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1st road map of human sex-cell development
Scientific American    Share    Share on FacebookTwitterShare on LinkedinE-mail article
The causes of infertility, which affects around 10 percent of couples, are often unknown, but may in some cases result from the body's inability to produce viable gametes — also known as sperm and egg cells. The first study of the development of such "germ cells" from humans could help scientists to learn how to create them in the laboratory instead. More

Independent Assessments Show Optimal Staining

In a series of independent assessments, Epitomics antibodies to MSH6, Her2, CD99, CD20, CK8, and CK19 were rated as "optimally" staining. With our proprietary RabMAb technology, Epitomics continues to develop high quality antibodies and IHC kits for anatomical pathology use. See our full antibody listing and comparisons here.


Geneticist asked to join search for clues in Newtown massacre
Hartford Courant    Share    Share on FacebookTwitterShare on LinkedinE-mail article
As detectives continue to comb through evidence and talk to people who witnessed the mass murder at Sandy Hook Elementary School, the state's chief medical examiner is seeking clues in the gunman's biology. Dr. H. Wayne Carver has asked a geneticist at the University of Connecticut to join in his investigation of the killings. Carver is awaiting toxicology testing results for gunman Adam Lanza, 20, and information that may help answer the question of why Lanza gunned down 20 first-graders and six women at Sandy Hook. More

Adoptive cell transfer: New technique could make cell-based immune therapies for cancer safer, more effective
Memorial Sloan-Kettering Cancer Center via Medical Xpress    Share    Share on FacebookTwitterShare on LinkedinE-mail article
A team led by Dr. Michel Sadelain, director of the Center for Cell Engineering at Memorial Sloan-Kettering Cancer Center, has shown for the first time the effectiveness of a new technique that could allow the development of more-specific, cell-based immune therapies for cancer. Their findings were reported online in Nature Biotechnology. More

Human on Human Detection Kits

GBI Labs’s Klear Human Polymer Detection kits can detect human primary antibody on human tissue with no background. It is a biotin-free system. Special blocking buffer and human antibody enhancer are used to provide excellent sensitivity and high specificity. MORE


Decline in physician-owned independent practices means independent clinical laboratories need to shift strategy
Dark Daily    Share    Share on FacebookTwitterShare on LinkedinE-mail article
Change in who owns office-based physician groups is a trend which can create new winners and losers among the nation's independent medical laboratories Physicians today are more willing to practice medicine as employees than as partners or owners of their medical group. This signals a significant shift in the market for clinical laboratory testing and anatomic pathology services. More

These smartphones are actual 'cell' phones
Discovery News    Share    Share on FacebookTwitterShare on LinkedinE-mail article
Want to get kids doing science? Harness their iPhones. At the American Society for Cell Biology Annual Meeting in San Francisco, Eva Schmid, a professor of bioengineering and biophysics at the University of California, Berkeley, outlined a way for middle school students to use the CellScope, a diagnostic-quality microscope invented by the university's Daniel Fletcher. The microscope is designed to work with smartphones. Slide an iPhone into the specially designed cradle, turn on the camera app and you have a microscope that can magnify at anywhere from 8-120 times. More



Squeeze returns breast cancer cells to normal
Futurity    Share    Share on FacebookTwitterShare on LinkedinE-mail article
This change happens even though the genetic mutations responsible for malignancy remain, setting up a nature-versus-nurture battle in determining a cell's fate. Scientists at the University of California, Berkeley and the Lawrence Berkeley National Laboratory put the squeeze — literally — on malignant mammary cells to guide them back into a normal growth pattern. They presented their findings at the annual meeting of the American Society for Cell Biology in San Francisco. More


 NSH News


2013 NSH teleconference/webinar series
NSH    Share    Share on FacebookTwitterShare on LinkedinE-mail article
NSH teleconferences (now available as webinars) are a great, inexpensive way to provide continuing education to a large number of employees. The cost for each session is the same regardless of the number of attendees. The one-hour session is usually held the fourth Wednesday of the month, beginning at 1 p.m. EST. Occasionally, due to holidays, it may be the third Wednesday of the month. More


DIGITAL HOLOGRAPHY FOR CELL STUDY

NanoAndMore USA provides DHMs from Lyncée tec and Resolution Optics. They sense the change in the liquid content of cells and image in 3D.
MORE
Sensitive and specific 2-plex RNA-ISH assay

Affymetrix’ QuantiGene® ViewRNA Assays enable single-copy RNA sensitivity with exceptional specificity in FFPE tissue sections. From sequence to assay in 1 week. View recent publications.



 In the News


Biological factors, cell behavior drive tumour growth contributing to therapy failure and relapse
The Medical News    Share    Share on FacebookTwitterShare on LinkedinE-mail article
Cancer scientists led by Dr. John Dick at the Princess Margaret Cancer Center have found a way to follow single tumor cells and observe their growth over time. By using special immune-deficient mice to propagate human colorectal cancer, they found that genetic mutations, regarded by many as the chief suspect driving cancer growth, are only one piece of the puzzle. The team discovered that biological factors and cell behavior — not only genes — drive tumor growth, contributing to therapy failure and relapse. More



MRIs reveal signs of brain injuries not seen in CT scans
UCSF via R&D Magazine    Share    Share on FacebookTwitterShare on LinkedinE-mail article
Hospital MRIs may be better at predicting long-term outcomes for people with mild traumatic brain injuries than CT scans, the standard technique for evaluating such injuries in the emergency room, according to a clinical trial led by researchers at UCSF and the San Francisco General Hospital and Trauma Center. Published in the journal Annals of Neurology, the study led by UCSF neuroradiologist Dr. Esther followed 135 people treated for mild traumatic brain injuries over the past two years at one of three urban hospitals with level-one trauma centers. More


New SOX-11 (MRQ-58) for MCL!
SOX-11 expression is specific for the identification of cyclin D1 negative mantle cell lymphoma. SOX-11 is useful due to its high expression in cyclin D1 positive and negative MCL. Many B-cell lymphomas can mimic MCL; therefore, it’s important to have additional antibodies to detect cyclin D1 negative MCL. Learn More.
Slimsette™ Recessed Cover Tissue Cassettes
Available in slotted, biopsy and four compartment versions, the Slimsette™ recessed cover allows for use with lids attached during labeling in cassette printers. Part of the full line of cassettes from LabStorage Systems, Slimsette™ comes in convenient dispenser boxes or preloaded in plastic sleeves for automatic printers. MORE
StatClick™ Specimen Transport Vials
We’ve added a click and removed the leak. Turn the lid until it clicks. Ship with confidence that your samples and your reputation will stay perfectly preserved. To learn more, please visit us at: www.statlab.com/statclick or contact us at 800-442-3573.


In the flesh: The embedded dangers of untested stem cell cosmetics
Scientific American    Share    Share on FacebookTwitterShare on LinkedinE-mail article
When cosmetic surgeon Allan Wu first heard the woman's complaint, he wondered if she was imagining things or making it up. A resident of Los Angeles in her late sixties, she explained that she could not open her right eye without considerable pain and that every time she forced it open, she heard a strange click — a sharp sound, like a tiny castanet snapping shut. After examining her in person, Wu could see that something was wrong: Her eyelid drooped stubbornly, and the area around her eye was somewhat swollen. More



Study: Sulforaphane, compound in broccoli, could fight leukemia
The Huffington Post    Share    Share on FacebookTwitterShare on LinkedinE-mail article
A powerful cancer fighter might be sitting right on your plate. A new study from Baylor College of Medicine researchers shows that a compound found in cruciferous veggies, like broccoli, is able to kill leukemia cells in the laboratory. The findings, published in the journal PLoS ONE, showed that incubating the compound, called sulforaphane, with cells of acute lymphoblastic leukemia caused the cancer cells to die. Plus, the sulforaphane didn't seem to have any kind of effect on healthy cells. More


Digital Pathology Tools for Biomarker Research
PerkinElmer offers a range of solutions including streamlined TMA & whole slide scanners, patented multispectral imaging and analysis and automated quantitation of biomarkers in tissue. www.perkinelmer.com/tissueimaging
CAP/NSH HistoQIP Biopsy Series
Use the CAP's HistoQIP Biopsy Series (HQIPBX) to assess the preparation of H&E stained slides in your laboratory.


Spread of cancer cells may be slowed by targeting of protein
R&D Magazine    Share    Share on FacebookTwitterShare on LinkedinE-mail article
The spread of cancer cells may be slowed by targeting the protein km23-1, according to researchers at Penn State University College of Medicine. A motor protein that transports cargo within the cell, km23-1 is also involved in the movement or migration of cells. Migration is necessary for cancer to spread, so understanding this cell movement is important for development of better cancer treatments. More

Biological pathway that controls the leakiness of blood vessels unraveled
Science Daily    Share    Share on FacebookTwitterShare on LinkedinE-mail article
A research team led by scientists at Mayo Clinic in Florida have decoded the entire pathway that regulates leakiness of blood vessels — a condition that promotes a wide number of disorders, such as heart disease, cancer growth and spread, inflammation and respiratory distress. More

Cell biology: Flushing out fats
Agency for Science, Technology and Research via PhysOrg    Share    Share on FacebookTwitterShare on LinkedinE-mail article
The Wip1 protein is important for survival, but mutations that inactivate it carry some surprising features. "A lack of Wip1 results in an excessive immune reaction to infectious organisms, in some cases killing the host," explains Dmitry Bulavin of the A*STAR Institute of Molecular and Cell Biology, Singapore. He also notes, however, that mice lacking Wip1 are considerably less prone to certain cancers. More


Get your histology CE from MediaLab

Explore our online interactive histology courses, and discover the latest secrets for creating flawless IHC, FISH, special, and routine stains. Complete your annual safety and compliance training hassle free. Document training and get P.A.C.E credits with the included Learning Management System. Get it all with our unlimited annual subscription, available for both individuals and institutions.
Spring Bioscience - BRAF V600E

Spring Bioscience is leading the research industry by pioneering novel, next generation antibodies that can differentiate mutant and normal protein, enabling pathologists to see relevant mutations within their cellular context. Having already released Exon19 and EGFR L858R for exclusive use by Ventana Medical Systems, Spring Bioscience has launched BRAF V600E.
Click here to find out more.
EndNote X6
EndNote® enables you to move seamlessly through your research process with flexible tools for searching, organizing and sharing your research, creating your bibliography and writing your paper. New in X6: Access your research from anywhere and manage your EndNote library from multiple computers with the new EndNoteSync.
 

Under the Microscope
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