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The American Federation for Medical Research (AFMR) would like to extend our thanks to MultiBriefs for collaborating with us over the past three years to bring you a weekly edition of AFMR Insights. Moving forward, we will be altering the format and frequency of this newsletter. Please be on the lookout for a survey this summer, as we want AFMR Insights to be relevant to your professional interests.
The AFMR has a 78-year old history, with the mission to “develop and mentor tomorrow’s leaders in medical research”. The multi-disciplinary nature of the AFMR provides a platform for junior faculty to tap into the professional network of colleagues in other academic medical centers during our four regional meetings, as well as participation at national meetings including Translational Science and Experimental Biology. AFMR also offers roles for members on both regional and national committees, affording you the opportunity to learn leadership skills, plan meetings/symposia, network with other leaders in biomedical research, and develop key partnerships.
AFMR publications reflect our organization’s commitment to enhance the training and career development of the medical research community. The Journal of Investigative Medicine (JIM) is a valuable resource to disseminate your research and review papers, and in 2017 achieved an Impact Factor of 2.029. The Journal of Investigative Medicine: High Impact Case Reports (JIM-HICR), an open access journal, is a growing forum to publish unique and unusual cases. Members and non-members alike have contributed some of their best work to our journals.
I look forward to serving as the Chair of the AFMR Publications Committee for the next three years and ensuring that all AFMR media forms offer you value!
Amir A. Zeki, MD, MAS
AFMR Publications Committee Chair
On June 4, at a reception in his honor, Howard Garrison, PhD, was presented with the FASEB Public Service Award. Garrison, pictured on the left with FASEB President Thomas O. Baldwin, PhD, will retire from FASEB on June 29 after 25 years of distinguished service.
The FASEB Public Service Award recognizes individuals who have made significant contributions to biological and medical research through their work in government, public affairs, journalism, science policy, or related fields. Previous recipients include National Institutes of Health (NIH) Directors Dr. Francis Collins and Dr. James A. Shannon; former Deputy Directors Dr. Ruth L. Kirschstein and Dr. Raynard S. Kington; Senators Arlen Specter and Tom Harkin; and Representatives John Porter, David Obey, and Michael Castle.
A new study published online in The FASEB Journal pinpoints several gender-specific differences in intestinal environment that could be significant for both intestinal and non-intestinal disorders in which the intestinal lining or microbiome have been altered.
A person's gender can play a major role in the risk of certain diseases, including intestinal disorders like irritable bowel syndrome, ulcerative colitis, and celiac disease. Other key factors in such diseases are the intestinal barrier and microbiota, which ideally safeguard a person from potentially harmful agents.
Regarding the article "Guests at ‘hotel influenza’ will help test flu shot" (June 6)(link is external):
The "hotel influenza" study could significantly advance research into the development of a universal flu vaccine and improve the effectiveness of vaccines.
The question is whether Americans recognize the value of vaccines in keeping diseases at bay. More than half of respondents (53 percent) in a survey commissioned by Research!America and the American Society for Microbiology say they did not get the flu vaccine during the last flu season. Among those who said no, 48 percent said they do not trust the flu vaccine, 40 percent said they do not feel they need it to prevent the flu and 26 percent said the flu vaccine is not effective and therefore not worth getting.
Leaders of the scientific community have criticized the myopic actions of this administration to stifle the voice and input of scientific knowledge. For example, President Trump has yet to nominate a scientific advisor. His administration’s budgets have proposed slashing support for scientific research, although Congress has provided increases for many key science agencies such as NIH and the Department of Energy’s Office of Science.
Yet while our community is alarmed by the current state of affairs, we must also recognize a critical long-term need: to encourage and train more scientists to engage in policy, civil engagement, and advocacy. As a community, we may give lip service to the importance of this in public, but we rarely provide any meaningful incentives for scientists to become “civic scientists.” When scientists meaningfully engage the public and policy-makers, we all win. We must find a way to inspire the next generation to step forward and contribute scientific rigor to policy-making and the public debate.
On June 11, FASEB submitted comments in response to a Request for Information (RFI) from the National Institutes of Health, United States Department of Agriculture, and the U.S. Food and Drug Administration seeking input on reducing regulatory burden with respect to animal research. The RFI was in response to the 21st Century Cures Act requirement that these agencies “complete a review of applicable regulations and policies for the care and use of laboratory animals and make revisions, as appropriate, to reduce administrative burden on investigators while maintaining the integrity and credibility of research findings and protection of research animals.”
Evaluation of liver test abnormalities in a patient-centered medical home: do liver test patterns matter?
Andrew D Schreiner, William P Moran, Jingwen Zhang, Elizabeth B Kirkland, Marc E Heincelman, Samuel O Schumann III, Patrick D Mauldin, Don C Rockey
Children with allergic diseases have an increased subsequent risk of migraine upon reaching school age
Chang-Ching Wei, Cheng-Li Lin, Te-Chun Shen, An-Chyi Chen
Survival in B-cell primary ocular lymphoma 1997–2014: a population-based study
Deliang L Liu, Zhuojun J Zheng
The impact of low-dose glucocorticoids on disease activity, bone mineral density, fragility fractures, and 10-year probability of fractures in patients with rheumatoid arthritis
Tien-Tsai Cheng, Han-Ming Lai, Shan-Fu Yu, Wen-Chan Chiu, Chung-Yuan Hsu, Jia-Feng Chen, Ying-Chou Chen
Risk of dementia after charcoal-burning suicide attempts: a nationwide cohort study in Taiwan
Shan-Yueh Chang, Wu-Chien Chien, Chi-Hsiang Chung, Hsin-An Chang, Yu-Chen Kao, Hui-Wen Yeh, Yu-Ching Chou, Chung-Kan Peng, Chih-Hao Shen, Nian-Sheng Tzeng
Pilot study on the occurrence of multiple cancers following cancer-related therapy at the University of Florida, Jacksonville (2011–2016)
Karan Seegobin, Estela Staggs, Robina Khawaja, Satish Maharaj, Shiva Gautam, Carmen Smotherman, Fauzia Rana
Recombinant tissue plasminogen activator treatment of pulmonary embolism also improves deep venous thrombosis
Stay informed about JIM and register for e-alerts.
Endoscopic Retrograde Cholangiopancreatography–Induced Splenic Injury in a Patient With Sleeve Gastrectomy
Michael McPhaul, MD,
Endoscopic retrograde cholangiopancreatography (ERCP) is an invasive procedure with significant complications. Splenic hematoma is an extremely rare but known complication following ERCP that has been increasingly reported in the past several years. We report the case of a 44-year-old patient with a history of sleeve gastrectomy who underwent an ERCP that was complicated by both acute pancreatitis and splenic hematoma. She was managed conservatively under close monitoring in the intensive care unit. Clinicians should be aware of this potentially life-threatening complication to make a prompt diagnosis and begin early appropriate management.
An Unusual Cause of Failure to Ventilate
We report an unusual case of endotracheal tube failure. It was due to a manufacturing defect in the internal white plastic piece that is normally depressed by the luer-lock syringe within the blue pilot balloon. Prior to use, the endotracheal tube was tested and functioned normally. A 64-year-old patient in the intensive care unit with a history of hypertension was being mechanically ventilated after uneventful abdominal surgery. After several hours in the intensive care unit, he was noted to be suddenly no longer receiving adequate tidal volumes from the ventilator. It was found that the cuff on the endotracheal tube was not retaining air when it was filled with air from a syringe. This lead to a large “leak” around the endotracheal tube such that the intended tidal volumes set on the ventilator were not delivered to the patient. The patient was uneventfully reintubated and did well. Subsequent investigation revealed the cause to be a manufacturing defect in the internal white plastic piece that is normally depressed by the luer-lock syringe within the blue pilot balloon. Other mechanisms of cuff failure are reviewed in this case report. This case is an unusual reason for cuff failure. Illustrations supplied alert the reader how to identify the appearance of this manufacturing defect in a pilot balloon. This case illustrates the potential device malfunctions that can develop during a procedure, even when the equipment has been tested and previously functioned well. Even small defects developing in well-engineered products can lead to critical patient care emergencies.
|January 24-26, 2019
||Western Medical Research Conference
|February 21-23 2019
||Southern Regional Meeting
||New Orleans, LA
|March 6-8, 2019
||AFMR Eastern Regional Meeting
|April 4-5, 2019
||Midwestern AFMR Meeting with CSCTR
|April 6-10, 2019
The Food and Drug Administration on Monday approved the country’s first drug derived from marijuana, a medication that treats two rare and devastating forms of epilepsy.
The drug, GW Pharmaceuticals’ Epidiolex, is made of cannabidiol, or CBD, a component of marijuana that does not give users a high. It is given as an oil, and in clinical trials, it was shown to reduce the number of seizures by about 40 percent in patients with Dravet or Lennox-Gastaut syndromes.
A genetically modified poliovirus may help some patients fight a deadly form of brain cancer, researchers report.
The experimental treatment seems to have extended survival in a small group of patients with glioblastoma who faced a grim prognosis because standard treatments had failed, Duke University researchers say.
Flight attendants may have a higher risk of a number of cancers, a new study finds.
Researchers found that women and men on U.S. cabin crews have higher rates of many types of cancer, compared with the general population. This includes cancers of the breast, cervix, skin, thyroid and uterus, as well as gastrointestinal system cancers, which include colon, stomach, esophageal, liver and pancreatic cancers.
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Amir A. Zeki, MD, AFMR Chair, Publishing Committee, 978-927-8330 | www.afmr.org
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