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 Top Stories

Future of pathology informatics and LIS
Dark Daily    Share    Share on FacebookTwitterShare on LinkedinE-mail article
In the field of medical laboratory informatics, there is an emerging trend of great importance to both clinical laboratories and pathology groups. It is becoming increasingly tougher for hospital labs to select a "best-of-breed" laboratory information system. That's because more hospital administrators are opting for a single "enterprisewide" informatics/EHR solution that commonly includes an LIS that is not the first choice of laboratory management. More

Rabbit Monoclonals for Anatomic Pathology
Introducing rabbit monoclonal antibody (RabMAb®) cocktails from Epitomics. The CK5/CK6/ERG cocktail was introduced this year along with four other varieties targeting breast cancers and prostate cancers. Antibody cocktails represent an important tool in IHC applications for examining diagnostically challenging tissue specimens. For more information about these antibodies,
click here.


MIT team builds most complex synthetic biology circuit yet
Science Blog    Share    Share on FacebookTwitterShare on LinkedinE-mail article
Using genes as interchangeable parts, synthetic biologists designed cellular circuits that can perform new functions, such as sensing environmental conditions. However, the complexity that can be achieved in such circuits has been limited by a critical bottleneck: the difficulty in assembling genetic components that don't interfere with each other. More

US scientists aim to make human sperm from stem cells
BBC News    Share    Share on FacebookTwitterShare on LinkedinE-mail article
U.S. researchers say they will redouble their efforts to create human sperm from stem cells following the success of a Japanese study involving mice. A Kyoto University team used mice stem cells to create eggs, which were fertilized to produce baby mice. Dr. Renee Pera, of Stanford University in California, aims to create human sperm to use for reproduction within two years, and eggs within five years. More

Stellaris RNA FISH Probes

Stellaris RNA FISH is a new research technology that enables direct detection, localization and quantification of RNA. The low cost per assay, simple protocol, and the ability to localize mRNA and lncRNA to organelles and cellular structures provides obvious benefits for life science research. Custom and catalogued probes sets available. MORE


Scratching the surface: Engineers examine UV effects on skin mechanics
Medical Xpress    Share    Share on FacebookTwitterShare on LinkedinE-mail article
Reinhold Dauskardt, Ph.D., of Stanford's Department of Materials Science and Engineering has been studying skin for years. But when he sent his students to look for data on the mechanical properties of skin, they came back empty-handed. A lot was known about skin structure and disease, but few papers actually talked about its mechanical function — its ability to stretch and resist tension without tearing. "That motivated us to get more interested in the skin itself," said Dauskardt. More


 In the News


Stem cell transplants come back to haunt
MedPage Today    Share    Share on FacebookTwitterShare on LinkedinE-mail article
Long-term survivors of blood-related cancers who had stem cell transplants are at risk of developing risk factors that can lead to heart disease, researchers found. Overall, the presence of hypertension, diabetes and dyslipidemia was significantly higher among hematopoietic cell transplant recipients compared with the general population, according to Saro H. Armenian, DO, MPH, of City of Hope in Duarte, Calif., and colleagues. More



Tissue engineering no easy cell
Genetic Engineering & Biotechnology News    Share    Share on FacebookTwitterShare on LinkedinE-mail article
Dr. Nina Tandon dazzled attendees at the TEDx conference recently by crystallizing years of recent research into an encouraging vision of a new paradigm of medicine she calls Body 3.0. "There is a shift philosophically from the idea of, 'OK let's build a hip,' to, 'Let's build an environment like a fancy fish tank, so to speak' — we call them bioreactors — that allow cells to build a piece of bone themselves," said Tandon, senior fellow at Columbia University's Lab for Stem Cells and Tissue Engineering. More


DIGITAL HOLOGRAPHY FOR CELL STUDY

NanoAndMore USA provides DHMs from Lyncée tec and Resolution Optics. They sense the change in the liquid content of cells and image in 3D.
MORE
Sensitive and specific 2-plex RNA-ISH assay

Affymetrix’ QuantiGene® ViewRNA Assays enable single-copy RNA sensitivity with exceptional specificity in FFPE tissue sections. From sequence to assay in 1 week. View recent publications.


Prostate cancer genetic 'signatures' could predict who will have aggressive tumors
Reuters via The Huffington Post    Share    Share on FacebookTwitterShare on LinkedinE-mail article
Scientists have found two distinct genetic "signatures" for prostate cancer that may help doctors predict which patients have aggressive tumors, and designed experimental blood tests to read those genetic signs like barcodes. The teams, whose work was published in the Lancet Oncology journal, believe tests developed from the signatures could eventually be used to tell which patients need immediate treatment. More



Gene therapy gets the blue light
COSMOS    Share    Share on FacebookTwitterShare on LinkedinE-mail article
U.S. researchers have developed a system, triggered by blue light, that can seek out and turn on or off any desired gene, which could be useful for research in biotechnology and in medicine. This is the first time specific sections of DNA have been turned on and off. The researchers could control where and when a gene was turned on, and how quickly this happened. They also report tuning the level of gene expression using the intensity of the light in their paper published in the Journal of the American Chemical Society. More

Faster cancer treatment with genome superhighway
Science Codex    Share    Share on FacebookTwitterShare on LinkedinE-mail article
A new supercomputer-based network will allow doctors to use genomic sequencing to speed cancer treatment and could increase survival chances for patients, its creator, billionaire healthcare businessman Dr. Patrick Soon-Shiong said. A group of technology and healthcare companies have formed the superhighway that will accelerate the time for genetic analysis of a patient's tumor to 47 seconds from eight to 10 weeks now, Soon-Shiong said. More


New SOX-11 (MRQ-58) for MCL!
SOX-11 expression is specific for the identification of cyclin D1 negative mantle cell lymphoma. SOX-11 is useful due to its high expression in cyclin D1 positive and negative MCL. Many B-cell lymphomas can mimic MCL; therefore, it’s important to have additional antibodies to detect cyclin D1 negative MCL. Learn More.
Human on Human Detection Kits
GBI Labs’s Klear Human Polymer Detection kits can detect human primary antibody on human tissue with no background. It is a biotin-free system. Special blocking buffer and human antibody enhancer are used to provide excellent sensitivity and high specificity. MORE
StatClick™ Specimen Transport Vials
We’ve added a click and removed the leak. Turn the lid until it clicks. Ship with confidence that your samples and your reputation will stay perfectly preserved. To learn more, please visit us at: www.statlab.com/statclick or contact us at 800-442-3573.


Cell biology pioneers win Nobel Prize in medicine
Nigerian Tribune    Share    Share on FacebookTwitterShare on LinkedinE-mail article
The 2012 Nobel Prize for Physiology or Medicine was awarded to Sir John B. Gurdon and Shinya Yamanaka for work that revolutionized the understanding of how cells and organisms develop. The Nobel Assembly's announcement at the Karolinska Institute in Stockholm is the first for what will be a series of prizes announced. The Norwegian Nobel committee will announce the most anticipated of the annual honors the Nobel Peace Prize in Oslo. More

DispoCut™ Disposable Dissecting Boards

Lab Storage Systems is proud to offer the DispoCut™ disposable dissecting board. This dissecting board is strong enough to reuse, yet inexpensive enough to throw away. Conveniently printed on both sides in inches and metric measurements. Available in 3 sizes. MORE


Morphing brain cells for regenerative therapy
Genetic Engineering & Biotechnology News    Share    Share on FacebookTwitterShare on LinkedinE-mail article
Scientists have managed to reprogram non-neuronal pericytes found in the human brain directly into action potential-firing immature neurons, using just two transcription factors. The achievement, carried out in cultures of human brain tissue in vitro, could feasibly pave the way to the development of new regenerative treatments for traumatic brain injury or neurodegenerative disorders such as Alzheimer's disease or Parkinson's disease, claim researchers who headed the studies. More


Digital Pathology Tools for Biomarker Research
PerkinElmer offers a range of solutions including streamlined TMA & whole slide scanners, patented multispectral imaging and analysis and automated quantitation of biomarkers in tissue. www.perkinelmer.com/tissueimaging
CAP/NSH HistoQIP Specialty Series
The CAP’s HistoQIP Specialty Series includes modules to improve the preparation of slides in specialty laboratories, like outpatient gastrointestinal, dermatologic, and urologic tract histology laboratories.


Omega-3 supplements may slow a biological effect of aging
Bioscience Technology    Share    Share on FacebookTwitterShare on LinkedinE-mail article
Taking enough omega-3 fatty acid supplements to change the balance of oils in the diet could slow a key biological process linked to aging, new research suggests. The study showed that most overweight but healthy middle-age and older adults who took omega-3 supplements for four months altered a ratio of their fatty acid consumption in a way that helped preserve tiny segments of DNA in their white blood cells. These segments, called telomeres, are known to shorten over time in many types of cells as a consequence of aging. More



Doctor travels from China to Wisconsin for advanced training in skin diseases
Manitowoc Herald Times Reporter    Share    Share on FacebookTwitterShare on LinkedinE-mail article
VideoBriefTo the untrained eye, the skin tissue under the microscope appears nothing more than a pink shape accented with purple dots and squiggles. Dr. Ling Xia, a dermatologist with Dermatology Associates of Wisconsin in Manitowoc, can point out each hair follicle and every cell nucleus as he looks for diseases ranging from inflammation and infection to benign and malignant tumors. Hoping to benefit from his expertise in diagnosing skin diseases under the microscope, Dr. Jun Ye, a Chinese dermatologist, spent September in Manitowoc studying with Xia in the pathology lab. More


Spring Bioscience - BRAF V600E

Spring Bioscience is leading the research industry by pioneering novel, next generation antibodies that can differentiate mutant and normal protein, enabling pathologists to see relevant mutations within their cellular context. Having already released Exon19 and EGFR L858R for exclusive use by Ventana Medical Systems, Spring Bioscience has launched BRAF V600E.
Click here to find out more.
Get your histology CE from MediaLab

Explore our online interactive histology courses, and discover the latest secrets for creating flawless IHC, FISH, special, and routine stains. Complete your annual safety and compliance training hassle free. Document training and get P.A.C.E credits with the included Learning Management System. Get it all with our unlimited annual subscription, available for both individuals and institutions.
RDO RAPID DECALCIFIER
RDO Rapid Decalcifier is a major improvement to histological processing procedures. Compared with other commercially available decalcifiers, RDO gently decalcifies specimens in a fraction of the time.
 

Under the Microscope
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