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 Top Stories

Self-regulating networks dictate the genetic program of tumor cells
Medical Xpress    Share    Share on FacebookTwitterShare on LinkedinE-mail article
Scientists at Charité-Universitätsmedizin Berlin could explain a yet unknown regulatory network that controls the growth of tumor cells. Understanding such networks is an important task in molecular tumor biology in order to decode the relationships between the determinants defining which molecules are produced and in what quantities, in both normal and tumor cells. The study is published in the journal Molecular Systems Biology. More



The cell secretome bagged and tagged
Genetic Engineering & Biotechnology News    Share    Share on FacebookTwitterShare on LinkedinE-mail article
A technology that allows scientists to isolate and interrogate a cell's secretory pathway organelles has demonstrated that current techniques for analyzing a cell's secretory output may be missing a large number of potentially key proteins. One way that cells communicate with each other is through the production and signaling of secretory proteins, and current techniques for identifying such proteins uses mass spectrometry-based analysis of the growth medium to see what the cells are adding to what's already present. More

New biomarkers could offer vital clues for cancer research
ADVANCE for Medical Laboratory Professionals    Share    Share on FacebookTwitterShare on LinkedinE-mail article
A unique strategic research initiative in Sweden, called BioCARE, currently under way at the Universities of Lund and Gothenburg, is taking an in-depth look at the role of biomarkers in cancer research. A biomarker is any characteristic that can be objectively measured and evaluated as an indicator of normal biological processes, pathogenic processes or pharmacologic responses to a therapeutic intervention. More

Stellaris RNA FISH Probes

Stellaris RNA FISH is a new research technology that enables direct detection, localization and quantification of RNA. The low cost per assay, simple protocol, and the ability to localize mRNA and lncRNA to organelles and cellular structures provides obvious benefits for life science research. Custom and catalogued probes sets available. MORE


Clinical pathology laboratories ignore the rapid growth of mobile apps in health care at their peril
Dark Daily    Share    Share on FacebookTwitterShare on LinkedinE-mail article
Experts predict that health care's use of mobile apps — now being described as mHealth — will evolve into a distinct and primary information channel that will play a significant role in clinical care. This includes how anatomic and clinical pathologists use laboratory medicine to support clinical care. "Mobile is a technology that winds its way through everything we're doing and we're planning to do," declared Bryan Sivak, chief technology officer at the U.S. Department of Health & Human Services, in a recent story published in Modern Healthcare. More


 In the News


Helium ion microscope receives enhancement
R&D Magazine    Share    Share on FacebookTwitterShare on LinkedinE-mail article
Carl Zeiss Microscopy has introduced the Orion NanoFab, a multi-ion-beam tool based on gas field ion source technology. As an enhancement to the existing helium ion microscope, Orion NanoFab also uses neon ions. The system is therefore capable of providing a complete sub-10 nm nanofabrication and sub-nanometer imaging solution. An optional gallium focused ion beam column can also be integrated. More



Device measures 768 biomolecular interactions simultaneously
Laboratory Equipment    Share    Share on FacebookTwitterShare on LinkedinE-mail article
Scientists at The École Polytechnique Fédérale de Lausanne and the University of Geneva have developed a microfluidic device smaller than a domino that can simultaneously measure up to 768 biomolecular interactions. Inside our cells, molecules are constantly binding and separating from one another. It's this game of constant flux that drives gene expression asides essentially every other biological process. More


New SOX-11 (MRQ-58) for MCL!
SOX-11 expression is specific for the identification of cyclin D1 negative mantle cell lymphoma. SOX-11 is useful due to its high expression in cyclin D1 positive and negative MCL. Many B-cell lymphomas can mimic MCL; therefore, it’s important to have additional antibodies to detect cyclin D1 negative MCL. Learn More.
Human on Human Detection Kits
GBI Labs’s Klear Human Polymer Detection kits can detect human primary antibody on human tissue with no background. It is a biotin-free system. Special blocking buffer and human antibody enhancer are used to provide excellent sensitivity and high specificity. MORE
StatClick™ Specimen Transport Vials
We’ve added a click and removed the leak. Turn the lid until it clicks. Ship with confidence that your samples and your reputation will stay perfectly preserved. To learn more, please visit us at: www.statlab.com/statclick or contact us at 800-442-3573.


Professor publishes on 1st imaging of cells growing on spherical surfaces
PhysOrg    Share    Share on FacebookTwitterShare on LinkedinE-mail article
Florida Institute of Technology assistant professor of mechanical and aerospace engineering Shengyuan Yang and graduate student Sang Joo Lee have published a paper on the first imaging of cells growing on spherical surfaces. The potential biomedical applications of the researchers' technique include new strategies and devices for the early detection and isolation of cancer cells, facilitating new methods of treating cancer tissues. More



A role of ghrelin in canine mammary carcinoma cells proliferation, apoptosis and migration
BMC Veterinary Research    Share    Share on FacebookTwitterShare on LinkedinE-mail article
Ghrelin is a natural ligand of the growth hormone secretagogue receptor. They are often co-expressed in multiple human tumors and related cancer cell lines what can indicate that the ghrelin/GHS-R axis may have an important role in tumor growth and progression. However, a role of ghrelin in canine tumors remains unknown. Thus, the aim of this study was two-fold: to assess expression of ghrelin and its receptor in canine mammary cancer and to examine the effect of ghrelin on carcinoma cells proliferation, apoptosis, migration and invasion. More


Digital Pathology Tools for Biomarker Research
PerkinElmer offers a range of solutions including streamlined TMA & whole slide scanners, patented multispectral imaging and analysis and automated quantitation of biomarkers in tissue. www.perkinelmer.com/tissueimaging
Abcam

Produce publication quality images and benefit from greater sensitivity, improved signal-to-noise ratio as well as reduced background with Abcam’s EXPOSE IHC biotin-free detection systems. Visit us at Booth 349 at the 2012 Convention. MORE


'Fingerprinting' breakthrough offers improved brain tumor diagnosis
Medical Xpress    Share    Share on FacebookTwitterShare on LinkedinE-mail article
U.K. scientists have made a breakthrough in a new method of brain tumor diagnosis, offering hope to tens of thousands of people. Researchers, led by professor Francis Martin of Lancaster Environment Center at Lancaster University, have shown that infrared and Raman spectroscopy — coupled with statistical analysis — can be used to tell the difference between normal brain tissue and the different tumor types that may arise in this tissue, based on its individual biochemical-cell "fingerprint." More

DispoCut™ Disposable Dissecting Boards

Lab Storage Systems is proud to offer the DispoCut™ disposable dissecting board. This dissecting board is strong enough to reuse, yet inexpensive enough to throw away. Conveniently printed on both sides in inches and metric measurements. Available in 3 sizes. MORE


Researchers track gene expression to create atlas of human brain
redOrbit    Share    Share on FacebookTwitterShare on LinkedinE-mail article
A research team from the Allen Institute for Brain Science reports that human brains share a consistent genetic blueprint and possess enormous biochemical complexity. The findings, published in Nature, stem from the first in-depth and large-scale analysis of the vast data set publicly available in the Allen Human Brain Atlas. It details genes at work throughout the human brain with data incorporated from magnetic resonance imaging and diffusion tensor imaging as well as histology and gene expression data derived from both microarray and in situ hybridization approaches. More

In 5 years, you may be wearing a lab-grown leather jacket
Fast Company    Share    Share on FacebookTwitterShare on LinkedinE-mail article
Modern Meadow — a lab-grown meat startup — is getting closer and closer to growing leather in a test tube. But that's just the beginning. Why grow regular leather when you can use your lab to make leather better through tissue engineering? More



Baxter robot brings automation to smaller manufacturers
Eureka    Share    Share on FacebookTwitterShare on LinkedinE-mail article
A humanoid robot designed to apply common sense behavior to manufacturing tasks has been launched by Rethink Robotics. Dubbed Baxter, the robot relies on a combination of cameras, sensors, elastic actuators and a quad-core processor to adapt to real world imperfections. Electric parallel grippers enable it to pick up a range of objects of varying sizes. More


Spring Bioscience - BRAF V600E

Spring Bioscience is leading the research industry by pioneering novel, next generation antibodies that can differentiate mutant and normal protein, enabling pathologists to see relevant mutations within their cellular context. Having already released Exon19 and EGFR L858R for exclusive use by Ventana Medical Systems, Spring Bioscience has launched BRAF V600E.
Click here to find out more.
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RDO RAPID DECALCIFIER
RDO Rapid Decalcifier is a major improvement to histological processing procedures. Compared with other commercially available decalcifiers, RDO gently decalcifies specimens in a fraction of the time.
 

Under the Microscope
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