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NSH NEWS

UFOs (Unfamiliar Objects) on Slides presented by NSH President Elizabeth Sheppard, HT(ASCP)
NSH
On March 26, NSH President Elizabeth Sheppard will be presenting a one-hour webinar regarding Unfamiliar Objects on Slides. She will be discussing three main categories: technical errors in processing, embedding, sectioning and staining; artifacts of diagnostic significance; and miscellaneous artifacts. You will gain the ability to identify unfamiliar objects and learn techniques to avoid them. Register today.
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37th Annual Missouri Spring Symposium — May 9-10
NSH
NSH has partnered with the Missouri Society for Histotechnology to offer an exciting two-day event in America's heartland. The two-day event offers general sessions, workshops and exhibitors for one low price. Attendees have the option to register for a one or two-day pass and techs studying for the HT exam have an opportunity to attend an HT prep course. Join us at the gorgeous Chateau on the Lake in Branson for great education and networking. Learn more.
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Become a sponsor of the 2015 NSH Calendar!
NSH
The NSH Calendar is always a huge hit with membership and now is your chance to become a part of it. Each month offers one advertisement displayed prominently at the bottom of the page. Click here for more information and contact NSH at 443-535-4060 or histo@nsh.org with any additional questions or concerns.
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TOP STORIES


Major breakthrough in developing new cancer drugs: Capturing leukemic stem cells
University of Montreal via Medical Xpress
The Institute for Research in Immunology and Cancer at the Université de Montréal, in collaboration with the Maisonneuve-Rosemont Hospital's Quebec Leukemia Cell Bank, recently achieved a significant breakthrough thanks to the laboratory growth of leukemic stem cells, which will speed up the development of new cancer drugs. In a recent study published in Nature Methods, the scientists involved describe how they succeeded in identifying two new chemical compounds that allow to maintain leukemic stem cells in culture when these are grown outside the body.
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Study finds CT scans predict chemotherapy response in pancreatic cancer
Medical Xpress
Computed tomography scans routinely taken to guide the treatment of pancreatic cancer may provide an important secondary benefit. According to new research from The University of Texas MD Anderson Cancer Center, the scans also reflect how well chemotherapy will penetrate the tumor, predicting the effectiveness of treatment. The research, published in the Journal of Clinical Investigation, is the first human study to address the issue of chemotherapy delivery to pancreatic tumors, a problem previously shown in animal studies.
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Silicone chip recreates cancer's microenvironment
Chemical & Engineering News
Killing cancer cells growing on a petri dish is an entirely different beast than fighting cancer cells in the human body. To provide a more realistic platform for screening anticancer drugs, bioengineers have created a device that better replicates the environment around human tumors than conventional cell culture does. They designed a microfluidic chip that imitates the blood circulation system alongside a three-dimensional tumor. With further development, the chip should be useful for both high-throughput drug screening and for helping doctors quickly pinpoint the best cancer therapy for individual patients.
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Prostate cancer treatment strategies show promise
By Dr. Afsaneh Motamed-Khorasani
As the most predominant cause of cancer-related death for men in the U.S., prostate cancer has been the subject of extensive research that has led to a better understanding of the disease and metastasis mechanism. Since the increased levels of androgen or its signaling activities in males have been shown to be partially responsible for prostate cancer, decreasing the amount of androgens and/or its signaling pathway activity has been attempted. Androgen receptor signaling could be a major player in prostate cancer development and progression.
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Newer radiation therapy treats prostate cancer more quickly
HealthDay News via Philly.com
A newer form of radiation therapy for prostate cancer is faster and less expensive, but it can cause more urinary complications, a new study suggests. The newer therapy delivers a greater dose of radiation per treatment than standard radiation therapy, which means prostate cancer patients can complete an entire course of treatment in one to two weeks instead of seven to nine weeks. There have, however, been few studies comparing the costs and side effects of the two methods.
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Looking for similar articles? Search here, keyword TECHNOLOGY.


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IN THE NEWS


PD-L1 findings in multiple sclerosis could give rise to new treatment options
BioNews Texas
Programmed death-1 ligand is emerging as a player in the complex disease known as multiple sclerosis. Multiple sclerosis, characterized by chronic inflammatory demyelination in the central nervous system, is an autoimmune disease mediated by autoreactive activated T cells. Th1-type inflammatory T cells express the receptor for PD-L1, and when the receptor is blocked from binding with PD-L1, T cells become inhibited. Therefore, as previous studies have shown, PD-L1 is important in inhibiting Th1-type autoimmune diseases, and PD-L1 knockout mice with induced autoimmune diseases show aggravated symptoms. A group from Soochow University in China recently published in Neural Regeneration Research their research on PD-L1 involvement in experimental allergic encephalomyelitis, a mouse model that closely mimics multiple sclerosis in humans.
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Findings reveal potential drug targets for small cell lung cancer
News-Medical.net
Cancer cells undergo extensive genetic alterations as they grow and spread through the body. Some of these mutations, known as "drivers," help spur cells to grow out of control, while others ("passengers") are merely along for the ride. Massachusetts Institute of Technology cancer biologists at the Koch Institute for Integrative Cancer Research and geneticists from the Broad Institute have now performed the most comprehensive analysis to date of these changes in mice programmed to develop cancer. The team discovered mutations and other genetic disturbances that arise at certain stages of lung cancer development; the researchers were also able to identify tumor cells that broke free to spread to other organs.
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Researcher examines immunology in kidneys
University of Virginia via Medical Xpress
University of Virginia undergraduate researcher Kristen Whalen is exploring kidney cells to see if they can protect themselves, which could be a breakthrough in assisting kidneys in surviving injury and the side effects of treatments for diseases elsewhere in the body.
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The challenging market environment for drug companies
By Mike Wokasch
The traditional pharmaceutical industry is going through perhaps its biggest transformation since The Pure Food and Drug Act of 1906. Unfortunately, the entrenched "we have always done it this way" leadership mentality has been slow to react to the magnitude of changes taking place over the past two decades. Every aspect of how drug companies have done business in the past is being re-evaluated, evolved, restructured or even dismantled. More importantly, companies are now realizing they have to come up with new ways to remain viable in this ever-changing market.
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Stem cells possess mechanical memory
Chemical & Engineering News
Human stem cells can remember whether researchers have grown them on a soft bed of polyethylene glycol or on a stiff floor of polystyrene. This mechanical memory in turn influences the fate of these stem cells, such as whether they start differentiating into bone or fat cells. That's one take-home message of a presentation given on March 16 by University of Colorado materials scientist Kristi Anseth at the American Chemical Society meeting in Dallas.
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Nanoflares' catch cancer spread earlier
ACS via Laboratory Equipment
When cancer spreads from one part of the body to another, it becomes even more deadly. It moves with stealth and can go undetected for months or years. But, a new technology that uses "nanoflares" has the potential to catch these lurking, mobilized tumor cells early. Today, scientists presented the latest advances in nanoflare technology as it applies to the detection of metastatic breast cancer cells.
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TRENDING ARTICLES
Missed last week's issue? See which articles your colleagues read most.

    Diagnosing diseases with smartphones (R&D Magazine)
A link between blood and plasma trace metals in Alzheimer's disease? (By Dr. Afsaneh Motamed-Khorasani)
Latest prostate cancer study adds to debate (The Boston Globe)
Fluorescence microscopy aids in melanoma development discovery (BioOptics World)
Histotechnology Professionals Day Scavenger Hunt — March 10-17 (NSH)

Don't be left behind. Click here to see what else you missed.
 

Under the Microscope
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