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 Top Stories

How Hurricane Sandy destroyed years of medical research
THE WEEK    Share    Share on FacebookTwitterShare on LinkedinE-mail article
As Hurricane Sandy flooded Lower Manhattan, the staff at New York University's Langone Medical Center rushed to evacuate 300 patients. At another NYU facility, the Smilow Research Building, thousands of lab mice drowned as the storm surge filled the basement with water. Many tissue samples and other specimens also were lost. More

Introducing New RabMAbs for Lymphoma
Introducing new rabbit monoclonal antibodies (RabMAbs®) from Epitomics. Epitomics now has over 170 EP Clones, available in 16 Disease Panels including Lymphoma markers to the following antibodies: CD4, CD10, IgD, MUM1. For more information about these antibodies and the advantages of Rabbit Monoclonal antibodies, click here.


Public outcry over inaccurate medical laboratory test results and misdiagnoses spurs government action in developing countries
Dark Daily    Share    Share on FacebookTwitterShare on LinkedinE-mail article
From Kenya to the Caribbean, clinical laboratory testing failures are making national news. It is both patients and professional associations of laboratory workers who are fueling public debate and government action in response to public disclosures about patient harm as a consequence of errors in medical laboratories testing. More

1st mouse, now human, lab-grown eye tissue
PhysOrg    Share    Share on FacebookTwitterShare on LinkedinE-mail article
Yoshiki Sasai of the RIKEN Center for Developmental Biology in Japan and his colleagues have developed a novel cell-culture method in which embryonic stem cells are grown in suspension instead of on a flat surface. ES cells grown under these conditions can organize themselves into complex 3-D structures when they are treated with the appropriate combination of growth factors. Last year, Sasai's team reported that mouse ES cells cultured in this way recapitulate developmental mechanisms and self-organize into a cupped, layered structure that resembles the embryonic eye and contains all the cell types found in the mature retina, including photoreceptor cells. More

Human on Human Detection Kits

GBI Labs’s Klear Human Polymer Detection kits can detect human primary antibody on human tissue with no background. It is a biotin-free system. Special blocking buffer and human antibody enhancer are used to provide excellent sensitivity and high specificity. MORE


Targeting protein could prevent spread of cancer cells
HealthCanal.com    Share    Share on FacebookTwitterShare on LinkedinE-mail article
Researchers at King's College London have uncovered a protein required by cancer cells to spread to other parts of the body, highlighting it as a potential target for future treatments to prevent secondary cancers. Funded by Cancer Research UK and published in the Journal of Cell Biology, the study looked at how cancer cells form new tumors in other parts of the body. Most cancer deaths are due to cancer metastasis, which develops most commonly in the lungs, bones or liver, yet there are very few treatments designed to prevent this from happening. More

The cell clock: Cellular formation for the next phase of life
Outcome Magazine    Share    Share on FacebookTwitterShare on LinkedinE-mail article
A new way to visualize single-cell activity in living zebrafish embryos has allowed scientists to clarify how cells line up in the right place at the right time to receive signals about the next phase of their life. Scientists developed the imaging tool in single-living cells by fusing a protein defining the cells' cyclical behavior to a yellow fluorescent protein that allows for visualization. More



New type of bacterial protection found within cells
PhysOrg    Share    Share on FacebookTwitterShare on LinkedinE-mail article
University of California-Irvine biologists have discovered that fats within cells store a class of proteins with potent antibacterial activity, revealing a previously unknown type of immune system response that targets and kills bacterial infections. Steven Gross, UCI professor of developmental and cell biology, and colleagues identified this novel intercellular role of histone proteins in fruit flies, and it could herald a new approach to fighting bacterial growth within cells. More


 NSH News


2013 NSH teleconference/webinar series
NSH    Share    Share on FacebookTwitterShare on LinkedinE-mail article
NSH teleconferences (now available as webinars) are a great, inexpensive way to provide continuing education to a large number of employees. The cost for each session is the same regardless of the number of attendees. The one-hour session is usually held the fourth Wednesday of the month, beginning at 1 p.m. EST. Occasionally, due to holidays, it may be the third Wednesday of the month. More


DIGITAL HOLOGRAPHY FOR CELL STUDY

NanoAndMore USA provides DHMs from Lyncée tec and Resolution Optics. They sense the change in the liquid content of cells and image in 3D.
MORE
Sensitive and specific 2-plex RNA-ISH assay

Affymetrix’ QuantiGene® ViewRNA Assays enable single-copy RNA sensitivity with exceptional specificity in FFPE tissue sections. From sequence to assay in 1 week. View recent publications.



 In the News


Jellyfish-inspired device could enable better patient monitoring
R&D Magazine    Share    Share on FacebookTwitterShare on LinkedinE-mail article
Tumor cells circulating in a patient's bloodstream can yield a great deal of information on how a tumor is responding to treatment and what drugs might be more effective against it. But first, these rare cells have to be captured and isolated from the many other cells found in a blood sample. Many scientists are now working on microfluidic devices that can isolate circulating tumor cells, but most of these have two major limitations: It takes too long to process a sufficient amount of blood, and there is no good way to extract cancer cells for analysis after their capture. More



Pancreas stem cell discovery may lead to new diabetes treatments
Medical Xpress    Share    Share on FacebookTwitterShare on LinkedinE-mail article
Stem cells in the adult pancreas have been identified that can be turned into insulin producing cells, a finding that means people with type 1 diabetes might one day be able to regenerate their own insulin-producing cells. The discovery was made by scientists from the Walter and Eliza Hall Institute and provides further evidence that stem cells don't only occur in the embryo. The ability to produce the hormone insulin is crucial for controlling blood sugar (glucose) levels. More


New SOX-11 (MRQ-58) for MCL!
SOX-11 expression is specific for the identification of cyclin D1 negative mantle cell lymphoma. SOX-11 is useful due to its high expression in cyclin D1 positive and negative MCL. Many B-cell lymphomas can mimic MCL; therefore, it’s important to have additional antibodies to detect cyclin D1 negative MCL. Learn More.
DispoCut™ Disposable Dissecting Boards

Lab Storage Systems is proud to offer the DispoCut™ disposable dissecting board. This dissecting board is strong enough to reuse, yet inexpensive enough to throw away. Conveniently printed on both sides in inches and metric measurements. Available in 3 sizes. MORE
StatClick™ Specimen Transport Vials
We’ve added a click and removed the leak. Turn the lid until it clicks. Ship with confidence that your samples and your reputation will stay perfectly preserved. To learn more, please visit us at: www.statlab.com/statclick or contact us at 800-442-3573.


Human models could be way forward for assessing analgesic efficacy
The Medical News    Share    Share on FacebookTwitterShare on LinkedinE-mail article
Researchers say that human experimental pain models could be used to assess the clinical efficacy of analgesics in phase one clinical studies. Bruno Oertel and Jörn Lötsch, both from Goethe University in Frankfurt-Am-Main, Germany, explained in a press statement that finding novel analgesics is difficult as pain cannot be measured directly in animal models and human trials. More



Injectable sponge delivers drugs, cells and structure
MIT News Office via R&D Magazine    Share    Share on FacebookTwitterShare on LinkedinE-mail article
Bioengineers at Harvard University have developed a gel-based sponge that can be molded to any shape, loaded with drugs or stem cells, compressed to a fraction of its size, and delivered via injection. Once inside the body, it pops back to its original shape and gradually releases its cargo, before safely degrading. More


Digital Pathology Tools for Biomarker Research
PerkinElmer offers a range of solutions including streamlined TMA & whole slide scanners, patented multispectral imaging and analysis and automated quantitation of biomarkers in tissue. www.perkinelmer.com/tissueimaging
Earn CE with CAP/NSH HistoQIP
Join more than 1,000 laboratories using the CAP’s HistoQIP (HQIP) to make a good laboratory even better. Submit slides to assess your histologists’ technique.


Detection, analysis of 'cell dust' may allow diagnosis, monitoring of brain cancer
Mass General via Bioscience Technology    Share    Share on FacebookTwitterShare on LinkedinE-mail article
A novel miniature diagnostic platform using nuclear magnetic resonance technology is capable of detecting minuscule cell particles known as microvesicles in a drop of blood. Microvesicles shed by cancer cells are even more numerous than those released by normal cells, so detecting them could prove a simple means for diagnosing cancer. More

Biomarker works for asbestos-linked cancer
MedPage Today    Share    Share on FacebookTwitterShare on LinkedinE-mail article
Glycoprotein fibulin-3 can be used to identify patients with pleural mesothelioma and may be a useful biomarker for the asbestos-related illness, researchers reported. Plasma levels of the protein were higher in people with the disease than they were in people exposed to asbestos but who did not have mesothelioma, according to Dr. Harvey Pass of New York University Langone Medical Center, and colleagues. More

Avantik Pre-Filled Formalin Containers

These convenient pre-filled formalin containers are designed with a proprietary patented closure… 100% Leak-proof…guaranteed! 95 kPa compliant. Each container is half filled with 10% neutral buffered formalin. Available in the following sizes: 20, 40, 60, 90, 120mL. Call for your free sample. Volume discounts available.


8 often-overlooked tips for membrane protein crystallization
Genetic Engineering & Biotechnology News    Share    Share on FacebookTwitterShare on LinkedinE-mail article
Protein crystals are necessary prerequisites for their detailed structural study by X-ray crystallography. Growing membrane protein crystals is typically a laborious trial and error-type search process that requires patience and willingness to explore alternatives outside of standard protocols. Here are eight often-overlooked tips to consider when embarking on a membrane protein crystallization project. More


Get your histology CE from MediaLab

Explore our online interactive histology courses, and discover the latest secrets for creating flawless IHC, FISH, special, and routine stains. Complete your annual safety and compliance training hassle free. Document training and get P.A.C.E credits with the included Learning Management System. Get it all with our unlimited annual subscription, available for both individuals and institutions.
Spring Bioscience - BRAF V600E

Spring Bioscience is leading the research industry by pioneering novel, next generation antibodies that can differentiate mutant and normal protein, enabling pathologists to see relevant mutations within their cellular context. Having already released Exon19 and EGFR L858R for exclusive use by Ventana Medical Systems, Spring Bioscience has launched BRAF V600E.
Click here to find out more.
EndNote X6
EndNote® enables you to move seamlessly through your research process with flexible tools for searching, organizing and sharing your research, creating your bibliography and writing your paper. New in X6: Access your research from anywhere and manage your EndNote library from multiple computers with the new EndNoteSync.
 

Under the Microscope
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