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Only 3 NSH webinars left for 2013 — register today!
The 2013 NSH Webinars are finishing up with great content you won't want to miss. These webinars are an easy way to earn those continuing education credits and you even have access to the recordings if you miss the live event. The three final webinars include, Building Effective Teams by Lois Anderson, CM, An Introduction to Commonly Used Immunohistochemical Stains in Dermatopathology by Dr. Alison Uzeblo & Double IHC Staining by Charlie Dorner. Click here to register.
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Breaking through cancer's shield
The New York Times
For more than a century, researchers were puzzled by the uncanny ability of cancer cells to evade the immune system. They knew cancer cells were grotesquely abnormal and should be killed by white blood cells. In the laboratory, in Petri dishes, white blood cells could go on the attack against cancer cells. Why, then, could cancers survive in the body? The answer, when it finally came in recent years, arrived with a bonus: a way to thwart a cancer's strategy. Researchers discovered that cancers wrap themselves in an invisible protective shield. And they learned that they could break into that shield with the right drugs.
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Doctors search for vaccine to prevent breast cancer
USA Today
Forty years ago, women who had abnormal results on a Pap smear often wound up with a hysterectomy. Doctors removed their uterus because they had no other way to prevent women from developing cervical cancer, researcher Susan Love says. Today, she says, doctors can prevent cervical cancer with a vaccine. That has led some to ask: Could researchers develop a vaccine against breast cancer?
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Beyond antibiotics: PPMOs offer new approach to bacterial infection
R&D Magazine
Researchers at Oregon State University and other institutions announced the successful use of a new type of antibacterial agent called a PPMO, which appears to function as well or better than an antibiotic, but may be more precise and also solve problems with antibiotic resistance.
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Simple urine test uses nanotechnology to detect dangerous blood clotting
Life-threatening blood clots can form in anyone who sits on a plane for a long time, is confined to bed while recovering from surgery, or takes certain medications. There is no fast and easy way to diagnose these clots, which often remain undetected until they break free and cause a stroke or heart attack. However, new technology from MIT may soon change that: A team of engineers has developed a way to detect blood clots using a simple urine test. The noninvasive diagnostic, described in a recent issue of the journal ACS Nano, relies on nanoparticles that detect the presence of thrombin, a key blood-clotting factor.
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Looking for similar articles? Search here, keyword URINE TESTS.

Stellaris RNA FISH Probes

Stellaris RNA FISH is a new research technology that enables direct detection, localization and quantification of RNA. The low cost per assay, simple protocol, and the ability to localize mRNA and lncRNA to organelles and cellular structures provides obvious benefits for life science research. Custom and catalogued probes sets available. MORE
ergoCentric Laboratory Seating

Visit LabStorage System’s updated website to view details about this new laboratory seating with specially formulated Infection Control coating. Non-porous and easily disinfected, this moisture proof coating is anti-bacterial, anti-fungal and stain resistant. more
Spring Bioscience - BRAF V600E

Spring Bioscience is leading the research industry by pioneering novel, next generation antibodies that can differentiate mutant and normal protein, enabling pathologists to see relevant mutations within their cellular context. Having already released Exon19 and EGFR L858R for exclusive use by Ventana Medical Systems, Spring Bioscience has launched BRAF V600E.
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In a surprise finding, gene mutation found linked to low-risk bladder cancer
Science Codex
An international research team led by scientists from Georgetown Lombardi Comprehensive Cancer Center has discovered a genetic mutation linked to low-risk bladder cancer. Their findings are reported online in Nature Genetics. The investigators identified STAG2 as one of the most commonly mutated genes in bladder cancer, particularly in tumors that do not spread. The finding suggests that checking the status of the gene may help identify patients who might do unusually well following cancer treatment, says the study's senior investigator, cancer geneticist Todd Waldman, MD, PhD, a professor of oncology at Georgetown Lombardi.
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Common food additive may prevent peripheral neuropathy from chemotherapy
Oncology Nurse Advisor
Working with cells in test tubes and in mice, researchers discovered that a chemical commonly used as a dog food preservative prevents chemotherapy-associated peripheral neuropathy. Four of every five patients with cancer receiving chemotherapy with paclitaxel experience the painful condition. Ethoxyquin is an antioxidant that is approved by the FDA as a preservative. Experiments found that it binds certain cell proteins in a way that limits their exposure to the damaging effects of paclitaxel. The research was published in Annals of Neurology.
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Experiment reveals the ugly side of open-source journal industry
By Pamela Lewis Dolan
Over the past 10 months, Harvard researcher John Bohannon, Ph.D., has created more than 300 versions of a phony research paper describing the anticancer property of a chemical extracted from a lichen. Despite Bohannon’s efforts to make the papers flawed and unpublishable, nearly 160 medical journal publishers accepted the paper for publishing, despite each one claiming to have a peer review process. It was never Bohannon's intent to actually get the papers published. Rather, his goal was to expose the growing trend of predatory practices among open-source journal publishers that charge fees to publish an author's work.
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Compound derived from vegetables shields rodents from lethal radiation doses
Medical Xpress
Georgetown University Medical Center researchers say a compound derived from cruciferous vegetable such as cabbage, cauliflower, and broccoli protected rats and mice from lethal doses of radiation. Their study, published Oct. 14 in the Proceedings of the National Academy of Sciences suggests the compound, already shown to be safe for humans, may protect normal tissues during radiation therapy for cancer treatment and prevent or mitigate sickness caused by radiation exposure.
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Intelsint Vacuum Tissue Processors
A line of TPs capable to conveniently cover the needs of every Histology lab. Our attention is focused on reliability, flexibility, ease of usage, samples protection and user safety.

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Growing and preparing adult stem cells
Genetic Engineering & Biotechnology News
Diverse factors account for the interest in (and success of) the adult stem cell field in recent years. These factors include breakthroughs in reprogramming, ethical and regulatory issues more tractable than those encountered with embryonic stem cells, and plastics. Diverse factors will likely contribute to the field's future as well. At the "Adult Stem Cell Therapy and Regenerative Medicine Conference" factors such as manipulation, transduction, visualization and homing were considered, as was cell culture.
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Missed last week's issue? See which articles your colleagues read most.

    Shutdown hits patients' hopes for federally funded cancer drug trials (Reuters)
Preventing superbugs by deactivating antibiotics with a flash of light (Popular Science)
Cell-culture transplant possible for neurological disorders (Health Newsline)

Don't be left behind. Click here to see what else you missed.

Blood pressure drug may improve cancer treatment
Oncology Nurse Advisor
Losartan, an angiotensin inhibitor used to treat hypertension, may improve the delivery of chemotherapy drugs and oxygen to solid tumors, according to new research. When cancer-associated fibroblasts proliferate, they produce increased levels of collagen and a gel-like substance called hyaluronan. Collagen and hyaluronan exert physical forces that compress tumor blood vessels, reducing vascular perfusion. A study published in Nature Communications examined whether Losartan and similar drugs could decrease production of collagen and hyaluronan.
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RNAscope: Visualize Single-Copy RNA

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