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Improved overall survival confirmed in long-term follow-up report of Japanese dose-dense paclitaxel trial (JGOG 3016)
The Lancet Oncology
Long-term follow-up results are now available for JGOG 3016, a randomized, controlled trial of standard carboplatin with paclitaxel administered on either a weekly or conventional, every-three-week schedule. The study enrolled 631 women with stage II-IV ovarian, fallopian tube or primary peritoneal cancer following maximal-effort primary cytoreductive surgery. The median overall survival for the entire cohort after a median of 77 months was 100.5 vs 62.2 months (HR = 0.79, P = .039) favoring the dose-dense treatment group. Five-year overall survival was 58.7 percent vs 51.1 percent for dose-dense vs. conventional, respectively. This is an important finding and is a potential new standard of care for first-line chemotherapy for patients with advanced epithelial ovarian cancer.
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Enhanced recovery pathway for gynecologic surgery gets patients back to health faster
Medical Xpress
Patients who had complex gynecologic surgery managed by an enhanced recovery pathway resulted in decreased narcotic use, earlier discharge, stable readmission rates, excellent patient satisfaction and cost savings, according to a Mayo Clinic study. The findings are published in the journal Obstetrics & Gynecology.
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Opinion: Why aren't there more cancer vaccines?
There are exceptions to the rule that late-stage cancers attract more research resources, but many of these exceptions only serve to reinforce the study's findings. For example, there are a lot of clinical trials for treatment of breast cancers of every stage. Call it the Betty Ford–Susan Komen effect — the breast cancer awareness movement has been enormously effective at raising money for research. But within breast cancer types, the general pattern of more trials for metastatic than localized cancers still holds.
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  A Medical ‘Must Have’

Morrow’s Gynecologic Cancer Surgery, 2nd Edition is an invaluable comprehensive surgical text book resource containing step-by-step written and illustrated descriptions of all the important operations in the field of gynecologic oncology.The book contains 1044 pages with more than 300 illustrations and 150 photographs to complement the step by step description of every operative procedure.

New ovarian cancer screening test seems promising
Live Science
A new test to screen for ovarian cancer appears to detect the disease in early stages, and if confirmed in clinical trials, the test could become a routine screening for women.
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Preserved foods linked to ovarian cancer
Food Consumer
A study published in Gynecological Oncology suggests that eating too much of any preserved foods may increase the risk of ovarian cancer. The study led by Andy H. Lee from School of Public Health, Curtin University in Perth, WA, Australia and colleagues show women who had higher intake of preserved foods were 78 percent more likely to develop ovarian cancer, compared with those who had lower intake.
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Study ties poor oral health to cancer-causing virus
The New York Times
People with swollen gums, missing teeth and other signs of poor dental health are more likely to be infected orally with the human papillomavirus, researchers reported. HPV, a sexually transmitted virus, causes cancers of the cervix, mouth and throat. The new study, published in Cancer Prevention Research, is the first to document a link between the infection and poor oral health, but other experts noted that the research found only an association and relied mostly on self-reported data about oral health. It is too early to say with confidence that brushing and flossing regularly can prevent oral HPV infection, they said.
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Minorities most affected by virus that causes cervical, other cancers
New Pittsburgh Couriaer
Each year in the U.S., approximately 12,000 women will be diagnosed with cervical cancer. More than 4,000 women will die from it. Human papillomavirus is responsible for almost all cervical cancers. The virus can also cause cancer of the anus, penis, vagina and throat. Overall, 20 million people in the U.S. have HPV. HPV vaccination may be particularly important for African American and Latino women, as they are hit the hardest. Two Black women die for each White woman who dies from cervical cancer.
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Study compares spectrum of cancer-related gene mutations in two common types of cervical cancer
News Medical
A new study has revealed marked differences in the genomic terrain of the two most common types of cervical cancer, suggesting that patients might benefit from therapies geared to each type's molecular idiosyncrasies. The study, published Aug. 23, in the online version of the journal Cancer by researchers at Dana-Farber Cancer Institute and Brigham and Women's Hospital, is the first to compare the spectrum of cancer-related gene mutations in the two main subtypes of cervical cancer — adenocarcinoma and squamous cell carcinoma. In tests on 80 cervical tumor samples, the investigators found high rates of mutations in two genes: PIK3CA and KRAS. While PIK3CA mutations appeared in both subtypes, KRAS mutations were found only in adenocarcinomas.
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Women's Cancer News
Colby Horton, Vice President of Publishing, 469.420.2601
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