This message was sent to ##Email##
In this new section of Insights, we ask you to please provide your thoughts on a current topic. Results will be shared next week!
Taxing soda and sugary drinks, what’s your position?
NEW TIME & VENUE
March 16, 2018
Wyndham Historic District Hotel
Call for Symposia: Deadline October 22, 2017
Abstract Submission: Opens October 10, 2017
The Pershing Square Sohn Cancer Research Alliance (PSSCRA) today announced the opening of applications for its 2018 Prize for Young Investigators in Cancer Research. The prize of $200,000 per year for up to three years is awarded annually to at least six New York City-based scientists, enabling them to continue to pursue explorative, high-risk/high-reward cancer research at a stage when traditional funding is lacking.
Doris Duke Charitable Foundation
Pre-proposal applications are being sought from physician scientists at the assistant professor level conducting clinical research in any disease area. The Clinical Scientist Development Award does not require institutional nomination. This competition employs a two-stage process. Pre-proposal applications will be reviewed and up to 50 applicants will be invited to submit a full proposal. In keeping with the wishes expressed in Doris Duke's will, experiments that use animals or primary tissues derived from animals will not be supported by this program.
A new report from FASEB, “Maximizing Shared Research Resources,” identifies the challenges encountered by shared research resources providers and users, and makes recommendations for improvement. Shared research resources – from core facilities to living collections and national laboratories – make efficient use of funds and broaden researchers’ access to advanced technologies and materials. But shared resource providers face difficulties that limit their ability to offer cutting-edge services.
The American Physiological Society (APS) has allocated $100,000 for a Hurricane Relief Fund to assist young APS member-researchers in their rebuilding efforts following Hurricanes Harvey, Irma and Maria. Applications are now being accepted for grants of up to $2,000 which are intended to help graduate students and postdoctoral fellowsimpacted by the storms to replace belongings, pay for relocation costs and get back on their feet. Funds do not have to be used toward research-related expenses.
As the opioid epidemic continues to intensify, innovative scientific solutions provide much needed hope to alleviate the suffering of the tens of thousands of Americans. During the webinar, experts will discuss the role of research, implications for public health and the role of pharmacists in addressing the crisis, with time for Q&A.
Friday, October 13, 2017
2:00–3:00 p.m. ET
Lack of trust has become less of a barrier to clinical trial participation, though more work needs to be done as information access and service levels receive low marks in a recent survey. Former US Food and Drug Administration (FDA) Commissioner Robert Califf dubbed 2016 “the year of diversity in clinical trials.” This year, Research!America and the Association of Clinical Research Organizations (ACRO) polled African-Americans, Hispanics, Asians, and non-Hispanic whites on the various barriers to clinical trial participation. The survey was conducted by Zogby Analytics.
As the opioid epidemic has reached a crisis in the U.S., health care providers have been weighing in on strategies for reversing the epidemic. Lucinda L. Maine, PhD, RPh, executive vice president of the American Association of Colleges of Pharmacy, thinks pharmacists can play a larger role in helping to end the growing opioid addiction problem.
Utility of DXA screening for diagnosis of osteoporosis in US veterans aged 70 years and older
Joanna Khatib, Kim Stote, Aidar R Gosmanov
Journal of Investigative Medicine Oct 2017, jim-2017-000557; DOI: 10.1136/jim-2017-000557
Tumor histopathological response to neoadjuvant chemotherapy in childhood solid malignancies: is it still impressive?
Ehab Hanafy, Abdullah Al Jabri, Gelan Gadelkarim, Abdulaziz Dasaq, Faisal Nazim, Mohammed Al Pakrah
Journal of Investigative Medicine Sep 2017, jim-2017-000531; DOI: 10.1136/jim-2017-000531
Prevalence and predictors of US medical graduates’ federal F32, mentored-K, and R01 awards: a national cohort study
Donna B Jeffe, Dorothy A Andriole
Journal of Investigative Medicine Sep 2017, jim-2017-000515; DOI: 10.1136/jim-2017-000515
Stay informed about JIM-HICR and register for e-alerts.
Eosinophilic Enteritis: A Delayed Diagnosis
Michael McPhaul, MD
Eosinophilic gastrointestinal disorders are a rare and complex group of disorders that are characterized by eosinophilic infiltration of the gastrointestinal tract. Patients often present with a wide range of signs and symptoms as any length or layer of the GI tract can be involved such as mucosal, muscular, or serosal. As a part of the workup, patients frequently undergo computed tomography scans and multiple endoscopies before the diagnosis is finally made as was true in our case of a 59-year-old male patient presenting with 2 months of nausea, abdominal pain, and weight loss. He underwent esophagogastroduodenoscopies, colonoscopies, video capsule study, and balloon enteroscopy before the diagnosis was confirmed histologically. Endoscopic and radiographic findings can be variable and are usually unpredictable. The diagnosis is confirmed on histopathological examination of biopsies that must show >15-50 eosinophils/high-power field based on the location in the GI tract. In our patient, erythema, scalloping, whitish exudate, and patches of villous blunting were noted in the duodenum to proximal ileum endoscopically with >50 eosinophils/high-power field confirming the diagnosis of eosinophilic enteritis. This class of diseases is often found in patients with a history of allergic disorders suggestive of hypersensitivity in the etiology of the disease although our patient had no such known history. Elimination diets and steroids are the mainstay of therapy and often lead to complete resolution of symptoms as well as endoscopic and radiographic findings in up to 90% of patients as was seen in our patient, although some patients have a chronic remitting course.
A Diagnostic Surprise: Primary Hodgkin’s Lymphoma of the Lung
An 81-year-old male presented to the emergency room with a 3-month history of progressive shortness of breath, productive cough with white sputum, and generalized weakness with 10-pound weight loss in 2 months. On presentation, the patient was afebrile, with blood pressure of 93/55 mm Hg and oxy-hemoglobin saturation of 92% on 2 liters of oxygen via nasal cannula. Complete blood count with differential was significant for white count of 12 400/mL. Brain natriuretic peptide level was 454 ng/mL. Postero-anterior chest radiograph showed multiple round opacities in the lung fields. Computed tomography scan of the chest confirmed multiple round densities in both the lung fields along with mild mediastinal lymphadenopathy. Core needle biopsy was performed. Immunohistochemical stains were positive for CD30 and CD15 in a population of large atypical cells amid a background of CD3-positive nonneoplastic cells. These results were in support of the diagnosis of classical Hodgkin’s lymphoma of the lung with histological appearance confirming nodular sclerosis type. The patient was started on chemotherapy but was readmitted in 20 days for acute respiratory distress and suffered cardiac arrest and subsequently died. This case highlights the fact that although primary pulmonary Hodgkin’s lymphoma of the lung is a rare entity, it should be thought of as a differential while evaluating lung masses. In these cases, definite diagnosis can only be made by biopsy and histology. Early commencement of chemotherapy and regular follow-up with oncology is essential.
Chronic Lymphocytic Leukemia: A Rare Cause of Pathological Fracture of the Femur
The incidence rate of chronic lymphocytic leukemia (CLL) in the United States is approximately 0.005%; men are at slightly higher risk than women. Bony involvement or pathological fracture rarely occurs in CLL, and it may be the initial presentation. An 85-year-old woman presented with acute respiratory failure secondary to pneumonia. Symptomatology included dyspnea. She was found to have pathological fracture of the femur caused by CLL. The diagnosis of CLL had been made 6 years previously, but the patient had refused therapy. On admission, the patient required endotracheal intubation, mechanical ventilation, and admission to the medical intensive care unit. Endotracheal intubation extubation was successful after 48 hours. The patient then complained of severe left knee pain. Bone radiograph and femoral computed tomography scan revealed acute pathological fracture of the left distal femur. There was no history of trauma. The fracture was stabilized with extension lock splint. Pathological fracture in patients with CLL is associated with hypercalcemia, Richter’s transformation, or multiple myeloma. This patient exemplifies the fact that pathological fracture can be caused by CLL in the absence of hypercalcemia, Richter’s transformation, or multiple myeloma and can be the initial presentation of CLL.
Stay informed about JIM-HICR and register for e-alerts.
Oregon State University via ScienceDaily
Research-funding agencies that require scientists to declare at the proposal stage how their projects will be "transformative" may actually be hindering discovery, according to a study by Oregon State University ecologists.
The requirement can result in decreased funding for the "incremental" research that often paves the way for paradigm-shifting breakthroughs, the OSU scientists assert.
By Dorothy L. Tengler
According to the CDC, insufficient sleep is a public health problem, often leading to traffic accidents and occupational errors. A plethora of information exists about sleep disorders, sleep deprivation and what we can do to improve our sleeping habits, such as going to bed at the same time each night and rising at the same time each morning as well as avoiding large meals, caffeine and nicotine close to bedtime. However, understanding sleep is somewhat complex.
With antimicrobial resistance becoming a real threat in routine surgery, it is salutary to contemplate the early Victorian operating theatre. Pain and death were the norm, the surgical brutality matched by the torments of post-operative infection and putrefaction. In The Butchering Art, medical historian Lindsey Fitzharris ushers us into that realm.
By Denise A. Valenti
Many adults are at greater risk of developing Alzheimer's disease because of their family and genetic history. While one cannot change the genes and risks associated with them, it is possible to mitigate or slow the symptoms of Alzheimer's disease. Knowing what the risks are can be of benefit in the development of target prevention. This just got easier. A research team recently reported that a collection of genes can better predict who will develop Alzheimer’s disease.
A new study by researchers at the University at Buffalo provides a groundbreaking look at how advance care planning medical orders inform emergency medical service (EMS) providers' experiences involving people with intellectual disabilities. Most states in the U.S. have programs that allow terminally ill patients to document their end-of-life decisions. In New York, the Medical Orders for Life-Sustaining Treatment form (MOLST) allows individuals to document what measures healthcare providers, including EMS providers, should take near the end of a patient's life.
|January 25-27, 2018
||Western Medical Research Conference
|February 22-24, 2018
||Southern Regional Meeting
||New Orleans, LA
|March 16, 2018
||Eastern Regional Meeting
|April 19-21, 2018
||Translational Science 2018
|April 21-25, 2018
|| Experimental Biology 2018
||San Diego, CA
|April 26-27, 2018
||2018 Combined Annual Meeting of CSCTR & MWAFMR
| || |
Connect with AFMR
Recent Issues | Subscribe | Unsubscribe | Advertise | Web Version
Colby Horton, Vice President of Publishing, 469-420-2601 | Download media kit
Natalie Thomas, Assistant Executive Editor, 469-420-2635 | Contribute news
MingMing Ning, AFMR Chair, Publishing Committee, 978-927-8330 | www.afmr.org
Elissa Klein, AFMR Executive Director, 978-927-8330 | www.afmr.org
American Federation for Medical Research
500 Cummings Center, Suite 4400 | Beverly, MA 01915 | 978-927-8330 | Contact Us
Learn how to add us to your safe sender list so our emails get to your inbox.
7701 Las Colinas Ridge, Ste. 800, Irving, TX 75063