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New Deadline: February 1st
The National Council of the AFMR invites you to apply for the Outstanding Investigator Awards. Recipients will present their work during an oral session at the 2018 Translational Science meeting to be held April 19-21, 2018 in Washington, DC.
Early Registration Deadline: February 15, 2018
February 22-24, 2018
Hotel InterContinental, New Orleans, LA
Discounted Registration Deadline: February 5, 2018
The government has resumed operations following a three day shutdown. Last night, the House and Senate passed a revised “continuing resolution” (CR) to fund the government through February 8, 2018. President Trump signed the legislation allowing all federal agencies are to re-open today.
FASEB Diversity Resources Program has announced the travel award recipients for the APS Professional Skills Training Course held in Orlando, FL, January 11-14, 2018. These awards are meant to promote the entry of students, post doctorates and scientists from underrepresented groups into the mainstream of the basic science community and to encourage the participation of young scientists at the APS Professional Skills Training Course. This year FASEB Diversity Resources Program conferred 9 awards totaling $11,700.
FASEB is now offering regularly recurring webinars on a variety of topics, covering science policy, advocacy, professional development opportunities and more. To attend one or both of the webinars scheduled in January, please click the registration links below. Access the full schedule of upcoming webinars and recordings from past webinars by visiting FASEB’s webinar webpage.
Congress’s inability to pass a long-term spending bill has major ramifications for public health, advocates and former agency officials warn.
The short-term measures hinder efforts to play ahead and recruit staff even as they keep the government open, the advocates say. They have left public health agencies “treading water,” said Ellie Dehoney, vice president of policy and advocacy at Research!America. “It’s just a state of suspended animation.”
Congress is finally (hopefully) about to vote on the 2018 federal budget and in doing so, will determine funding levels for critical medical research infrastructure.
As negotiations play-out, a broad network of stakeholders — some inside the Beltway, and others at key academic centers across the nation — ask with increased urgency: Will medical research get its due? Will promising scientific research be supported at levels that produce breakthroughs? Or will the U.S. pass on opportunities to deliver new therapies and cures and cede leadership to other nations?
Hydration and obesity among outpatient-based population: H2Ob study
Juana Carretero-Gómez, Jose Carlos Arévalo Lorido, Ricardo Gómez Huelgas, Begoña De Escalante Yangüela, Borja Gracia Tello, Luis Pérez Belmonte, Javier Ena Muñoz
Journal of Investigative Medicine Jan 2018, jim-2017-000641; DOI: 10.1136/jim-2017-000641
Receptor signaling and neutral endopeptidase are involved in the resistance of C-type natriuretic peptide to human mesangial proliferation and collagen-IV expression
Huang Huang Luo, Cheng Wu, Peng Hu, Yang Fang Wu, Dong Dong Zhang, Si Yan Liu, Guang Mei Jiang, Yao Xu, Yue Wu, Jing Jing Wang, Fei Fei Liu, Wei Wei, Bo Hu
Journal of Investigative Medicine Jan 2018, jim-2017-000533; DOI: 10.1136/jim-2017-000533
Poverty, a risk factor overlooked: a cross-sectional cohort study comparing poverty rate and cardiovascular disease outcomes in the state of Florida
Bashar Al-Turk, Ciel Harris, Grant Nelson, Carmen Smotherman, Carlos Palacio, Jeff House
Journal of Investigative Medicine Jan 2018, jim-2017-000621; DOI: 10.1136/jim-2017-000621
Survival outcomes of primary cutaneous T-cell lymphoma in HIV-infected patients: a national population-based study
Jianhong Wang, Rong Liang, Caixia Hao, Xiangxiang Liu, Na Zhang, Xiaohui Duan, Hongjuan Dong, Baoxia Dong, HongtaoGu, Guangxun Gao, Tao Zhang, Qingxian Bai, Xiequn Chen
Journal of Investigative Medicine Jan 2018, jim-2017-000636; DOI: 10.1136/jim-2017-000636
Stay informed about JIM and register for e-alerts.
A Case of Myocarditis and Near-Lethal Arrhythmia Associated With Interleukin-2 Therapy
Michael McPhaul, MD,
We present a case of a 48-year-old female who developed myocarditis and near fatal arrhythmias during high dose Il-2 therapy for metastatic renal cancer. On day 5 of therapy, the patient developed sudden onset chest pain, elevated cardiac enzymes and ST segment changes on EKG. Coronary angiogram was normal, however echocardiogram showed reduced ejection fraction and hemodynamic measurements showed elevated bilateral elevated filling pressures. The patient then developed episodes of recurrent ventricular arrhythmia, precipitated by bradycardia and PVC, requiring defibrillation and temporary pacemaker placement. Endomycardial biopsy was nonspecific showing fibrosis with subsequent cardiac MRI showed evidence of myocardial edema, consistent with Il-2 induced myocarditis in the setting of no prior cardiac history. After the discontinuation of Il-2 therapy, the patient displayed clinical improvement as well as improved ejection fraction. This case brings attention to the cardiac toxicities associated with high dose Il-2 therapy including potentially lethal arrhythmias and highlights the importance of careful cardiac screening prior to initiation of treatment.
Oligosecretory Myeloma With Amyloidosis and Alopecia
Amyloidosis is a systemic illness characterized by the extracellular deposition of abnormal proteins in body tissues and organs. In addition to renal involvement, amyloidosis can also present with a variety of skin manifestations, though rarely with alopecia. Sixteen cases of alopecia secondary to systemic amyloidosis are reported. There is one reported case that presented with alopecia universalis. We report a case of a 68-year-old woman presenting with alopecia universalis, rapid decline in kidney function, and nephrotic syndrome who was found to have multiple myeloma-associated AL amyloidosis (immunoglobulin light chain). Her serological workup including serum electrophoresis was negative and she underwent renal biopsy. Pathology revealed eosinophilic material within the mesangium that was Congo-red positive, had apple-green birefringence under polarized light, and ultramicroscopically appeared as fibrillary material. Subsequent bone marrow examination showed a diffuse increase in plasma cells with atypia indicating plasma cell neoplasm. This case underlines several interesting aspects of multiple myeloma and the way it may present with amyloidosis. The lack of monoclonal spike on electrophoresis yet positive light chain analysis deserves special attention by clinicians to avoid a missed diagnosis. The extensive skin involvement also raises several questions regarding the pathologic mechanisms of alopecia in a patient with amyloidosis.
Solving a Mystery . . . 8 Years Later
Erdheim-Chester disease is a rare non-Langerhans cell histiocytosis with multisystem involvement and insidious symptoms. In this article, we describe an interesting case of Erdheim-Chester disease that was eventually diagnosed 8 years after symptoms initially started.
Stay informed about JIM-HICR and register for e-alerts.
By Denise A. Valenti
An adult's brain is going to suffer in the long run if the vascular system is unhealthy. In fact, a recent study found a relationship between blood pressure and the risk of dementia, specific to African-Americans. Another recent study also found that elevation of blood pressure has long-term consequences to the brain, and not just in African-Americans. Together, these studies indicate the need for diligent blood pressure management.
Healthcare IT News
Genome therapy is a part of precision medicine that is slowly going mainstream as policy clarifies reimbursement. The National Institutes of Health, for instance, is working on removing barriers that slow the adoption of genome editing for treating patients.
NIH announced this week the launch of Somatic Cell Genome Editing, a program aimed at picking up the pace in which the technology moves to the clinic for treatment.
A French biopharma company has announced their plans to carry out human trials of a new treatment that would insert genes from light-seeking algae into the eyes of patients with inherited blindness in order to help them regain sight. The treatment involves optogenetics, a technique that converts nerve cells into light sensitive cells.
By Seth Sandronsky
Scientists at the Chinese Academy of Sciences Institute of Neuroscience in Shanghai recently published a paper detailing their cloning of monkeys by somatic cell nuclear transfer (SCNT). The breakthrough research, led by Qiang Sun, raises many questions both in and out of the laboratory. First off, what makes the monkey cloning a breakthrough? After all, Dolly the Sheep was cloned with SCNT back in 1996.
The idea that each of us has a unique nutrition blueprint within our genes is a delicious concept.
Perhaps, this helps explain the growth in personalized nutrition testing and services such as Habit, Profile Precise and Nutrigenomix.
So, what exactly can these tests tell you?
|February 22-24, 2018
||Southern Regional Meeting
||New Orleans, LA
|March 16, 2018
||Eastern Regional Meeting
|April 19-21, 2018
||Translational Science 2018
|April 21-25, 2018
|| Experimental Biology 2018
||San Diego, CA
|April 26-27, 2018
||2018 Combined Annual Meeting of CSCTR & MWAFMR
| || |
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