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A new report, “Reforming Animal Regulations: Workshop Recommendations to Reduce Regulatory Burden,” proposes changes to federal regulations, policies, and guidelines governing the use of animals in research. Report recommendations are a product of collaborative efforts among FASEB, the Association of American Medical Colleges (AAMC), and the Council on Governmental Relations (COGR), with support from the National Association for Biomedical Research (NABR).
Developed using feedback and insight gathered at an April 2017 workshop convened by FASEB, AAMC and COGR, with support from NABR, recommendations are directed to federal agencies involved in the oversight of federally funded animal research. Primary targeting the U.S. National Institutes of Health and the U.S. Department of Agriculture, the report aims to address the numerous conflicting, outdated, or ineffective regulations that do not improve animal welfare.
On October 11, FASEB hosted a webinar on the new “Value of Federally Funded Biological Research” slide deck, along with tips on effective presentation. The slides are designed for both scientific and non-technical audiences and can be used at district meetings, scientific talks, and public outreach events. Watch the webinar below to learn how to effectively communicate the many ways research benefits all Americans, whether you are speaking with members of Congress, the public, or other scientists.
The opioid epidemic is the most important health issue in West Virginia, above obesity, cancer, chronic obstructive pulmonary disease (COPD) and dental disease, according to a state-based public opinion survey commissioned by Research!America. A strong majority of West Virginians (84%) say prescription pain medication abuse and addiction is a major problem in their community, and more than two-thirds (71%) say they know someone who experienced pain so severe they sought prescription medicines to treat it.
Today, President Trump declared the opioid epidemic a national public health emergency. This declaration will help expand access to treatment for patients in rural communities and give states flexibility in using federal grant funds to target those with opioid addictions. This is a positive step, but it doesn’t measure up to the level of commitment needed to combat a scourge that has taken a heavy toll on Americans across the country. Without additional funding to defeat this health threat, addiction in America will not turn the corner. The epidemic is deeply rooted in many communities as opioid-related deaths continue to rise and treatment facilities fill to capacity.
Plasma s-Klotho is related to kidney function and predicts adverse renal outcomes in patients with advanced chronic kidney disease
Qi-feng LIU, Jian-ming YE, Li-xia YU, Ao-lin HE, Qiang SUN, Da-wei HE, Sha-sha LI
Journal of Investigative Medicine Oct 2017, jim-2017-000560;
Reply to ‘Effects of sodium-glucose cotransporter 2 inhibitors on urinary excretion of intact and total angiotensinogen in patients with type 2 diabetes’ by Yoshimoto et al.
David León Jiménez, Ramón Pérez Temprano, Rocío Ruiz Hueso, José Manuel Lopéz Chozas, José Pablo Miramontes González
Journal of Investigative Medicine Oct 2017, jim-2017-000569;
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Rare Case of Duodenal Metastasis From Pulmonary Squamous Cell Carcinoma
Michael McPhaul, MD
Pulmonary squamous cell carcinoma is the second most common non–small cell malignancy of the lung. It commonly metastasizes to the adrenal glands, bone, liver, brain, and kidneys. Most occurrences of metastatic squamous cell carcinoma involving the gastrointestinal tract originate from primary lung tumors. Metastasis to the duodenum, however, is exceedingly rare, with very few cases of stomach or duodenal involvement described in the literature. We report the case of a patient with stage IV pulmonary squamous cell carcinoma metastasizing to the duodenum with an uncommon presentation to add to the paucity of literature available regarding this rare finding. READ MORE
First Necrotizing Fasciitis Caused by Haemophilus influenza Serotype a
Necrotizing fasciitis (NF) is an infrequently encountered skin infection that has high morbidity and mortality, even with prompt medical and surgical intervention. We describe the case of a 67-year-old male presenting with significant NF in his left lower extremity, despite aggressive surgical intervention, and included multiple surgical debridements, ACell Matrix, split-thickness, and negative wound VAC therapy. Ultimately, this patient required a below the knee amputation. This is the first documented case of Haemophilus influenza type a causing NF. < ahref="http://journals.sagepub.com/doi/full/10.1177/2324709617736791">READ MORE
Scleroderma Renal Crisis in Mixed Connective Tissue Disease With Full Renal Recovery Within 3 Months: A Case Report With Expanding Treatment Modalities to Treat Each Clinical Sign as an Independent Entity
Mixed connective tissue disease (MCTD) is a rheumatologic overlap syndrome that can present with symptoms of systemic lupus erythematous, scleroderma, and polymyositis. A severe but rare complication that can occur in MCTD is scleroderma renal crisis. With multiple poor prognostic indicators, the renal outcome is usually poor. The clinical and histological picture is one of a thrombotic microangiopathy. Clinical suspicion has to be high for additional thrombotic or autoimmune processes coexisting due to associated morbidity. In this article, we report a rare case of scleroderma renal crisis in a patient with MCTD who we treated with plasma exchange for clinical suspicion for an underlying thrombotic thrombocytopenia and mycophenolate mofetil for MCTD. The patient had multiple poor prognostic indicators yet made a full renal recovery in less than 3 months. READ MORE
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U.S. Food & Drug Administration
The U.S. Food and Drug Administration today approved the FreeStyle Libre Flash Glucose Monitoring System, the first continuous glucose monitoring system that can be used by adult patients to make diabetes treatment decisions without calibration using a blood sample from the fingertip (often referred to as a “fingerstick”).
Annals of Internal Medicine
A common belief is that one quarter to one third of all diabetes cases remain undiagnosed. However, such prevalence estimates may be overstated by epidemiologic studies that do not use confirmatory testing, as recommended by clinical diagnostic criteria.
The New England Journal of Medicine
Patients with chronic obstructive pulmonary disease (COPD) with an eosinophilic phenotype may benefit from treatment with mepolizumab, a monoclonal antibody directed against interleukin-5.
New and emerging tobacco products (NETPs), especially e-cigarettes, have become popular and their use has increased dramatically, particularly among the younger population by attracting both former tobacco smokers and never smokers. This trend is supported by a common assumption that e-cigarette use is harmless and a safe alternative to cigarette smoking. Despite a lack of sufficient health science evidence, e-cigarettes are promoted as cigarette smoking cessation aids in some health care practices. In short, little is known about the potential adverse health effects of e-cigarette use on the lungs.
Frontiers in Human Neuroscience
Traumatic brain injury (TBI) is a significant public health concern in military and civilian populations (Chiu and LaPorte, 1993). The estimated number of TBI cases occurring each year is 10 million globally and 1.7–3.8 million in the United States alone. 75–90% of those are defined as mild TBI (mTBI) (Selassie et al., 2013; Marin et al., 2014).
Kaiser Health News via NPR
When Annie Dennison was diagnosed with breast cancer last year, she readily followed advice from her medical team, agreeing to harsh treatments in the hope of curing her disease.
"You're terrified out of your mind" after a diagnosis of cancer, said Dennison, 55, a retired psychologist from Orange County, Calif.
In addition to lumpectomy surgery, chemotherapy and other medications, Dennison underwent six weeks of daily radiation treatments. She agreed to the lengthy radiation regimen, she said, because she had no idea there was another option.
Medical News Today
New research, led by Andrew White — an assistant professor of biomedical sciences at Cornell University's College of Veterinary Medicine in Ithaca, NY — has found that when melanocyte stem cells accumulate a certain number of genetic mutations, they become potential cancer-causing cells.
A group of French scientists is due to meet government officials on Oct. 27 in a bid to resolve a row that has left many of the country’s leading biomedical researchers furious.
Scientists were shocked earlier this month when the government unexpectedly postponed a call for applications to create a new crop of medical-research clusters just days before the closing date, and said that it would slash the budget earmarked for the project.
Analyzing samples from a prospective study, University of California San Diego School of Medicine researchers found that human exposure to glyphosate, a chemical widely found in weed killers, has increased approximately 500 percent since the introduction of genetically modified crops.
"The data compares excretion levels of glyphosate and its metabolite aminomethylphosphonic acid in the human body over a 23-year time span, starting in 1993, just before the introduction of genetically modified crops into the United States," said Paul J. Mills, PhD.
|January 25-27, 2018
||Western Medical Research Conference
|February 22-24, 2018
||Southern Regional Meeting
||New Orleans, LA
|March 16, 2018
||Eastern Regional Meeting
|April 19-21, 2018
||Translational Science 2018
|April 21-25, 2018
|| Experimental Biology 2018
||San Diego, CA
|April 26-27, 2018
||2018 Combined Annual Meeting of CSCTR & MWAFMR
| || |
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