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As 2012 comes to a close, NSH would like to wish its members, partners and other industry professionals a safe and happy holiday season. As we reflect on the past year for the industry, we would like to provide the readers of Under the Microscope a look at the most-accessed articles from the year. Our regular publication will resume Jan. 3.

UCLA researcher's death draws scrutiny to lab safety
California Watch    Share    Share on FacebookTwitterShare on LinkedinE-mail article
From Aug. 8, 2012: A 2008 accident in a UCLA laboratory brought into focus the dangers inside university laboratories where students and employees, sometimes working without proper training or supervision, routinely handle toxic, flammable and explosive compounds. As a result of the fatality, the university was cited by the state and has since adopted a series of safety measures. More

Independent Assessments Show Optimal Staining

In a series of independent assessments, Epitomics antibodies to MSH6, Her2, CD99, CD20, CK8, and CK19 were rated as "optimally" staining. With our proprietary RabMAb technology, Epitomics continues to develop high quality antibodies and IHC kits for anatomical pathology use. See our full antibody listing and comparisons here.

Lab-grown meat is 1st step to artificial hamburger
BBC News    Share    Share on FacebookTwitterShare on LinkedinE-mail article
From Feb. 22, 2012: Dutch scientists have used stem cells to create strips of muscle tissue with the aim of producing the first lab-grown hamburger later this year. The aim of the research is to develop a more efficient way of producing meat than rearing animals. More

Viruses recruited as killers of tumors
The New York Times    Share    Share on FacebookTwitterShare on LinkedinE-mail article
From March 21, 2012: In 1951, a 4-year-old boy with leukemia contracted chickenpox. His liver and spleen, swollen by the cancer, soon returned to normal, and his elevated blood cell count fell to that of a healthy child. His doctors at the Laboratory of Experimental Oncology in San Francisco were thrilled by his sudden remission, but the blessing was short-lived. After one month, his leukemia returned and progressed rapidly until the child's death. More

Human on Human Detection Kits

GBI Labs’s Klear Human Polymer Detection kits can detect human primary antibody on human tissue with no background. It is a biotin-free system. Special blocking buffer and human antibody enhancer are used to provide excellent sensitivity and high specificity. MORE

Virtual slides reveal disease in 3-D
University of Leeds via Medical Xpress    Share    Share on FacebookTwitterShare on LinkedinE-mail article
From April 25, 2012: Computing experts and medical researchers at the University of Leeds have developed a fast, easy-to-use way of studying tissue samples in 3-D using "virtual" microscope slides. The novel digital scanning system produces high-resolution, multicolored images that can be rotated and examined from any angle. More

Small babies may weaken mothers' hearts
The New York Times    Share    Share on FacebookTwitterShare on LinkedinE-mail article
From March 21, 2012: A full-term pregnancy with a small baby may cause changes in a woman's cardiovascular system that increase her risk for heart disease later in life, data suggest. Using a nationally representative sample, researchers studied 6,608 women who had delivered full-term babies. Women who had small babies were at about twice the risk for heart disease as those who had not. More

Single cancer cell can produce up to 5 daughter cells
UCLA via Bioscience Technology    Share    Share on FacebookTwitterShare on LinkedinE-mail article
From July 11, 2012: Bioengineers at UCLA have developed a platform to mechanically confine cells, simulating the in vivo three-dimensional environments in which they divide and found that, upon confinement, cancer cells often split into three or more daughter cells. More

Patients' skin cells yield research model for Alzheimer's
HealthDay News via U.S. News & World Report    Share    Share on FacebookTwitterShare on LinkedinE-mail article
From July 18, 2012: Aiming for insights into Alzheimer's disease, scientists have developed a new cellular model for research — one that's sourced from the skin cells of patients but genetically reprogrammed to mimic diseased brain cells. The scientists say their approach might draw on the stem cells of people with Alzheimer's disease as a virtually limitless supply of different types of diseased brain cells for laboratory study. More


NanoAndMore USA provides DHMs from Lyncée tec and Resolution Optics. They sense the change in the liquid content of cells and image in 3D.
Sensitive and specific 2-plex RNA-ISH assay

Affymetrix’ QuantiGene® ViewRNA Assays enable single-copy RNA sensitivity with exceptional specificity in FFPE tissue sections. From sequence to assay in 1 week. View recent publications.

Scientists: Ovary stem cells can produce new human eggs
TIME    Share    Share on FacebookTwitterShare on LinkedinE-mail article
From Feb. 29, 2012: Although it has long been assumed that women are born with all the eggs they will ever have in a lifetime, recent research has hinted that that might not be the case. Now researchers report the strongest evidence yet that women may be able to replenish their supply of eggs after they are born — and perhaps after age or disease might have normally hindered their fertility. More

Scientists uncover lead into premature aging, heart disease
Bioscience Technology    Share    Share on FacebookTwitterShare on LinkedinE-mail article
From May 2, 2012: Scientists have discovered that they can dramatically increase the life span of mice with progeria and heart disease by reducing levels of a protein called SUN1. This research was done by A*STAR's Institute of Medical Biology in collaboration with their partners at the National Institute of Allergy and Infectious Diseases in the United States and the Institute of Cellular and System Medicine in Taiwan. More

New SOX-11 (MRQ-58) for MCL!
SOX-11 expression is specific for the identification of cyclin D1 negative mantle cell lymphoma. SOX-11 is useful due to its high expression in cyclin D1 positive and negative MCL. Many B-cell lymphomas can mimic MCL; therefore, it’s important to have additional antibodies to detect cyclin D1 negative MCL. Learn More.
Slimsette™ Recessed Cover Tissue Cassettes
Available in slotted, biopsy and four compartment versions, the Slimsette™ recessed cover allows for use with lids attached during labeling in cassette printers. Part of the full line of cassettes from LabStorage Systems, Slimsette™ comes in convenient dispenser boxes or preloaded in plastic sleeves for automatic printers. MORE
StatClick™ Specimen Transport Vials
We’ve added a click and removed the leak. Turn the lid until it clicks. Ship with confidence that your samples and your reputation will stay perfectly preserved. To learn more, please visit us at: or contact us at 800-442-3573.

Raising a glass a day to lower stroke risk in women
TIME    Share    Share on FacebookTwitterShare on LinkedinE-mail article
From March 14, 2012: A study offers good news for women who unwind with a cocktail at the end of the day: Light to moderate drinking is associated with lower stroke risk. The report involved 26 years of data on 83,578 women who were part of the long-running Nurses' Health Study — a study of how factors like diet and alcohol consumption may influence women's long-term health. More

Owners of regional independent clinical pathology laboratory companies make plans to visit senators and representatives
Dark Daily    Share    Share on FacebookTwitterShare on LinkedinE-mail article
From Nov. 21, 2012: Recently, an intrepid group of clinical laboratory owners gathered in the nation's capital specifically to visit their senators and representatives. The goal was to educate these elected officials about the tenuous financial condition of independent medical laboratory companies. In particular, ongoing budget cuts to the Medicare Part B Clinical Laboratory Test Fee Schedule are undermining the ability of medical laboratories to deliver top-flight lab test services. More

Digital Pathology Tools for Biomarker Research
PerkinElmer offers a range of solutions including streamlined TMA & whole slide scanners, patented multispectral imaging and analysis and automated quantitation of biomarkers in tissue.
CAP/NSH HistoQIP Biopsy Series
Use the CAP's HistoQIP Biopsy Series (HQIPBX) to assess the preparation of H&E stained slides in your laboratory.

Oncology leaders praise health law ruling, with caveats
OncLive    Share    Share on FacebookTwitterShare on LinkedinE-mail article
From July 2, 2012: Leaders in the oncology care and research communities largely applauded the Supreme Court ruling that upholds the Affordable Care Act, mixing their optimism with a measure of caution over the impact of the contentious healthcare legislation on clinical practice. Organizations dedicated to fighting cancer called the decision a positive development for healthcare providers, researchers, and patients, despite concerns about the ramifications of continued political battling over the law. More

New microscope uses rainbow of light to image blood cell flow
R&D Magazine    Share    Share on FacebookTwitterShare on LinkedinE-mail article
From May 23, 2012: Blood tests convey vital medical information, but the sight of a needle often causes anxiety and results take time. A new device developed by a team of researchers in Israel, however, can reveal much the same information as traditional blood test in real-time, simply by shining a light through the skin. This optical instrument is able to provide high-resolution images of blood coursing through our veins without the need for harsh and short-lived fluorescent dyes. More

A question of freedom for chimpanzees who spend lives in labs
NBC News    Share    Share on FacebookTwitterShare on LinkedinE-mail article
From Feb. 2, 2012: Dr. John VandeBerg, the director of a San Antonio primate research center, says his chimpanzees are treated "with the utmost of reverence," and have a "high quality of life." But that quality of life is a matter of intense debate and part of the emotional argument over whether experimenting on chimps is morally and scientifically justified to save human lives. More

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Spring Bioscience - BRAF V600E

Spring Bioscience is leading the research industry by pioneering novel, next generation antibodies that can differentiate mutant and normal protein, enabling pathologists to see relevant mutations within their cellular context. Having already released Exon19 and EGFR L858R for exclusive use by Ventana Medical Systems, Spring Bioscience has launched BRAF V600E.
Click here to find out more.
EndNote X6
EndNote® enables you to move seamlessly through your research process with flexible tools for searching, organizing and sharing your research, creating your bibliography and writing your paper. New in X6: Access your research from anywhere and manage your EndNote library from multiple computers with the new EndNoteSync.

Under the Microscope
Colby Horton, Vice President of Publishing, 469.420.2601
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Ashley Whipple, Content Editor, 469.420.2642   
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