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|Member Spotlight: New Member Welcome
We are pleased to welcome the newest members of the AFMR!
The 2016 Combined Annual Meeting of the Central Society for Clinical and Translational Research (CSCTR) and the Midwestern Section of the American Federation for Medical Research (MWAFMR), in Chicago, IL was a huge success! This is one of the few multispecialty meetings with a broad focus where the attendees learned research techniques used in other medical specialties and now can apply these techniques to their own research. The Combined Annual Meeting has a rich annual tradition of providing a forum for young investigators, fellows and associate/assistant professors to present their research to leaders in their fields.
The 2016 Eastern Regional Meeting of the American Federation for Medical Research took place Wednesday, April 13, 2016, at the Omni Shoreham in Washington, DC and was a great success!
• Breakfast Workshop: “Relating Mechanisms of Immune Development and Immunological Tolerance to Immune Checkpoint Inhibition in Cancer Treatments”
Chairperson: Iuliana Shapira, MD, SUNY Downstate, Brooklyn NY
Speakers: Susan Gottesman, MD, PhD, SUNY Downstate, Brooklyn NY
Christopher Roman, PhD, SUNY Downstate, Brooklyn NY
Clinical Expert: Janice Dutcher, MD, Cancer Research Foundation, Bronx NY
• 7th Annual Former AFMR President’s Address: “Crossing the Great Divide in Biomedical Research without a Horse”
Robert J. Freishtat, MD, MPH, Children's National Medical Center, Washington DC
• Research!America Advocacy Workshop: "Your Role in Shaping Science Policy through Advocacy"
Anna Briseno, Senior Communications Specialist, Research!America
• Career Development Workshop: “Building a Faculty Development Program from Scratch”
Joseph P. Merlino, MD, MPA, FACPsych, Vice President for Faculty Affairs and Professional Development, Professor of Clinical Psychiatry, SUNY Downstate, Brooklyn NY.
Transition to Independence: Evidence-Based Milestones and Benchmarks Myth Busting
Becoming an independent researcher is a crucial yet poorly understood step for an academic translational scientist. This session aimed to highlight the critical and timely milestones academic researchers should achieve to maximize their chances of becoming independent. Expert senior leaders used real-world data and experience to define the optimal timing, pace, and content of success in the early investigator’s career.
Chairs: Katherine Hartmann, MD, PhD, Vanderbilt University and Michael Schivo, MD, University of California, Davis
Speakers: Katherine Hartmann, MD, PhD, Associate Dean, Clinical and Translational Scientist Development, Director, Graduate Studies in Epidemiology, Professor of Obstetrics & Gynecology and Medicine, Vanderbilt University
Frederick J. Meyers, MD, MACP, Vice Dean, School of Medicine; Professor of Medicine, University of California
Serendipity in Science
This session showcased the pathways and discoveries of accomplished scientists from diverse backgrounds, including the pitfalls and strokes of luck that are keys to all great scientific careers. Serendipity strived to convey how great thinkers learn from their experiences and translate their science to the greater world. The ultimate goal of this session was to inspire beginning and established scientists alike with the speakers' wisdom gained from their careers.
Chairs: Michael Schivo, MD, MAS of the University of California, Davis and MingMing Ning, MD, MmSc of Harvard Medical School
Speakers:Jeremiah Faith, PhD, Assistant Professor of Genetics and Genomic Sciences, Medicine, and Clinical Immunology at Mount Sinai Hospital
Claire Gmachl, PhD, MSc, Director of MIRTHE, Professor of Electrical Engineering at Princeton University
Steve Small, PhD, MD, Stanley van den Noorf Professor and Chair, Professor of Neurobiology and Behavior, Professor of Cognitive Sciences, Director, Brain Imaging Center at University of California, Irving
Innovations in Academic-Industrial Collaborations: Reaching for Pioneering Funding Mechanisms
As research funding becomes increasingly competitive, investigators are seeking newer funding mechanisms. This paradigm is coupled with the need for specialized medical products (e.g., drugs, devices, etc.) to transition out of academia and into the marketplace to enhance personalized and customized medicine. In this session, expert translational scientists with track records of successful academic-industry collaborations were able to discuss the keys to optimizing this vital bridge.
Chair: Michael Schivo, MD, MAS of the University of California, Davis
Speakers: Raed Dwelk, MD, Director, Pulmonary Vascular Program, Respiratory Institute, Professor of Medicine and Pathobiology, Respiratory Institute and Learner Research Institute, the Cleveland Clinic Lerner College of Medicine at Case Western Reserve University
Gary W. Hunter, PhD, Senior Electronics Engineer, Sensors and Electronics Branch, NASA Glenn Research Center
Amar R. Chadaga, Dana Villines, Armand Krikorian
A national cross-sectional survey from a sample of residents and fellows who completed an online bullying survey conducted in June 2015. The survey was distributed using a chain sampling method that relied on electronic referrals from 4,055 training programs, with 1,791 residents and fellows completing the survey in its entirety. Survey respondents completed basic demographic and programmatic information plus four general bullying and 20 specific bullying behavior questions. Between-group differences were compared for demographic and programmatic stratifications. Learn more.
Research!America’s Advocacy Award honorees believe in better. A better life for you and your loved ones. A better way to find solutions to what ails us. Let’s celebrate exemplary leaders in medical, health and scientific research whose advocacy efforts have been notably effective in advancing our nation’s commitment to research. If you know an outstanding advocate whose contributions have brought us closer to cures for deadly and disabling diseases, individuals dedicated to advancing medical progress, nominate them for the 2017 Advocacy Awards!
To be considered for one of our prestigious 2017 Advocacy Awards, submit nominations here. We encourage you to nominate individuals and organizations whose noteworthy accomplishments in advocacy for medical, health and scientific research have saved lives and improved the health of our nation.
All nominations for the 2017 Advocacy Awards are due no later than May 20, 2016.
The awards will be presented on March 15, 2017 at Research!America’s Advocacy Awards Dinner in Washington, DC. The annual Research!America Advocacy Awards Program was established in 1996 by the Board of Directors to honor outstanding advocates for medical, health and scientific research. Visit our website to view the list of past award recipients and recap of the 2016 Advocacy Awards Dinner.
Dear Research Advocate:
In the multi-faceted context of discouraging new data that shows an increasing incidence of suicide, rapidly rising prescription drug abuse, and widespread pain and suffering due to the heroin epidemic, the House is working on legislation to address opioid abuse, approving more than a dozen bills that will be packaged and considered on the floor in early May. This is important bipartisan progress in combating challenges of frightening scope, extending beyond addressing addiction and abuse to effectively meeting the challenge of chronic pain. Even as we commit to working harder to activate what we know works in terms of prevention and treatment, we must learn much more if we are to tamp down this scourge. Research is - and must be - part of the solution to what ails us.
Save-the-Date: Join us at the Western Regional Medical Conference (formerly known as the Western Regional Meeting), January 26-28, 2017 in Carmel California.
Save-the-Date: Join us at the Southern Regional Meeting, February 16-18, 2017 in New Orleans, Louisiana.
AFMR sponsored two successful symposia at Experimental Biology 2016. Next year, Experimental Biology will be held from April 22-26, 2017 in Chicago. Over 14,000 physicians, scientists, and healthcare professionals are expected to attend this very prestigious multidisciplinary scientific meeting. We look forward to seeing you there!
Benefits of membership include:
AFMR programs offer members many opportunities to network with other clinician-scientists within their chosen field. Join today and become a part of the organization devoted to the best interests of you- the modern day medical researcher.
- Subscription to the Journal of Investigative Medicine (JIM)
- Discounted fees to publish in the Journal of Investigative Medicine High Impact Case Reports
- Eligibility to apply for AFMR Foundation awards
- Ability to participate on AFMR councils, committees, and FASEB activities
- Discounted registration rates at AFMR national and regional meetings
As you review your annual giving for the upcoming year, I would like to ask you to consider a gift to the American Federation for Medical Research. Your contribution will be used to support AFMR-sponsored activities and we need your support.
With your generous donation, we can continue to offer innovative programs to help our members advance their careers at government facilities; medical centers; universities and medical schools; research institutions; and private industry in all 50 states and throughout the world. The AFMR provides young and aspiring trainees with scholarships and travel grants to attend regional meetings offering them the opportunity to present their findings to their peers and receive the guidance of senior scientists. The AFMR also recognizes trainees with national awards, such as the Henry Christian awards, named after the founder of the organization, Dr. Henry Christian. The AFMR strives to foster the development of future generations of clinical scientists and investigators through its initiatives, while encouraging public, private, and governmental investment in the development of these individuals.
Contributions are tax-deductible. Whether you choose to contribute $50, $100, $250, or another amount, I urge you to participate. I also welcome your suggestions or ideas about other potential sponsors for our programs. Most importantly, we thank you if you made a donation in 2016.
Please click here if you would like to make an online donation in 2016.
Leticia M. Ryan, MD, MPH
Sleep deprivation is a public health epidemic that causes wide-ranging deleterious consequences, including impaired memory and cognition. Protein synthesis in hippocampal neurons promotes memory and cognition. The kinase complex mammalian target of rapamycin complex 1 stimulates protein synthesis by phosphorylating and inhibiting the eukaryotic translation initiation factor 4E–binding protein 2.
Two new studies report on the potential of a number of antioxidants and a cholesterol-lowering drug to prevent neurodegeneration in a Drosophila genetic model of parkinsonism. This research shines a spotlight on the power of invertebrate models as an in vivo screening tool.
The New England Journal of Medicine
Previous trials have shown that among high-risk patients with aortic stenosis, survival rates are similar with transcatheter aortic-valve replacement and surgical aortic-valve replacement. We evaluated the two procedures in a randomized trial involving intermediate-risk patients.
The New England Journal of Medicine
Ixazomib is an oral proteasome inhibitor that is currently being studied for the treatment of multiple myeloma. In this double-blind, placebo-controlled, phase 3 trial, we randomly assigned 722 patients who had relapsed, refractory, or relapsed and refractory multiple myeloma to receive ixazomib plus lenalidomide–dexamethasone or placebo plus lenalidomide–dexamethasone. The primary end point was progression-free survival.
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