resolution microscope, scientists discovered a visibly undamaged karyon, or a cell nucleus. More


Spring Bioscience - BRAF V600E

Spring Bioscience is leading the research industry by pioneering novel, next generation antibodies that can differentiate mutant and normal protein, enabling pathologists to see relevant mutations within their cellular context. Having already released Exon19 and EGFR L858R for exclusive use by Ventana Medical Systems, Spring Bioscience has launched BRAF V600E.
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RDO RAPID DECALCIFIER
RDO Rapid Decalcifier is a major improvement to histological processing procedures. Compared with other commercially available decalcifiers, RDO gently decalcifies specimens in a fraction of the time.
 

Under the Microscope
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