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 Top Stories

Scientists discover 'missing link' between blood stem cells, immune system
Bioscience Technology    Share    Share on FacebookTwitterShare on LinkedinE-mail article
UCLA researchers have discovered a type of cell that is the "missing link" between bone marrow stem cells and all the cells of the human immune system, a finding that will lead to a greater understanding of how a healthy immune system is produced and how disease can lead to poor immune function. More



FDA issues proposed rule on medical device UDI system that will also apply to clinical pathology analyzers and lab products
Dark Daily    Share    Share on FacebookTwitterShare on LinkedinE-mail article
UPCs — universal product codes — are coming soon to the medical laboratory analyzers and other products that your clinical laboratory purchases. Under a proposed rule published by the Food and Drug Administration, medical devices will soon have UDIs — universal device identifiers. More

Stellaris RNA FISH Probes

Stellaris RNA FISH is a new research technology that enables direct detection, localization and quantification of RNA. The low cost per assay, simple protocol, and the ability to localize mRNA and lncRNA to organelles and cellular structures provides obvious benefits for life science research. Custom and catalogued probes sets available. MORE


EHRs feed clinical research machine
InformationWeek    Share    Share on FacebookTwitterShare on LinkedinE-mail article
A major medical study that used EHR data to comb through the clinical records of nearly 1 million patients shows that advanced technology can have a significant impact on clinical research. The study involved a team of data experts at MetroHealth Medical Center and Explorys Inc., that provides a health data analytics platform. The study tried to find out whether height and/or weight can make a person more susceptible to blood clots in the lung or leg. Using the Explorys tool, which standardized the data and de-identified patient information, researchers analyzed the clinical records of 959,030 patients, pooled from multiple healthcare organizations that use different EHR systems. More


 NSH News


Visit the NSH booth #517 in Vancouver
NSH    Share    Share on FacebookTwitterShare on LinkedinE-mail article
This year the NSH Committee Fair has moved into the Exhibit Hall. Have questions for NSH about something in a specific area of histology? Be sure to stop by booth #517 to get your answers and see what's new. Anyone who stops by will receive a Histotechnology Rubiks Cube. More




 In the News


Study: Statins may stem tumor growth
Medical Xpress    Share    Share on FacebookTwitterShare on LinkedinE-mail article
One of the world's best-selling drugs potentially also acts against the growth of new lymphatic vessels, with potential implications for cancer therapy. This surprising finding was brought forward by Swiss researchers with their newly developed three-dimensional cell culture system. More


New SOX-11 (MRQ-58) for MCL!
SOX-11 expression is specific for the identification of cyclin D1 negative mantle cell lymphoma. SOX-11 is useful due to its high expression in cyclin D1 positive and negative MCL. Many B-cell lymphomas can mimic MCL; therefore, it’s important to have additional antibodies to detect cyclin D1 negative MCL. Learn More.
Human on Human Detection Kits
GBI Labs’s Klear Human Polymer Detection kits can detect human primary antibody on human tissue with no background. It is a biotin-free system. Special blocking buffer and human antibody enhancer are used to provide excellent sensitivity and high specificity. MORE
StatClick™ Specimen Transport Vials
We’ve added a click and removed the leak. Turn the lid until it clicks. Ship with confidence that your samples and your reputation will stay perfectly preserved. To learn more, please visit us at: www.statlab.com/statclick or contact us at 800-442-3573.


Paralyzed patients regain some sensory function after neural stem cell treatment
CBS News    Share    Share on FacebookTwitterShare on LinkedinE-mail article
For most people who are paralyzed, there is no treatment available to help them regain full function of their limbs. But, promising new research from a phase 1 study conducted at the University of Zurich sponsored by StemCells Inc. shows that six months after the implantation of neural stem cells, two out of three complete injury patients — meaning they had no neurological function below the point of injury — were able to gain some sensory function. More

Scientists discover RNA phenomenon that challenges dogma
R&D Magazine    Share    Share on FacebookTwitterShare on LinkedinE-mail article
Some RNA molecules spend time in a restful state akin to hibernation rather than automatically carrying out their established job of delivering protein-building instructions in cells, new research suggests. And instead of being a fluke or a mistake, the research suggests that this restful period appears to be a programmed step for RNA produced by certain types of genes, including some that control cell division and decide where proteins will work in a cell to sustain the cell's life. This could mean that protein production in cells is not as clear-cut as biology textbooks suggest, scientists say. More



Polymer composite stops pathological bone formation
Laboratory Equipment    Share    Share on FacebookTwitterShare on LinkedinE-mail article
A multidisciplinary research team led by Carnegie Mellon University is developing new nanostructural polymer-based treatments to eliminate pathological bone formation in soft tissue, a common occurrence following orthopedic surgeries and amputations. "Our tactic is to develop a solution that will control the pathological growth of bone in muscle and tendons (called heterotopic ossification) that frequently occurs following bone trauma and orthopedic surgery," says Jeffrey Hollinger, professor of biomedical engineering and biological sciences, and head of CMU's Bone Tissue Engineering Center. More


Digital Pathology Tools for Biomarker Research
PerkinElmer offers a range of solutions including streamlined TMA & whole slide scanners, patented multispectral imaging and analysis and automated quantitation of biomarkers in tissue. www.perkinelmer.com/tissueimaging
Abcam

Produce publication quality images and benefit from greater sensitivity, improved signal-to-noise ratio as well as reduced background with Abcam’s EXPOSE IHC biotin-free detection systems. Visit us at Booth 349 at the 2012 Convention. MORE


Deconstructing 3-D cell culture
Bioscience Technology    Share    Share on FacebookTwitterShare on LinkedinE-mail article
3-D culture models offer the potential to significantly reduce drug failure. There is an urgent need to improve the efficiency of drug development. It has been estimated that only 9 percent of drugs that enter clinical development receive market approval. The reason for the failure of drugs is often a poor understanding of the biology behind human disease that leads to a lack of clinical efficacy and drug toxicities, off-target effects or side effects, particularly prominent in liver or heart. 3-D culture models offer the potential to significantly reduce this figure. More

PRISM technique as accurate as ELISAs in identifying proteins within biological samples
News-Medical    Share    Share on FacebookTwitterShare on LinkedinE-mail article
Combining two well-established analytic techniques and adding a twist identifies proteins from blood with as much accuracy and sensitivity as the antibody-based tests used clinically, researchers reported in Proceedings of the National Academy of Sciences Early Edition online. The technique should be able to speed up development of diagnostic tests and treatments based on proteins specific to certain diseases. More

DispoCut™ Disposable Dissecting Boards

Lab Storage Systems is proud to offer the DispoCut™ disposable dissecting board. This dissecting board is strong enough to reuse, yet inexpensive enough to throw away. Conveniently printed on both sides in inches and metric measurements. Available in 3 sizes. MORE


New anticancer agents may lead to greater toxicity, discontinuation rates than standard therapy
Modern Medicine    Share    Share on FacebookTwitterShare on LinkedinE-mail article
New anticancer agents that offer improved efficacy compared with standard therapy also increase morbidity and treatment-related mortality, according to a meta-analysis published in the Journal of Clinical Oncology. Eitan Amir, M.D., of the Division of Medical Oncology, Princess Margaret Hospital, Toronto, and colleagues, identified and analyzed 38 randomized clinical trials evaluating anticancer agents for the treatment of solid tumors between 2000 and 2010. More

Infrared spectroscopy: Analyzing interactions between proteins and pharmaceuticals
Phys.Org    Share    Share on FacebookTwitterShare on LinkedinE-mail article
Ruhr-Universitaet-Bochum researchers have developed a new method for the detailed study of the interaction between pharmaceuticals and their target proteins. The pharmaceutical industry has already taken notice of the new infrared spectroscopy technique; the method is supposed to be implemented to investigate pharmacological agent-protein interactions in the EU project K4DD, which is supported by various major European pharmaceutical companies. More



Mass spectrometry makes the clinical grade
R&D Magazine    Share    Share on FacebookTwitterShare on LinkedinE-mail article
Combining two well-established analytic techniques and adding a twist identifies proteins from blood with as much accuracy and sensitivity as the antibody-based tests used clinically, researchers report in Proceedings of the National Academy of Sciences Early Edition online. The technique should be able to speed up development of diagnostic tests and treatments based on proteins specific to certain diseases. More

Colorado reports 1st case of human plague in 6 years
Examiner.com    Share    Share on FacebookTwitterShare on LinkedinE-mail article
An Archuleta County resident in Colorado is currently being hospitalized in a Denver pediatric ICU for a case of septicemic plague. According to a San Juan Basin Health Department news release, the individual is believed to have contracted the disease while recreating with family northwest of Pagosa Springs in the Cimarrona Campground near Williams Creek Reservoir in the San Juan National Forest; however, the investigation is in progress. Health officials say this is the first confirmed case of human plague in Colorado since 2006. The last human case in Archuleta County was in 1998. More


Spring Bioscience - BRAF V600E

Spring Bioscience is leading the research industry by pioneering novel, next generation antibodies that can differentiate mutant and normal protein, enabling pathologists to see relevant mutations within their cellular context. Having already released Exon19 and EGFR L858R for exclusive use by Ventana Medical Systems, Spring Bioscience has launched BRAF V600E.
Click here to find out more.
Get your histology CE from MediaLab

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RDO RAPID DECALCIFIER
RDO Rapid Decalcifier is a major improvement to histological processing procedures. Compared with other commercially available decalcifiers, RDO gently decalcifies specimens in a fraction of the time.
 

Under the Microscope
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