ASCLS eNewsBytes
Dec. 1, 2009

ACOG issues revised cervical cancer screening guidelines
Medscape Medical News
First cervical cancer screening should be at age 21 years, and rescreening can be less frequent than previously recommended, according to newly revised evidence-based guidelines issued by the American College of Obstetricians and Gynecologists. The ACOG's Committee on Practice Bulletins—Gynecology was posted online and will appear in the December printed issue of Obstetrics & Gynecology.More

Primary lung cancer vs. metastatic breast cancer: A probabilistic approach
American Journal of Clinical Pathology via Medscape
One of the most vexing differential diagnoses for pathologists and clinicians is primary lung cancer versus breast cancer metastatic to the lung. When a woman who has been a smoker and who has also had breast cancer has a non–small cell carcinoma in her lung, choosing between lung cancer and breast cancer metastasis is important because treatments for these two tumors differ. The difficulty is due to how lung cancer and breast cancer comprise the two most common fatal malignancies in women, to how tumors from both sites comprise similar appearing cells.More

Blood tests for hallucinations, delusions may be available in future
Medical News Today
Research  in the journal Molecular Psychiatry may reveal the next step to developing an objective clinical laboratory blood tests for psychotic disease stations. Currently, there is no predictive blood test that identifies and prioritizes blood biomarkers for two key psychotic symptoms, one sensory (hallucinations) and one cognitive (delusions). The article provides proof of principle for an approach that may provide a breakthrough for diagnosing and treating diseases such as schizophrenia.More

New HIV infections in decline
Los Angeles Times
The estimated number of new HIV infections each year has declined about 17 percent since 2001, but for every five people infected, only two begin treatment, according to a report from the World Health Organization and UNAIDS. About 2.7 million people were newly infected with the virus that causes AIDS last year, compared with about 3.3 million in 2001 — although direct comparisons are difficult because the numbers are counted differently now.More

FDA approves new flu vaccine
CNN
The U.S. Food and Drug Administration said Friday it has approved a new vaccine to prevent seasonal influenza. Agriflu, made by Novartis Vaccines and Diagnostics, is not intended to protect against the H1N1 virus, commonly known as swine flu. The vaccine was approved using an accelerated approval process, the FDA said.More

Gonadotropin levels influence fertility success
Reuters Health via Medscape
Assisted reproduction is more likely to be successful in women with high basal levels of luteinizing hormone in combination with low basal levels of follicle-stimulating hormone, Swedish researchers report in Human Reproduction.More

Stem cells could offer new source for skin grafts
Scientific American
Researchers are now one step closer to being able to use skin tissue derived from stem cells for the treatment of burn victims, according to a study published in The Lancet. By tweaking the way the cells are grown in a Petri dish, a team of scientists at the Institute for Stem Cell Therapy and Exploration of Monogenic Diseases near Paris, France, was able to coax human embryonic stem cells into becoming multilayered skin tissue.More

S100A1 expression in ovarian and endometrial endometrioid carcinomas is a prognostic indicator of relapse-free survival
the American Society for Clinical Pathology
We sought to investigate the expression levels of S100A1 in ovarian cancer cell lines and tissues to correlate S100A1 with subtype, stage, grade, and relapse-free survival. S100A1 messenger RNA and protein were up-regulated in ovarian cancer cell lines and tumors compared with normal ovarian cell lines and tissues by gene microarray analysis, reverse transcriptase–polymerase chain reaction, quantitative reverse transcriptase–polymerase chain reaction, and Western immunoblotting.More