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New genomics breakthrough shows need for government-funded research
U.S. News & World Report    Share    Share on FacebookTwitterShare on LinkedinE-mail article
Politicians and business leaders debate whether government should invest in advanced scientific research, or leave this investment to the private sector. Opponents of government support cite Solyndra's collapse last year. Proponents cite successful government investment for the Internet and other important technologies. Recently, proponents of government-sponsored research chalked up a major new win: the ENCODE Project, a major decade-long investigation into human genetics. The success of ENCODE underscores two important points: why we need government investment to complete certain kinds of large-scale research, and how such research should be structured so it works. More



Big health care acquisitions make news, change competitive landscape for clinical pathology laboratories
Dark Daily    Share    Share on FacebookTwitterShare on LinkedinE-mail article
Big health care players are spending hundreds of millions of dollars to acquire unexpected targets. The biggest of these deals signal that health care consolidation and integration is a continuing trend. It is also a reminder to clinical laboratory managers and pathologists that the competitive health care marketplace is transforming at a steady pace. More

Tissue engineering: New ears, grown from collagen cells and tested on rats, could help wounded veterans
The Huffington Post    Share    Share on FacebookTwitterShare on LinkedinE-mail article
VideoBriefWhen William Shakespeare penned the line, "Friends, Romans, countrymen, lend me your ears," the famous playwright meant it in the most figurative sense. But it seems researchers at Massachusetts General Hospital have taken it quite literally. Scientists at the Laboratory for Tissue Engineering and Organ Fabrication there, working to develop reconstructive plastic surgery techniques for wounded veterans, have learned how to successfully grow new sets of ears. More

Stellaris RNA FISH Probes

Stellaris RNA FISH is a new research technology that enables direct detection, localization and quantification of RNA. The low cost per assay, simple protocol, and the ability to localize mRNA and lncRNA to organelles and cellular structures provides obvious benefits for life science research. Custom and catalogued probes sets available. MORE



 In the News


UCLA scientists awarded $8.7 million in grants for stem cell research
Examiner.com    Share    Share on FacebookTwitterShare on LinkedinE-mail article
UCLA stem cell researchers are on the cutting edge of developing new technology in their field. Recently, UCLA Health System announced that three researchers had been awarded a total of $8.7 million in basic biology grants from the state stem cell agency. Dr. Stanley Nelson was awarded $6 million; Dr. Owen Witte and Kathrin Plath were awarded more than $2.7 million dollars in two grants. More



Studies: Alzheimer drug may stabilize brain plaque
The Associated Press via Bioscience Technology    Share    Share on FacebookTwitterShare on LinkedinE-mail article
An experimental drug that failed to stop mental decline in Alzheimer's patients also showed some potential benefit, fuller results of two major studies now show. Some patients on the drug had stable levels of brain plaque and less evidence of nerve damage compared to others who were given a dummy treatment, researchers reported. The drug is called bapineuzumab, made by Pfizer Inc. and Johnson & Johnson. The new results suggest it might work if given earlier in the course of the disease, before so much damage and memory loss have occurred that it might not be possible to reverse, experts say. More


New SOX-11 (MRQ-58) for MCL!
SOX-11 expression is specific for the identification of cyclin D1 negative mantle cell lymphoma. SOX-11 is useful due to its high expression in cyclin D1 positive and negative MCL. Many B-cell lymphomas can mimic MCL; therefore, it’s important to have additional antibodies to detect cyclin D1 negative MCL. Learn More.
Human on Human Detection Kits
GBI Labs’s Klear Human Polymer Detection kits can detect human primary antibody on human tissue with no background. It is a biotin-free system. Special blocking buffer and human antibody enhancer are used to provide excellent sensitivity and high specificity. MORE
StatClick™ Specimen Transport Vials
We’ve added a click and removed the leak. Turn the lid until it clicks. Ship with confidence that your samples and your reputation will stay perfectly preserved. To learn more, please visit us at: www.statlab.com/statclick or contact us at 800-442-3573.


Cancer study points to tighter pairing of drugs and patients
The New York Times    Share    Share on FacebookTwitterShare on LinkedinE-mail article
The first large and comprehensive study of the genetics of a common lung cancer has found that more than half the tumors from that cancer have mutations that might be treated by new drugs that are already in the pipeline or that could be easily developed. For the tens of thousands of Americans with that cancer — squamous cell lung cancer — the results are promising because they could foretell a new type of treatment in which drugs are tailored to match the genetic abnormality in each patient, researchers say. More



Research finds heart remodeling rapidly follows cardiac injury
RedOrbit    Share    Share on FacebookTwitterShare on LinkedinE-mail article
Cardiac injury leads to significant structural changes in the heart, including enlargement, excess formation of fibrous growth tissue and abnormalities of the coronary vasculature. While associated factors have been targeted for therapeutic intervention, the results have been conflicting. Most studies have investigated these changes after six days of injury. However, advanced stages of remodeling have already begun by day seven following injury. New research reveals that morphological changes in response to cardiac injury occur rapidly, with implications for the development of therapeutic strategies. The results are published in the October issue of The American Journal of Pathology. More

Ancient enzymes function like nanopistons to unwind RNA
R&D Magazine    Share    Share on FacebookTwitterShare on LinkedinE-mail article
Molecular biologists at The University of Texas at Austin have solved one of the mysteries of how double-stranded RNA is remodeled inside cells in both their normal and disease states. The discovery may have implications for treating cancer and viruses in humans. The research, which was published in Nature, found that DEAD-box proteins, which are ancient enzymes found in all forms of life, function as recycling "nanopistons." They use chemical energy to clamp down and pry open RNA strands, thereby enabling the formation of new structures. More


Digital Pathology Tools for Biomarker Research
PerkinElmer offers a range of solutions including streamlined TMA & whole slide scanners, patented multispectral imaging and analysis and automated quantitation of biomarkers in tissue. www.perkinelmer.com/tissueimaging
Abcam

Produce publication quality images and benefit from greater sensitivity, improved signal-to-noise ratio as well as reduced background with Abcam’s EXPOSE IHC biotin-free detection systems. Visit us at Booth 349 at the 2012 Convention. MORE


Enzymatic etching used to build nanoscale surface topologies
R&D Magazine    Share    Share on FacebookTwitterShare on LinkedinE-mail article
In living systems, complex nano- and microscale structures perform a host of physical and biological functions. While two-dimensional patterns can be recreated fairly well with techniques like microlithography, three-dimensional structures represent a big challenge. In the journal Angewandte Chemie, researchers have now reported a new method for the lithography-free etching of complex surface motifs with the use of biodegradable polymers and enzymes. Starting with structured microchannels, they have built an assembly for the isolation and concentration of cells from whole blood. More

DispoCut™ Disposable Dissecting Boards

Lab Storage Systems is proud to offer the DispoCut™ disposable dissecting board. This dissecting board is strong enough to reuse, yet inexpensive enough to throw away. Conveniently printed on both sides in inches and metric measurements. Available in 3 sizes. MORE


Live-cell analysis of autophagy
Bioscience Technology    Share    Share on FacebookTwitterShare on LinkedinE-mail article
Analysis of subcellular structure dynamics has been revolutionized in the past 15 years by the refinement of genetically encoded fusions between fluorescent proteins and cellular structural proteins. Such fusion proteins incorporate into the structure of interest without disturbing its function, and permit visualization of the structure in live cells and in real time by fluorescence microscopy. More

Living tissue is laced with electronic sensors
Nanotechweb.org    Share    Share on FacebookTwitterShare on LinkedinE-mail article
Embedding electronic circuitry inside human tissue has long been a mainstay of science fiction. Now, scientists in the U.S. have devised a way to grow a culture of live tissue over a matrix containing tiny electronic sensors. As well as leading to better tissue cultures for drug testing, the work could also contribute to the development of synthetic replacement organs. More



Cancer's Achilles' heel?
Genetic Engineering & Biotechnology News    Share    Share on FacebookTwitterShare on LinkedinE-mail article
Scientists have identified a subtype of cancer stem cell that appears to be linked with acquired resistance to chemotherapy and may represent a tumor's therapeutic Achilles' heel. A Columbia University-led team used in-vitro and in-vivo models of prostate cancer to identify a subpopulation of cancer cells that survive docetaxel therapy. These cells lacked differentiation markers and HLA class I antigens, but overexpressed Notch and Hedgehog signaling pathways, and demonstrated potent tumor-initiating capacity. More


Spring Bioscience - BRAF V600E

Spring Bioscience is leading the research industry by pioneering novel, next generation antibodies that can differentiate mutant and normal protein, enabling pathologists to see relevant mutations within their cellular context. Having already released Exon19 and EGFR L858R for exclusive use by Ventana Medical Systems, Spring Bioscience has launched BRAF V600E.
Click here to find out more.
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RDO RAPID DECALCIFIER
RDO Rapid Decalcifier is a major improvement to histological processing procedures. Compared with other commercially available decalcifiers, RDO gently decalcifies specimens in a fraction of the time.
 

Under the Microscope
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