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Researchers optimistic about curbing effects of peanut allergy
Medill Reports    Share   Share on FacebookTwitterShare on LinkedinE-mail article
A possible way to prevent the inflammatory immune reaction that results from peanut allergies has been reported by researchers at Northwestern University's Feinberg School of Medicine. The lead researchers said it is the first time their particular method for creating immune tolerance has been applied toward allergic diseases. As part of the study, researchers attached peanut proteins onto blood cells and re-infused them into laboratory mice. Increasing the number of T cells in the subjects' blood, researchers attached nut proteins onto white blood cells and infused them into the mice's bloodstreams.They were not able to predict how many years of study are needed before human trials could begin, but they agreed it won't be soon. More



Examining how fibrin works against the patient in the clinical laboratory
ADVANCE for Medical Laboratory Professionals    Share    Share on FacebookTwitterShare on LinkedinE-mail article
When you accidentally cut yourself or are bleeding from an injury, fibrin is your friend. It stops the bleeding and eventually forms a stable mat of tissue that seals the wound from infection while the damaged tissue regenerates. But when you pull red-top tubes from the centrifuge, the same fibrin is your foe. More accurately, it's your patient's foe. That's because fibrin formation in the tube to be tested may lead to instrumentation problems and/or inaccurate results. More


 NSH News


Connect with NSH on Twitter, Facebook, LinkedIn
NSH    Share    Share on FacebookTwitterShare on LinkedinE-mail article
Looking for more ways to know what's going on at the National Society for Histotechnology? Look no further: NSH is on Twitter, Facebook and LinkedIn. More


 In the News


Gut bacteria may keep statin response in check
MedPage Today (free registration required)    Share    Share on
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Various bacterial-derived bile acids appear to influence the response to statin treatment, researchers found. Pretreatment levels of several primary and secondary bile acids were strongly associated with the low-density lipoprotein cholesterol-lowering ability of simvastatin in healthy individuals. The findings "warrant further evaluation of interactions of specific markers for gut microbiota and therapeutic response to statins," the researchers wrote. "Identification of the basis for such interactions may in turn lead to dietary or other interventions that can improve statin efficacy by altering gut microflora." More

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High false-negative rate for HER2 status using Oncotype DX
HealthDay News via Doctors Lounge    Share    Share on FacebookTwitterShare on LinkedinE-mail article
Genomic Health's Oncotype DX test, a human epidermal growth factor receptor 2 assay for breast cancer that uses a method of reverse transcription polymerase chain reaction, has an unacceptable false-negative rate, according to a study. The investigators found that IHC/FISH analysis classified 93 percent of cases as negative, 4 percent as positive and 3 percent as equivocal. Of the IHC/FISH negative cases, 99 percent were also reported as negative by the GHI RT-PCR assay. More


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Mushroom compound appears to improve effectiveness of cancer drugs
Bioscience Technology    Share    Share on
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A compound isolated from a wild, poisonous mushroom appears to help a cancer killing drug fulfill its promise, researchers report. The compound, verticillin A, sensitizes cancer cells to tumor necrosis factor-related apoptosis inducing ligand, a drug which induces cancer cells to self destruct. The compound appears to keep cancer cells from developing resistance to TRAIL. More



Cotton candy glass fibers could heal diabetic wounds
Laboratory Equipment    Share    Share on FacebookTwitterShare on LinkedinE-mail article
Diabetics who suffer from hard-to-heal open wounds may soon have help in the form of a cottony glass material. The glass fiber material could become a source of relief for diabetics fighting infections. It also could be used by battlefield medics or emergency medical technicians to treat wounds in the field. More

South Korean team claims to have cloned coyotes
The Associated Press via Bioscience Technology    Share    Share on FacebookTwitterShare on LinkedinE-mail article
A South Korean team led by disgraced stem cell scientist Hwang Woo-suk is claiming to have cloned coyotes for the first time. The Sooam Biotech Research Foundation said that eight coyotes were born in June. Hwang scandalized the international scientific community in 2005 when his breakthrough human cloning research involving embryonic stem cells was found to have been faked. Hwang and his former colleagues also created the world's first cloned dog, Snuppy, in 2005, and that achievement was independently confirmed. More


New IHC
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New Microtome Blades from Sturkey!
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New October Special from LabStorage!

There is still time to take advantage of this month’s budget friendly special from LabStorage. During October only, take 10% off your choice of products. Stock up now on consumables or place your order for storage cabinets or shelving and receive a 10% discount. More


Why many cells are better than one
Bioscience Technology    Share    Share on FacebookTwitterShare on LinkedinE-mail article
Researchers have quantified the number of possible decisions that an individual cell can make after receiving a cue from its environment, and surprisingly, it’s only two. The first-of-its-kind study combines live-cell experiments and math to convert the inner workings of the cell decision-making process into a universal mathematical language, allowing information processing in cells to be compared with the computing power of machines. More



NorDiag announces new cell separation capability
ADVANCE for Medical Laboratory Professionals    Share    Share on FacebookTwitterShare on LinkedinE-mail article
NorDiag recently announced its Arrow instrument now offers affordable, small footprint walk-away automation for both nucleic acid extraction and cell separation. Kits are available for DNA and cell-based HLA testing. The Arrow can run three unique cell separation protocols for cell depletion or enrichment and can perform nucleic acid extraction on a wide variety of sample types, including blood, cells, plasma, serum and tissue, CE, IVD, according to a company release. ADVANCE spoke with NorDiag president Time Murray about the technology for this Q-and-A. More

Laser IDs blood cell differences
Laboratory Equipment    Share    Share on FacebookTwitterShare on LinkedinE-mail article
Researchers have developed a laser-based analysis method that can detect optical pressure differences between populations or classes of blood cells that does not rely on prior knowledge, antibodies or fluorescent labels for discrimination. When a laser beam impinges on a biological particle, a force is generated due to the scattering and refraction of photons. The resulting force is called optical pressure and can be used to physically move a biological cell, suspended in water, several millimeters. More


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Robot biologist solves complex problem from scratch
R&D Magazine    Share    Share on FacebookTwitterShare on LinkedinE-mail article
An interdisciplinary team of scientists has taken a major step toward this goal by demonstrating that a computer can analyze raw experimental data from a biological system and derive the basic mathematical equations that describe the way the system operates. According to the researchers, it is one of the most complex scientific modeling problems that a computer has solved completely from scratch. More

Study: Bookmarking genes before cell division accelerates subsequent reactivation
Bioscience Technology    Share    Share on FacebookTwitterShare on LinkedinE-mail article
In order for cells of different types to maintain their identities even after repeated rounds of cell division, each cell must "remember" which genes were active before division and pass along that memory to its daughter cells. Cells deal with this challenge by deploying a "bookmarking" process. In the same way a sticky note marks the last-read page in a book, certain molecules tag the active genes in a cell so that, after it divides, the same genes are reactivated right away in the new cells. More


DIGITAL HOLOGRAPHY FOR CELL STUDY

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Milestone
Milestone was founded in 1988 as a company specializing in advanced microwave instrumentation for analytical and organic chemistry labs. MORE


Retroperitoneal lymph node dissection for metastatic germ cell tumor
UroToday    Share    Share on FacebookTwitterShare on LinkedinE-mail article
In England's North Trent Cancer Network patients requiring retroperitoneal lymphadenectomy for metastatic testicular cancer have been treated by vascular service since 1990. This paper reviews the center's experience and considers the case for involvement of vascular surgeons in the management of these tumors. More

Treating spinocerebellar ataxia type 1 using VEGF ameliorates pathology, improves motor function
Genetic Engeineering & Biotechnology News    Share    Share on FacebookTwitterShare on LinkedinE-mail article
Treating the inherited neurodegenerative disease spinocerebellar ataxia type 1 using VEGF improves motor function and restores cerebellar pathology in a mouse model of the disease, suggesting it could represent a therapeutic approach for human patients, scientists claim. A team found that VEGF expression is depressed in the affected brain regions of a mouse model of SCA1, due to the activity of the mutated ataxin-1 gene that causes SCA1. More


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Paperless Histology Tracking from PDS
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Under the Microscope
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