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The latest issue of FASEB’s Horizons in Bioscience publication, “Liquid Biopsies: A New Way to Diagnose, Understand & Track Cancer,” has just been released. This two-page resource describes a new technology developed to advance cancer treatment.
FASEB’s Horizons in Bioscience is a series of brief, illustrated articles that describe scientific discoveries on the brink of clinical application. The publication has explored CRISPR/Cas technology, organs-on-a-chip, and epigenetics, among other topics. Printed copies of the articles are available at no cost for educational or advocacy purposes and can be requested by visiting the Breakthroughs & Horizons in Bioscience webpage or by contacting FASEB’s Office of Public Affairs at 301-634-7650.
FASEB President, Tom Baldwin’s article titled “21st Century Investments in Science and Education will Ensure Our Ability to Compete,” was published via online political news publication, The Hill. Throughout the article, Baldwin cites numerous reasons on why now more than ever, the nation must turn its attention to investing resources in science research and education efforts. While, past national initiatives, including sustained funding to major research institutions, such as NIH and NSF, have propelled the U.S. as the leader in scientific innovation, other countries are forging ahead at increasing speed. In fact, Baldwin indicates that America is at a “crossroads,” and in order to continue as a top producer of scientific discovery, exemplified this year with eight of ten Nobel Prizes in science awarded to U.S. researchers, decision makers must consider science funding and resources as a top priority.
Total U.S. investment in medical and health R&D in the U.S. grew by 20.6% from 2013 to 2016 led by industry and the federal government, according to U.S. Investments in Medical and Health Research and Development, a new report from Research!America. Industry continues to invest more than any other sector, accounting for 67.4% of total spending in 2016, followed by the federal government at 21.9%. Federal investments increased from 2013 to 2014 and 2015 to 2016, largely due to increases in the National Institutes of Health (NIH) budget, with a slight decline in NIH and total funding from 2014 to 2015.
Induction of deubiquitinating enzyme USP50 during erythropoiesis and its potential role in the regulation of Ku70 stability
Junting Cai, Jianxin Wei, Valerie Schrott, Jing Zhao, Grant Bullock, Yutong Zhao
Journal of Investigative Medicine Nov 2017, jim-2017-000622; DOI: 10.1136/jim-2017-000622
Tumor histopathological response to neoadjuvant chemotherapy in childhood solid malignancies: is it still impressive?
Ehab Hanafy, Abdullah Al Jabri, Gelan Gadelkarim, Abdulaziz Dasaq, Faisal Nazim, Mohammed Al Pakrah
Journal of Investigative Medicine Nov 2017, jim-2017-000531;
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Inflammatory Breast Cancer and Warm Antibody Autoimmune Hemolytic Anemia: A Rare Paraneoplastic Syndrome
Michael McPhaul, MD,
Autoimmune hemolytic anemia (AIHA) is a disease process that involves the destruction of red blood cells mediated by the humoral immune system. It can be characterized as a cold agglutinin syndrome, paroxysmal cold hemoglobinuria, and warm, mixed type, and drug-induced AIHA. Although a well-established relationship exists between the presence of AIHA and lymphoproliferative malignancy, AIHA rarely presents in association with solid malignancies. An analysis of the limited number of published cases of AIHA in association with solid malignancies performed showed that AIHA may present before the diagnosis of a solid malignancy, concurrently with the presence of a solid malignancy, or even on resolution of a solid malignancy. Few cases of solid cancers associated with AIHA have been reported. AIHA rarely presents as a paraneoplastic syndrome indicating existence of a solid cancer. We report a case of inflammatory breast cancer with AIHA. READ MORE
Gastric Pouch Mixed Adenoneuroendocrine Carcinoma With a Mixed Adenocarcinoma Component After Roux-en-Y Gastric Bypass
The Roux-en-Y gastric bypass is one of the most common procedures currently performed for surgical treatment of patients with severe obesity. Gastric cancer after bariatric surgery is not common, with most of them arising in the excluded stomach. Gastric mixed adenoneuroendocrine carcinomas are a rare type of stomach malignancy, composed of both adenocarcinoma and neuroendocrine tumor-cell components, with the latter comprising at least 30% of the whole neoplasm. In this article, we report a unique case of a mixed adenoneuroendocrine carcinoma with a mixed adenocarcinoma (tubular and poorly cohesive) component arising in the gastric pouch of a patient who underwent previous Roux-en-Y gastric bypass for glycemic control. Since stomach cancer is not usual in patients who have formerly undergone bariatric surgery and symptoms tend to be nonspecific, such diagnosis is often rendered at an advanced stage. Full assessment of these patients when presenting such vague symptoms is critical for an early cancer diagnosis. READ MORE
Use of Phenobarbital in Delirium Tremens
The standard of care for alcohol withdrawal centers on the use of escalating doses of benzodiazepines until clinical improvement is achieved. However, there is no established standard in the care of patients with severe alcohol withdrawal and delirium tremens that is refractory to benzodiazepine therapy. One potential therapy that is gaining traction is the use of phenobarbital, which may be mechanistically superior to benzodiazepines in treating delirium tremens because of its effects on GABA and N-methyl-D-aspartate receptors. The dosing of phenobarbital and its subsequent taper, however, is still unclear and the side effect profile is not well characterized. In this case report, we present the case of a 37-year-old Hispanic male who presented with alcohol withdrawal and subsequent delirium tremens who was treated with phenobarbital with positive clinical response and minimal side effects. READ MORE
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Medical News Today
A recent analysis has found that even 20 years after receiving a diagnosis of estrogen receptor-positive breast cancer, the risk of the cancer's return looms large. Should treatment be extended?
Estrogen receptor-positive (ER-positive) breast cancer is the most common breast cancer type, accounting for around 80 percent of all breast cancer cases.
Have you ever had a restless night's sleep and then in the morning blanked on where you left your keys the night before? Or maybe you've spaced out while driving to work and almost hit a car stopped at a red light?
You're not alone, and for the first time scientists believe they have discovered why this happens.
IUD contraceptive devices may reduce a woman's risk of cervical cancer by about a third, a new review concludes.
Researchers think IUDs might promote an immune response that kills off human papillomavirus (HPV), the virus that causes virtually all cases of cervical cancer.
Falls are the leading cause of injury among older adults and account for $2 billion in direct health-care costs annually ($31 billion in costs to Medicare in the United States in 2012). We aimed to determine which types of fall-prevention programs may be effective for reducing falls in older people.
|January 25-27, 2018
||Western Medical Research Conference
|February 22-24, 2018
||Southern Regional Meeting
||New Orleans, LA
|March 16, 2018
||Eastern Regional Meeting
|April 19-21, 2018
||Translational Science 2018
|April 21-25, 2018
|| Experimental Biology 2018
||San Diego, CA
|April 26-27, 2018
||2018 Combined Annual Meeting of CSCTR & MWAFMR
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