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Whole-genome sequencing trials suggest time has come to bring personalized medicine to cancer field
Dark Daily    Share    Share on FacebookTwitterShare on LinkedinE-mail article
Human whole-genome sequencing of tumors was the source of information for making treatment decisions in a recently published study. For the first time, researchers conducted a large trial involving testing the entire genome of individual breast cancers with the aim of personalized treatment. This is the latest example of how rapid evolution of whole-genome sequencing technology now allows researchers to evaluate clinical applications for human whole-genome sequencing. The results are promising. More

Rabbit Monoclonals for Lymphoma, Prostate
Epitomics has over 150 EP Clones, available in 16 Disease Panels including Lymphoma, and Prostate markers. New antibodies for anatomic pathology include: Aldh1A1, CD30, LIN28, Myogenin PAX5, and S100P. Of particular interest is novel antibody, PAX5 and S100P, distinguished by its high quality FFPE staining. Find out more here.


How to make stem cells: Nuclear reprogramming moves a step forward
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The idea of taking a mature cell and removing its identity (nuclear reprogramming) so that it can then become any kind of cell, holds great promise for repairing damaged tissue or replacing bone marrow after chemotherapy. More

Researchers sequence 1,092 human genomes
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Completing the first phase of the 1000 Genomes Project, scientists report that they have sampled a total of 1,092 individuals from 14 different populations and sequenced their full genomes. The researchers described the feat as a collegial effort to equip biologists and physicians with information that can be used to understand the normal range of human genetic variants so that a patient's disease genome can be interpreted in a broader context. More

Human on Human Detection Kits

GBI Labs’s Klear Human Polymer Detection kits can detect human primary antibody on human tissue with no background. It is a biotin-free system. Special blocking buffer and human antibody enhancer are used to provide excellent sensitivity and high specificity. MORE


Harvard researchers' new DNA barcoding may give pathologists expanded capabilities in fluorescence microscopy
Dark Daily    Share    Share on FacebookTwitterShare on LinkedinE-mail article
Scientists at Harvard University's Wyss Institute for Biologically Inspired Engineering have developed a new DNA barcoding technique. The fluorescence microscopy approach has significant implications for the imaging community. Beyond imaging, however, pathologists will be able to use this same technology when evaluating tissue specimens. The new method could enable simultaneous imaging of many different types of molecules in a single cell, according to Peng Yin, Ph.D., associate professor of Systems Biology at Harvard Medical School. More


 NSH News


CMS coding alert
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To help keep NSH members informed we wanted to provide you with up-to-date information on recent changes in pathology government payment that effects reimbursement of services. For particular specifics and how it may impact your laboratory billing, we recommend that you consult with your own billing service and other professional resources, including the College of American Pathologists from which much of the following is derived. More




 In the News


UM study in JAMA shows donor and patient stem cells can repair heart tissue
HealthCanal.com    Share    Share on FacebookTwitterShare on LinkedinE-mail article
In a study that could help advance the field of regenerative medicine for years to come, the Interdisciplinary Stem Cell Institute at the Miller School has found that mesenchymal stem cells, whether from patients or donors, can treat people whose hearts were previously damaged and scarred after a heart attack. More


DIGITAL HOLOGRAPHY FOR CELL STUDY

NanoAndMore USA provides DHMs from Lyncée tec and Resolution Optics. They sense the change in the liquid content of cells and image in 3D.
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Sensitive and specific 2-plex RNA-ISH assay

Affymetrix’ QuantiGene® ViewRNA Assays enable single-copy RNA sensitivity with exceptional specificity in FFPE tissue sections. From sequence to assay in 1 week. View recent publications.


Scientists find roles for gene switch in cancer development
Genetic Engineering & Biotechnology News    Share    Share on FacebookTwitterShare on LinkedinE-mail article
A research team at the Karolinska Institute and the University of Helsinki has demonstrated that the switches that regulate gene expression play a critical role in the development of cancer. Writing in Science, the investigators looked at a gene region that contains a single nucleotide variant associated with increased risk for cancer. They reported that, by removing this region, tumor formation was greatly reduced. More



Cellular landscaping: Predicting how, and how fast, cells will change
PhysOrg    Share    Share on FacebookTwitterShare on LinkedinE-mail article
A research team at the National Institute of Standards and Technology has developed a model for making quantifiable predictions of how a group of cells will react and change in response to a given environment or stimulus — and how quickly. The NIST model, in principle, makes it possible to assign reliable numbers to the complex evolution of a population of cells, a critical capability for efficient biomanufacturing as well as for the safety of stem cell-based therapies, among other applications. More


New SOX-11 (MRQ-58) for MCL!
SOX-11 expression is specific for the identification of cyclin D1 negative mantle cell lymphoma. SOX-11 is useful due to its high expression in cyclin D1 positive and negative MCL. Many B-cell lymphomas can mimic MCL; therefore, it’s important to have additional antibodies to detect cyclin D1 negative MCL. Learn More.
DispoCut™ Disposable Dissecting Boards

Lab Storage Systems is proud to offer the DispoCut™ disposable dissecting board. This dissecting board is strong enough to reuse, yet inexpensive enough to throw away. Conveniently printed on both sides in inches and metric measurements. Available in 3 sizes. MORE
StatClick™ Specimen Transport Vials
We’ve added a click and removed the leak. Turn the lid until it clicks. Ship with confidence that your samples and your reputation will stay perfectly preserved. To learn more, please visit us at: www.statlab.com/statclick or contact us at 800-442-3573.


Laws will stifle research claim scientists
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VideoBriefScientists are up in arms about legislation stemming from a 2007 treaty signed between Australia and the U.S., saying it will stifle research and hinder international collaboration. More

Spying on cells to make better drugs
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An UC Irvine professor has developed a novel biomedical sensor that will allow researchers to observe cells in their natural habitat. Spying in general is something that is usually frowned upon. In Weian Zhao's University of California laboratory, however, it is both advocated and perfected. More



Blind mole rats' cancer immunity may hold clues to human treatments
The Huffington Post    Share    Share on FacebookTwitterShare on LinkedinE-mail article
There's more than one way for long-lived subterranean rodents to avoid cancer, and they might hold cellular clues to effective treatments in humans. Cell cultures from two species of blind mole rat, Spalax judaei and Spalax golani, behave in ways that render them impervious to the growth of tumors, according to work by Vera Gorbunova at the University of Rochester in New York and her colleagues. And the creatures seem to have evolved a different way of doing this from that observed in their better known and similarly cancer-resistant cousin, the naked mole rat. More


Digital Pathology Tools for Biomarker Research
PerkinElmer offers a range of solutions including streamlined TMA & whole slide scanners, patented multispectral imaging and analysis and automated quantitation of biomarkers in tissue. www.perkinelmer.com/tissueimaging
CAP's Histology Competency Assessment
Learn more about the histology competency assessments through the CAP’s Competency Assessment Program. Also see the self-paced, interactive histology Pro Courses. All courses offer CE.


Measuring molecules with the naked eye
R&D Magazine    Share    Share on FacebookTwitterShare on LinkedinE-mail article
When someone develops liver cancer, the disease introduces a very subtle difference to their bloodstream increasing the concentration of a particular molecule by just 10 parts per billion. That small shift is difficult to detect without sophisticated lab equipment — but perhaps not for long. A new "lab on a chip" designed by Brigham Young University professor Adam Woolley and his students reveals the presence of ultra-low concentrations of a target molecule. More

Avantik Pre-Filled Formalin Containers

These convenient pre-filled formalin containers are designed with a proprietary patented closure… 100% Leak-proof…guaranteed! 95 kPa compliant. Each container is half filled with 10% neutral buffered formalin. Available in the following sizes: 20, 40, 60, 90, 120mL. Call for your free sample. Volume discounts available.


New MRI technique allows detailed imaging of complex muscle structures and muscle damage
Science Daily    Share    Share on FacebookTwitterShare on LinkedinE-mail article
Eindhoven University of Technology and the Academic Medical Center in Amsterdam have together developed a technique that allows detailed 3-D imaging of complex muscle structures of patients. It also allows muscle damage to be detected very precisely. This new technique opens the way to much better and more patient friendly diagnosis of muscular diseases. More


Get your histology CE from MediaLab

Explore our online interactive histology courses, and discover the latest secrets for creating flawless IHC, FISH, special, and routine stains. Complete your annual safety and compliance training hassle free. Document training and get P.A.C.E credits with the included Learning Management System. Get it all with our unlimited annual subscription, available for both individuals and institutions.
Spring Bioscience - BRAF V600E

Spring Bioscience is leading the research industry by pioneering novel, next generation antibodies that can differentiate mutant and normal protein, enabling pathologists to see relevant mutations within their cellular context. Having already released Exon19 and EGFR L858R for exclusive use by Ventana Medical Systems, Spring Bioscience has launched BRAF V600E.
Click here to find out more.
EndNote X6
EndNote® enables you to move seamlessly through your research process with flexible tools for searching, organizing and sharing your research, creating your bibliography and writing your paper. New in X6: Access your research from anywhere and manage your EndNote library from multiple computers with the new EndNoteSync.
 

Under the Microscope
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