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FDA approves 1st new tuberculosis drug in 40 years
The Associated Press via Manufacturing.net
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The U.S. Food and Drug Administration approved a Johnson & Johnson tuberculosis drug that is the first new medicine to fight the deadly infection in more than four decades.
The agency approved J&J's pill, Sirturo, for use with older drugs to fight a hard-to-treat strain of tuberculosis that has not responded to other medications. However, the agency cautioned that the drug carries risks of potentially deadly heart problems and should be prescribed carefully by doctors.
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Tool better evaluates validity of genome sequencing
New York University via Laboratory Equipment
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Advances in biotechnologies and computer software have helped make genome sequencing much more common than in the past. But still in question are both the accuracy of different sequencing methods and the best ways to evaluate these efforts. Now, computer scientists have devised a tool to better measure the validity of genome sequencing.
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A clear policy in stem cell therapy will foster innovative health care
Economic Times
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The rising cost of health care has been a cause of concern around the globe. The global economic crisis has seen governments such as the U.S. and Japan attempting to minimize the cost of state-funded health care.
The increased prevalence of cardiovascular disorders, metabolic diseases, cancer, etc., coupled with the emergence of more virulent forms of existing diseases poses a challenge for current medical therapies.
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New microscopy technique lets scientists see live viruses in their natural habitat
Gizmag
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Traditionally, in order to view tiny biological structures such as viruses, they must first be removed from their natural habitats and frozen. While this certainly keeps them still for the microscope, it greatly limits what we can learn about them — it's comparable to an ichthyologist only being able to study dead fish in a lab, instead of observing live ones in the ocean. Now, however, researchers at the Virginia Tech Carilion Research Institute have devised a technique for observing live viruses in a liquid environment. It could have huge implications for the development of treatments for viral infections.
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GBI Labs’s Klear Human Polymer Detection kits can detect human primary antibody on human tissue with no background. It is a biotin-free system. Special blocking buffer and human antibody enhancer are used to provide excellent sensitivity and high specificity. MORE
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New study exposes living cells to synthetic protein
R&D Magazine
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One approach to understanding components in living organisms is to attempt to create them artificially, using principles of chemistry, engineering and genetics. A suite of powerful techniques — referred to as synthetic biology — have been used to produce self-replicating molecules, artificial pathways in living systems and organisms bearing synthetic genomes. In a new twist, researchers have fabricated an artificial protein in the laboratory and examined the surprising ways living cells respond to it.
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New York State licensure update
NSH
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In October 2012, the New York State Education Department began sending notices to individuals with New York State Limited Licenses to remind them of their obligations to complete all licensure requirements by Sept. 1. Limited Licenses will not be valid or renewed after the expiration date nor will this transition pathway be available. It is imperative that these individuals complete all the necessary educational requirements and pass the examination to ensure that they can remain employed in a clinical laboratory in New York State.
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SOX-11 expression is specific for the identification of cyclin D1 negative mantle cell lymphoma. SOX-11 is useful due to its high expression in cyclin D1 positive and negative MCL. Many B-cell lymphomas can mimic MCL; therefore, it’s important to have additional antibodies to detect cyclin D1 negative MCL. Learn More.
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Available in slotted, biopsy and four compartment versions, the Slimsette™ recessed cover allows for use with lids attached during labeling in cassette printers. Part of the full line of cassettes from LabStorage Systems, Slimsette™ comes in convenient dispenser boxes or preloaded in plastic sleeves for automatic printers.
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We’ve added a click and removed the leak. Turn the lid until it clicks. Ship with confidence that your samples and your reputation will stay perfectly preserved. To learn more, please visit us at: www.statlab.com/statclick or contact us at 800-442-3573.
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Could patient-error reports cause pathologists to be responsible for other providers' mistakes?
Dark Daily
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Could clinical pathologists be held responsible for medical errors caused by other providers? That's a possibility under a proposal from the federal Agency for Healthcare Research and Quality.
AHRQ is seeking approval for a prototype of a new reporting system for medical errors, AHRQ Director Dr. Carolyn M. Clancy, told The New York Times in a recent story. "Currently there is no mechanism for consumers to report information about patient safety events," she said.
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The origins of a genetic switch
PhysOrg
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Cilia, microscopic whip-like organelles that protrude from the surface of many cell types, are almost ubiquitous. They are present in all eukaryotes — organisms whose cells have a nucleus — and have diversified to perform a huge variety of functions, from making cells mobile to sensing light. In vertebrates, nearly every cell in the body has some form of cilia. It has now been shown that the development of cilia — in even the most evolutionarily ancient animals — is controlled by the same gene, FoxJ1.
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Stellaris RNA FISH is a new research technology that enables direct detection, localization and quantification of RNA. The low cost per assay, simple protocol, and the ability to localize mRNA and lncRNA to organelles and cellular structures provides obvious benefits for life science research. Custom and catalogued probes sets available. MORE
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Novel strategies for cell-based assays
Genetic Engineering & Biotechnology News
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There are different ways to query cells. Some of these use standard light microscopy observations of dye uptake or morphology, size, adherence or mobility.
Others rely on fluorescence microscopy to track labeled antibodies or reporter-driven GFP expression, or on specialized spectrophotometers to examine enzyme-driven color or light intensity changes in the culture medium. And still others make use of non-optical properties such as heat flow or electrical impedance to detect activity.
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Inducing stem cells to become different cell types efficiently now possible using a 3-D platform
PhysOrg
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Induced pluripotent stem cells have the potential to form any cell type in the body, providing a powerful tool for drug discovery and regenerative medicine. Yet coaxing these cells to reliably take on a specific fate in the laboratory has proven challenging on a large scale. Now, a team of A*STAR stem cell researchers has developed a cell differentiation protocol in which iPS cells are propagated and expanded in a 3-D bioreactor to efficiently create neural progenitor cells.
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New work on Akt's role in cancer stem cell biology
The Medical News
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The protein kinase Akt is a key regulator of cell growth, proliferation, metabolism, survival and death. New work on Akt's role in cancer stem cell biology from the lab of senior author Dr. Honglin Zhou and Weihua Li, co-first author, appears in Molecular Cell. The findings were also highlighted in Nature and Science reviews.
This new research shows that Akt may be the key as to why cancer stem cells are so hard for the body to get rid of.
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Cell biology: Flushing out fats
PhysOrg
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The Wip1 protein is important for survival, but mutations that inactivate it carry some surprising features. "A lack of Wip1 results in an excessive immune reaction to infectious organisms, in some cases killing the host," explains Dmitry Bulavin of the A*STAR Institute of Molecular and Cell Biology, Singapore. He also notes, however, that mice lacking Wip1 are considerably less prone to certain cancers. Now, research from Bulavin and his co-workers has revealed that Wip1-deficient animals also exhibit improved fat metabolism and cardiovascular health.
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Explore our online interactive histology courses, and discover the latest secrets for creating flawless IHC, FISH, special, and routine stains. Complete your annual safety and compliance training hassle free. Document training and get P.A.C.E credits with the included Learning Management System. Get it all with our unlimited annual subscription, available for both individuals and institutions.
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Spring Bioscience is leading the research industry by pioneering novel, next generation antibodies that can differentiate mutant and normal protein, enabling pathologists to see relevant mutations within their cellular context. Having already released Exon19 and EGFR L858R for exclusive use by Ventana Medical Systems, Spring Bioscience has launched BRAF V600E.
Click here to find out more.
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EndNote® enables you to move seamlessly through your research process with flexible tools for searching, organizing and sharing your research, creating your bibliography and writing your paper.
New in X6: Access your research from anywhere and manage your EndNote library from multiple computers with the new EndNoteSync.
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