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Next year's Midwestern AFMR Meeting will take place again at the Hilton Chicago Magnificent Mile Suites on April 4-5, 2019. The AFMR gratefully values their collaboration with the CSCTR! At this year's highly successful 2018 Combined Annual Meeting, in conjunction with the AFMR Career Development Workshop, 4 AFMR Scholar Awardees, 1 Henry Christian Awardee and the AFMR Junior Physician Investigator were given the opportunity to showcase their work with oral presentations. Therefore, I invite you to submit your abstracts this fall, apply for AFMR awards, attend the 2019 meeting and get involved in the American Federation for Medical Research! I welcome your input on how we may serve you – please contact the AFMR National Office to provide your ideas.
Vijay Shivaswamy, MBBS, MS
Chair, Midwestern Section Council
Welcome new council members
Chair-Elect, Term: Apr 30, 2019
Joumana T. Chaiban, MD, FACE
UIC/ Advocate Christ Medical Center, Chicago IL
Secretary-Treasurer, Term: Apr 30, 2021
Attaya Suvannasankha, MD
Indiana University School of Medicine, Indianapolis IN
Councilor, Term: Apr 30, 2021
Medical College of Wisconsin, Milwaukee WI
Councilor, Term: Apr 30, 2021
Edgar Lerma, MD
UIC/ Advocate Christ Medical Center, Berwyn IL
On May 17 FASEB submitted comments to the Department of Health and Human Services (HHS) in response to a Notice of Proposed Rulemaking (NPRM) seeking to delay the general compliance date for the revised Federal Policy for the Protection of Human Subjects, i.e., the Common Rule, while allowing implementation of three specific provisions from the revised Rule.
An overwhelming majority of Americans (95%) think infectious and emerging diseases facing other countries will pose a ‘major’ or ‘minor’ threat to the U.S. in the next few years, but more than half (61%) say they are confident the federal government can prevent a major infectious disease outbreak in the U.S., according to a new national public opinion survey(link is external) commissioned by Research!America and the American Society for Microbiology.
FASEB BioAdvances, a new peer-reviewed, open access journal, is accepting author submissions as of June 4, 2018. A partnership of the Federation of American Societies for Experimental Biology (FASEB) and John Wiley and Sons Inc., FASEB BioAdvances will be edited by Jasna Markovac, PhD. Dr. Markovac has an academic appointment at California Institute of Technology and will serve as the publication’s Founding Editor, publishing multi/transdisciplinary research from the international community.
Results of a recent survey examined the thoughts of Americans concerning the potential impact infectious and emerging diseases facing other countries will have in the United States.
The effort, commissioned by Research!America and the American Society for Microbiology, showed 95 percent of Americans believe diseases facing other countries will pose a significant or minor threat here. However, 61 percent are optimistic the government can quell an outbreak.
A Rare Case of Raoultella planticola Urinary Tract Infection in a Patient With Immunoglobulin A Nephropathy
Michael McPhaul, MD,
Raoultella planticola is a gram-negative, aerobic, nonmotile mostly found in environments with high prevalence in soil and water. This organism is a very rare human pathogen as only 29 cases of Raoultella planticola–related infections have been reported until 2017, with only 7 cases in the United States. Only 3 cases of urinary tract infection secondary to R planticola have been reported, 1 in a pediatric patient and 2 in adults. In this article, we present a case of R planticolaurinary tract infection in a 65-year-old male with immunoglobulin A nephropathy. On investigation, the patient was found to be septic and empirical antibiotic was started for gram-negative coverage. The patient showed remarkable improvement and discharged on oral antibiotic for 7 days. R planticola rarely cause infection in humans, with overall good prognosis.
Thyroid Abscess: Challenges in Diagnosis and Management
Thyroid abscess is an uncommon infectious pathology. The thyroid is highly resistant to infection due to high iodine content, capsular encasement, and rich vascularity. Acute suppurative thyroiditis represents <1% of thyroid diseases that could potentially become a life-threatening endocrine emergency. A 48-year-old woman with AIDS presented with 3 days of fever, tender neck swelling, and methicillin-resistant Staphylococcus aureus bacteremia. Apart from leukocytosis, initial laboratory values including thyroid function tests were normal. The initial plain computed tomography scan of the neck and ultrasound scan of the neck were inconclusive as well. By day 4, she worsened, and on repeat computed tomography scan of the neck with contrast, multiloculated abscesses in the thyroid and retro pharynx were seen, which needed emergent drainage. Acute suppurative thyroiditis, a rare disease, occurs in patients with either preexisting disorders of the thyroid or in the immunocompromised. The most common pathogen is Staphylococcus aureus. In our case, we highlight the fact that initial imaging may be negative in the early stages of acute suppurative thyroiditis and lead to an erroneous diagnosis of subacute thyroiditis. There are less than 5 cases of methicillin-resistant Staphylococcus aureus suppurative thyroiditis reported.
A Case of Concurrent Gastric and Pancreatic Plasmacytomas in a Patient with Multiple Myeloma: An Extremely Rare Entity
Multiple myeloma (MM), a plasma cell tumor, is primarily a disease of the bone marrow. Extramedullary plasmacytoma, also a plasma cell tumor, is very rare in the gastrointestinal tract and the pancreas, and only a handful cases have been documented till now. Gastric and pancreatic plasmacytomas are usually seen in elderly patients; however, cases in patients as young as 32 years of age have been reported. Commonly, patients with gastric plasmacytoma present with nonspecific symptoms like epigastric pain, abdominal fullness, anorexia, and weight loss, or serious conditions like massive upper gastrointestinal bleeding and gastric outlet obstruction. Patients with pancreatic plasmacytoma commonly present with obstructive jaundice. In this article, we present the case of a 79-year-old man with a history of MM for 3 years, diagnosed with gastric and pancreatic masses, which turned out to be plasmacytomas. To our knowledge, simultaneous occurrence of gastric and pancreatic plasmacytomas is extremely uncommon with less than 5 cases reported in the
Receptor signaling and neutral endopeptidase are involved in the resistance of C-type natriuretic peptide to human mesangial proliferation and collagen-IV expression
Huang Huang Luo, Cheng Wu, Peng Hu, Yang Fang Wu, Dong Dong Zhang, Si Yan Liu, Guang Mei Jiang, Yao Xu, Yue Wu, Jing Jing Wang, Fei Fei Liu, Wei Wei, Bo Hu
Delayed flow-mediated vasodilation and critical coronary stenosis
Concetta Irace, Salvatore DeRosa, Cesare Tripolino, Giuseppe Ambrosio, Caterina Covello, Ennio Abramo, Claudio Carallo, Annalisa Mongiardo, Carmen Spaccarotella, Daniele Torella, Agostino Gnasso, Ciro Indoli
Intramyocardial block in patients with atrioventricular block
Guoliang Li, Ardan M Saguner, Deniz Akdis, Guy H Fontaine
Vitamin D status in prepubertal children with isolated idiopathic growth hormone deficiency: effect of growth hormone therapy
Rasha Tarif Hamza, Amira I Hamed, Mahmoud T Sallam
HSV infection is associated with gestational hypertension: results from the US National inpatient sample
Lifeng Shi, Yan Wu
Analysis of circulating tumor cells in patients with hepatocellular carcinoma recurrence following liver transplantation
Shaoping Wang, Yujian Zheng, Jun Liu, Feng Huo, Jie Zhou
Dual effects for lovastatin in anaplastic thyroid cancer: the pivotal effect of transketolase (TKT) on lovastatin and tumor proliferation
Chih-Yuan Wang, Hao-Ai Shui, Tien-Chun Chang
Significance of neurexin and neuroligin polymorphisms in regulating risk of Hirschsprung’s disease
Yanhong Li, Hui Liu, Yubin Dong
Stay informed about JIM and register for e-alerts.
|January 24-26, 2019
||Western Medical Research Conference
|February 22-24 2019
||Southern Regional Meeting
||New Orleans, LA
|March 6-8, 2019
||AFMR Eastern Regional Meeting
|April 4-5, 2019
||Midwestern AFMR Meeting with CSCTR
|April 6-10, 2019
On May 16, 2018, NCATS announced new findings from a collaborative study indicating that an identified compound, named metarrestin, can block the spread of pancreatic and other cancers in various animal models. The team, comprised of researchers from NCATS, the National Cancer Institute and Northwestern University, also observed that mice treated with metarrestin had fewer tumors and lived longer than mice that did not receive treatment. The results are published in Science Translational Medicine.
The Associated Press via U.S. News & World Report
Patients with pancreatic cancer that hadn't spread lived substantially longer on a four-drug combo than on a single standard cancer drug, a rare advance for a tough-to-treat disease, researchers reported Monday.
The results indicate the powerful chemotherapy treatment known as folfirinox will likely become standard of care for the minority of patients whose pancreatic cancer is diagnosed early enough to be removed by surgery, experts not involved in the study said.
Disgust is our guardian: Though most of us would rather not feel this unpleasant emotion, it helps us avoid disease and infection, new research suggests.
Long before microscopes revealed unseen germs and parasites, humans developed a system of disgust, with six basic triggers warning us to turn away from harmful pathogens, according to a study published in the journal Philosophical Transactions of the Royal Society.
Attention deficit hyperactivity disorder (ADHD) is a mental health condition affecting a huge number of children, adolescents and sometimes adults. The patients exhibit the symptoms of hyperactivity, inattention and impulsivity.
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