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Gen Y physicians — including young pathologists — bring different goals and values to their practice of medicine
Dark Daily    Share    Share on FacebookTwitterShare on LinkedinE-mail article
As they hire young pathologists, pathology groups and clinical laboratories will need to factor in the generational preferences of these Gen Y physicians. Gen Y doctors take a much different approach to the practice of medicine than the Gen X and baby boomer doctors who preceded them. It will be important for clinical laboratories and pathology groups serving Gen Y physicians to understand these important differences. While Gen Y doctors remain just as dedicated to the high standards of medicine as their predecessors, the current crop of young doctors approach the practice of medicine with a much broader worldview than previous generations of physicians, according to a recent story in Modern Healthcare. More

Rabbit Monoclonals for Anatomic Pathology
Introducing rabbit monoclonal antibody (RabMAb®) cocktails from Epitomics. The CK5/CK6/ERG cocktail was introduced this year along with four other varieties targeting breast cancers and prostate cancers. Antibody cocktails represent an important tool in IHC applications for examining diagnostically challenging tissue specimens. For more information about these antibodies,
click here.


Animals engineered with pinpoint accuracy
Nature    Share    Share on FacebookTwitterShare on LinkedinE-mail article
Two genetically engineered farm animals illustrate how far animal biotechnology has come from the days of Frankenstein's stitched-together monster. One of those animals, a cow, secretes milk that lacks an allergy-inducing protein because researchers accurately blocked its production using the technique of RNA interference. And in pigs, scientists have used an enzyme called a TALEN to scramble a gene that would normally help remove cholesterol. RNA interference and TALENs are more accurate at targeting the gene in question than are earlier genetic engineering techniques. More

Bizarre tumor case may lead to custom cancer care
The Associated Press via USA Today    Share    Share on FacebookTwitterShare on LinkedinE-mail article
It's a medical nightmare: A 24-year-old man endures 350 surgeries since childhood to remove growths that keep coming back in his throat and have spread to his lungs, threatening his life. Now doctors have found a way to help him by way of a scientific coup that holds promise for millions of cancer patients. The bizarre case is the first use in a patient of a new discovery: how to keep ordinary and cancerous cells alive indefinitely in the lab. More

Stellaris RNA FISH Probes

Stellaris RNA FISH is a new research technology that enables direct detection, localization and quantification of RNA. The low cost per assay, simple protocol, and the ability to localize mRNA and lncRNA to organelles and cellular structures provides obvious benefits for life science research. Custom and catalogued probes sets available. MORE


Potential new class of drugs blocks nerve cell death
Science Codex    Share    Share on FacebookTwitterShare on LinkedinE-mail article
Diseases that progressively destroy nerve cells in the brain or spinal cord, such as Parkinson's disease and amyotrophic lateral sclerosis, are devastating conditions with no cures. Now, a team that includes a University of Iowa researcher has identified a new class of small molecules, called the P7C3 series, which block cell death in animal models of these forms of neurodegenerative disease. The P7C3 series could be a starting point for developing drugs that might help treat patients with these diseases. More


 NSH News


2012 Award/Scholarship recipients
NSH    Share    Share on FacebookTwitterShare on LinkedinE-mail article
NSH would like to congratulate the following 2012 Awards/Scholarship recipients. More


 In the News


Biological markers increase clinical trial success rate of new breast cancer drugs
Medical Xpress    Share    Share on FacebookTwitterShare on LinkedinE-mail article
Using biological markers — genetic characteristics that are associated with some patients with breast cancer — can increase the success rate of clinical trials for breast cancer drugs by almost 50 percent, says new research from the University of Toronto Mississauga. "It's been increasingly difficult for pharmaceutical companies to bring new drugs to market," says Jayson Parker, a faculty member in the Department of Biology and medical biotechnology analyst at the University of Toronto. "On average, about 80 percent of drugs fail at some point in the clinical trial process." More



Antibiotic cures disease by disarming pathogens
Laboratorytalk    Share    Share on FacebookTwitterShare on LinkedinE-mail article
Scientists are in a race to develop drugs that can treat infections with the bacterium Acinetobacter baumannii — a pathogen that most often strikes hospital patients through open wounds, breathing tubes or catheters. Strains of A. baumannii have acquired resistance to a wide range of antibiotics, and some are resistant to every FDA-approved antibiotic, making them untreatable. "Traditionally, people have tried to find antibiotics that rapidly kill bacteria. But we found a new class of antibiotics which has no ability to kill Acinetobacter that can still protect, not by killing the bug, but by completely preventing it from turning on host inflammation," Brad Spellberg of the UCLA Medical Center said. More


New SOX-11 (MRQ-58) for MCL!
SOX-11 expression is specific for the identification of cyclin D1 negative mantle cell lymphoma. SOX-11 is useful due to its high expression in cyclin D1 positive and negative MCL. Many B-cell lymphomas can mimic MCL; therefore, it’s important to have additional antibodies to detect cyclin D1 negative MCL. Learn More.
Human on Human Detection Kits
GBI Labs’s Klear Human Polymer Detection kits can detect human primary antibody on human tissue with no background. It is a biotin-free system. Special blocking buffer and human antibody enhancer are used to provide excellent sensitivity and high specificity. MORE
StatClick™ Specimen Transport Vials
We’ve added a click and removed the leak. Turn the lid until it clicks. Ship with confidence that your samples and your reputation will stay perfectly preserved. To learn more, please visit us at: www.statlab.com/statclick or contact us at 800-442-3573.


Gene research in the cloud could help cure diseases in the lab
GigaOM    Share    Share on FacebookTwitterShare on LinkedinE-mail article
Understanding the nature of human stem cells and being able to identify and compare their characteristics is crucial for medical research. That's why Morgridge Institute, a nonprofit biomedical researcher based in Madison, Wis., used Cycle Computing's software atop Amazon Web Services infrastructure to process and index human stem cells to build an extensive knowledge base. More



Optimized substance forces cancer cells into death
R&D Magazine    Share    Share on FacebookTwitterShare on LinkedinE-mail article
Many tumor cells have a defective cellular equipment. It is only by a special trick that they manage to distribute their chromosomes correctly to their daughter cells during cell division. Scientists of the German Cancer Research Center have now developed a substance that thwarts this trick and forces cancer cells into death during cell division. The group has now reported their results in the journal Cancer Research. More

Making old muscles young
Laboratorytalk    Share    Share on FacebookTwitterShare on LinkedinE-mail article
The discovery was made by researchers at King's College London, Harvard University and Massachusetts General Hospital. Although an early study, the finding provides clues as to how muscles lose mass with age, which can result in weakness that affects mobility and may cause falls. A dormant reservoir of stem cells is present inside every muscle, ready to be activated by exercise and injury to repair any damage. When needed, these cells divide into hundreds of new muscle fibers that repair the muscle. More


DIGITAL HOLOGRAPHY FOR CELL STUDY

NanoAndMore USA provides DHMs from Lyncée tec and Resolution Optics. They sense the change in the liquid content of cells and image in 3D.
MORE
Sensitive and specific 2-plex RNA-ISH assay

Affymetrix’ QuantiGene® ViewRNA Assays enable single-copy RNA sensitivity with exceptional specificity in FFPE tissue sections. From sequence to assay in 1 week. View recent publications.


New technologies and methods push imaging capabilities
Laboratory Equipment    Share    Share on FacebookTwitterShare on LinkedinE-mail article
Imaging used to be simply defined as the representation of an object's external form. That definition no longer holds true as researchers now look for more than just an image. They look for more information within an image, such as fluorescent tags, mechanobiological parameters, internal structures, fabrication while imaging and the characterization of materials as yet undefined. The images are increasingly becoming extremely small, most of them now being measured in nanometers. In this article, seven new imaging technologies and solutions for research and processing applications are explored. More

DispoCut™ Disposable Dissecting Boards

Lab Storage Systems is proud to offer the DispoCut™ disposable dissecting board. This dissecting board is strong enough to reuse, yet inexpensive enough to throw away. Conveniently printed on both sides in inches and metric measurements. Available in 3 sizes. MORE


Eye measures tied to brain pathology in MS
MedPage Today    Share    Share on FacebookTwitterShare on LinkedinE-mail article
Retinal thickness as measured with a high-tech ocular scanner in multiple sclerosis patients correlated significantly with the volumes of certain brain structures, researchers said. Cortical gray matter and caudate volumes were associated with thickness of the peripapillary retinal nerve fiber layer and with the composite ganglion cell layer plus inner plexiform layer in MS patients with no history of optic neuritis, reported Shiv Saidha, MBBCh, of Johns Hopkins University, and colleagues. To their surprise, the researchers also found that the retinal thickness measurements also correlated significantly with intracranial volume — a relatively fixed measure of skull size — in the MS patients and in healthy controls. More


Digital Pathology Tools for Biomarker Research
PerkinElmer offers a range of solutions including streamlined TMA & whole slide scanners, patented multispectral imaging and analysis and automated quantitation of biomarkers in tissue. www.perkinelmer.com/tissueimaging
CAP/NSH HistoQIP Specialty Series
The CAP’s HistoQIP Specialty Series includes modules to improve the preparation of slides in specialty laboratories, like outpatient gastrointestinal, dermatologic, and urologic tract histology laboratories.


Animal models get closer to mimicking humans
Genetic Engineering & Biotechnology News    Share    Share on FacebookTwitterShare on LinkedinE-mail article
Animal models contribute significantly to our understanding of molecular mechanisms underlying disease pathologies. However, few models predictably translate preclinical findings into what will happen in humans. Investigational drugs are able to cure mice from many diseases, but continue to fail in clinical trials. This fact is largely attributed to poor model designs that do not sufficiently reflect the pathophysiology of disease in humans. In addition, tremendous diversity of human genetic background, co-medications, dosing, timing of treatment and many other factors greatly influence the treatment outcome. The new generation of animal models, described in this article, takes into consideration previous shortcomings. These models aim to reflect the human condition as closely as possible and to close the gap between translational research and the bedside. More



Genome project links breast and ovarian cancers
USA Today    Share    Share on FacebookTwitterShare on LinkedinE-mail article
Scientists announced they have finished mapping virtually all of the genetic mutations in breast cancer, an effort that could soon change the way patients are treated and eventually help researchers develop better treatments. Among the most striking findings: One of the most lethal types of breast cancer is genetically closer to a kind of ovarian cancer than it is to other breast tumors, according to the paper, published online in Nature. More


Spring Bioscience - BRAF V600E

Spring Bioscience is leading the research industry by pioneering novel, next generation antibodies that can differentiate mutant and normal protein, enabling pathologists to see relevant mutations within their cellular context. Having already released Exon19 and EGFR L858R for exclusive use by Ventana Medical Systems, Spring Bioscience has launched BRAF V600E.
Click here to find out more.
Get your histology CE from MediaLab

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RDO RAPID DECALCIFIER
RDO Rapid Decalcifier is a major improvement to histological processing procedures. Compared with other commercially available decalcifiers, RDO gently decalcifies specimens in a fraction of the time.
 

Under the Microscope
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